Zhaohui Zheng

Evaluation of combined anti-anaemia and DMARD therapy for rheumatoid arthritis-related anaemia: a retrospective cohort study

Xinyi Wang, Guangzhi Xiao, Yanwen Liu, Youqun Zhang et autres

OBJECTIVES: Anaemia is a common comorbidity of rheumatoid arthritis (RA). Disease-modifying anti-rheumatic drugs (DMARDs) are currently the mainstay for relieving anaemia by suppressing inflammation; however, some patients fail to achieve satisfactory responses and thus require combined anti-anaemic therapy. This study aimed to …

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Characteristics and clinical significance of aortic ulcer signs on computed tomography angiography in patients with Takayasu's arteritis

Yi-Xiang Wang, Li Shen, H X Liu, Wenjuan Wang et autres

OBJECTIVES: To explore the clinical and disease characteristics associated with aortic ulcers signs on computed tomography angiography (CTA) in patients with Takayasu's arteritis (TAK). METHODS: We retrospectively analysed CTA scans from consecutive TAK patients at Xijing Hospital between 2021 and 2025. We …

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Combination therapy improves survival prognosis in anti-MDA5-antibody-positive dermatomyositis patients: a single-center retrospective study

Congcong Gao, Gaohui Wei, Zesong Li, Chunyi Zhang et autres

Background: Anti-melanoma differentiation-associated gene 5 antibody-positive dermatomyositis (MDA5+DM) is associated with poor prognosis and high mortality, presenting significant challenges for treating this intractable disease. This study aimed to compare the efficacy and safety of calcineurin inhibitor monotherapy (CNI) versus combination therapy [CNI …

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Effect of cross-linker structure on thermal and mechanical properties of poly(methyl methacrylate) networks

Yuting Wu, Jiji Tan, Shuhan Chen, Zhaohui Zheng et autres

To investigate the impact of cross-linker chemical structure on the thermal and mechanical properties of PMMA, this study designed and synthesized three alkynyl-terminated cross-linkers with distinct structural features: rigid and symmetrical tetra-alkyne pentaerythritol (TPOM), flexible di-alkyne dodecanediol (BD), and tetra-alkyne dodecyldiamine (TDM) …

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[Clear cell renal cell carcinoma complicated with Langerhans cell histiocytosis: report of a case].

Zhaohui Zheng, Fang Peng, Weixian Wang, X J Wang et autres

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Meplazumab, a CD147 antibody, for severe COVID-19: a double-blind, randomized, placebo-controlled, phase 3 clinical trial

Huijie Bian, Chen Liang, Zheng Zhang, Aidong Wen et autres

Meplazumab, a humanized CD147 antibody, showed favorable safety and clinical benefits in phase 1 and phase 2/3 seamless clinical studies. Further evaluation of its therapeutic efficacy in patients with severe COVID-19 is needed. In this phase 3 add-on study, we randomized patients …

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The Prospective Registry of MyositIS (PROMIS): Temporal Shifts in Causes of Death Among Patients with Idiopathic Inflammatory Myopathies

Liying Peng, Shangyi Jin, Chanyuan Wu, Xinwang Duan et autres

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Performance of the Expanded Cardiovascular Risk Prediction Score for Rheumatoid Arthritis (ERS-RA) in a Nationwide Multicenter Chinese Cohort

Xingbei Dong, Hong Li, Misti L. Paudel, Jiangmei Liu et autres

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Chinese guidelines for the diagnosis and treatment of rheumatoid arthritis: 2024 update

Xinping Tian, Qian Wang, Nan Jiang, Yan Zhao et autres

Rheumatoid arthritis (RA) is an autoimmune disease with destructive arthritis as its main clinical manifestation, which is a major cause of disability. It is very important to formulate and update a guideline for the diagnosis and treatment of RA that adhere to …

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Pneumocystis jirovecii pneumonia increases the 3-months mortality of anti-MDA5-antibody-positive dermatomyositis patients

Congcong Gao, Gaohui Wei, Chunyi Zhang, Chenqiong Wang et autres

Background: Anti-melanoma differentiation-associated gene 5 antibody-positive dermatomyositis (anti-MDA5+DM) patients are associated with considerable mortality, and opportunistic infections including Pneumocystis jirovecii pneumonia (PJP)is the main cause. This study was to identify clinical characteristics, risk factors, and prognostic factors of PJP diagnosed by bronchoalveolar …

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Emodin combined with 5‐aminolevulinic acid photodynamic therapy inhibits condyloma acuminate angiogenesis by targeting SerRS

Hongyan Lu, Zhangsong Peng, Yingrui Luo, Zhaohui Zheng et autres

Human papillomavirus (HPV) infection can cause condyloma acuminatum (CA), which is characterized by a high incidence and a propensity for recurrence after treatment. Angiogenesis plays an important role in the occurrence and development of CA. Seryl-tRNA synthetase (SerRS) is a newly identified, …

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Blocking the ATR‐SerRS‐VEGFA pathway targets angiogenesis for UV‐induced cutaneous squamous cell carcinoma

Hongyan Lu, Zhangsong Peng, Zhaohui Zheng, Changxing Li et autres

Cutaneous squamous cell carcinoma (cSCC) is the second most prevalent form of skin cancer, with an escalating incidence rate and a notable potential (up to 5%) for metastasis. Ultraviolet radiation (UVA and UVB) exposure is the primary risk factor for cSCC carcinogenesis, …

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