Zhangsuo Liu

Methyltransferase-like 3 mediates m6A modification of heme oxygenase 1 mRNA to induce ferroptosis of renal tubular epithelial cells in acute kidney injury

Linxiao Lv, Mingyang Hu, Jiacheng Li, Runzhi Guo et autres

Acute kidney injury (AKI) involves a series of syndromes characterized by a rapid increase in creatinine levels. Ferroptosis, as an iron-dependent mode of programmed cell death, reportedly participates in the pathogenesis of AKI. Methyltransferase-like 3 (METTL3)-mediated N6-methyladenosine (m6A) modification has been recently …

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Prognosis of IgA nephropathy patient with proteinuria remission by supportive therapy: cohort from screening failed Chinese patients in TESTING study

Yingman Guo, Sufang Shi, Jinghong Zhao, Caili Wang et autres

Background During the run-in phase of the TESTING study, approximately half of patients with IgA nephropathy (IgAN) were excluded due to proteinuria below 1 g/24 h after intensive supportive therapy. The long-term prognosis of these patients needs further investigation.Methods 112 screening failed …

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Emerging Role of Ferroptosis in Diabetic Kidney Disease: Molecular Mechanisms and Therapeutic Opportunities

Hui Wang, Dongwei Liu, Bin Zheng, Yang Yang et autres

Diabetic kidney disease (DKD) is one of the most common and severe microvascular complications of diabetes mellitus (DM), and has become the leading cause of end-stage renal disease (ESRD) worldwide. Although the exact pathogenic mechanism of DKD is still unclear, programmed cell …

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Effect of Tacrolimus vs Intravenous Cyclophosphamide on Complete or Partial Response in Patients With Lupus Nephritis

Zhaohui Zheng, Haitao Zhang, Xiaomei Peng, Chun Zhang et autres

Importance: Lupus nephritis (LN) is typically treated with intravenous cyclophosphamide (IVCY), which is associated with serious adverse effects. Tacrolimus may be an alternative for initial treatment of LN; however, large-scale, randomized clinical studies of tacrolimus are lacking. Objective: To assess efficacy and …

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Lysine Acetylation in the Proteome of Renal Tubular Epithelial Cells in Diabetic Nephropathy

Jiayi Wan, Mingyang Hu, Ziming Jiang, Dongwei Liu et autres

Diabetic nephropathy is considered one of the most common microvascular complications of diabetes and the pathophysiology involves multiple factors. Progressive diabetic nephropathy is believed to be related to the structure and function of the tubular epithelial cells in the kidney. However, the …

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Diabetes Mellitus as a Risk Factor for Progression from Acute Kidney Injury to Acute Kidney Disease: A Specific Prediction Model

Huanhuan Zhao, Lulu Liang, Shaokang Pan, Zhenjie Liu et autres

PURPOSE: Acute kidney injury is very common in hospitalized patients and carries a significant risk of mortality. Although timely intervention may improve patient prognosis, studies on the development of acute kidney disease in patients with acute kidney injury remain scarce. Thus, we …

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Multitarget Therapy for Maintenance Treatment of Lupus Nephritis

Haitao Zhang, Zhengzhao Liu, Minlin Zhou, Zhangsuo Liu et autres

Our previous studies showed that multitarget therapy is superior in efficacy to intravenous cyclophosphamide as an induction treatment for lupus nephritis in Asian populations. We conducted an open label, multicenter study for 18 months as an extension of the prior induction therapy …

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Multitarget Therapy for Induction Treatment of Lupus Nephritis

Zhihong Liu, Haitao Zhang, Zhangsuo Liu, Xing Changying et autres

BACKGROUND: Treatment of lupus nephritis (LN) remains challenging. OBJECTIVE: To assess the efficacy and safety of a multitarget therapy consisting of tacrolimus, mycophenolate mofetil, and steroid compared with intravenous cyclophosphamide and steroid as induction therapy for LN. DESIGN: 24-week randomized, open-label, multicenter …

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Management of thallium poisoning in patients with delayed hospital admission

Tong-Wen Sun, Qingyang Xu, Xiaojuan Zhang, Qiong Wu et autres

OBJECTIVE: To describe the clinical features and management of thallium poisoning in patients with delayed hospital admission. METHODS: Fourteen patients (median age 36 years) were admitted 9-19 days after ingesting food poisoned with thallium. Clinical and laboratory data, including blood and urine …

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Effects of rosiglitazone on cyclosporine A-related renal toxicity in rats

Dong Ji, Zhangsuo Liu, Genyang Cheng, Songxia Quan

目的:观察罗格列酮(RGZ)对环孢素A(CsA)所致肾组织炎细胞浸润及肾间质纤维化的作用,探讨RGZ对CsA肾病(CCN)的保护作用.方法:将28只健康雄性SD大鼠随机分成:①对照组(n=6),LSD;②RGZ组(n=6),LSD+RGZ[5 mg/(kg·d)];③CsA组(n=8),LSD+CsA[15 mg/(kg·d)],④RGZ+CsA组(n=8),LSD+CsA[15 mg/(kg·d)]+RGZ(5 mg/(kg·d)).在实验开始后的2 wk及5 wk处死大鼠,分别用免疫组化方法检测CD68和ColⅣ,RT-PCR方法检测MMP-9和TIMP-1的表达量;HE,Masson染色观察肾脏病理改变.结果:与对照组相比,CsA组及RGZ+CsA组CD68,ColⅣ,MMP-9,TIMP-1的表达均增高,肾小管间质单个核细胞浸润数及肾间质纤维化程度显著增加,且CsA组显著高于RGZ+CsA组.RGZ组无明显变化.结论:RGZ可显著降低CsA对肾脏的毒性作用,其机制部分是通过降低CCN大鼠CD68,ColⅣ,MMP-9,TIMP-1的表达,从而改善肾间质纤维化.