Shaokang Pan

FTO Modulates m 6 A RNA Methylation of STC1 to Regulate Inflammation and Oxidative Stress in Diabetic Nephropathy

Shaokang Pan, Duopin Li, Fengyu Cao, Sijie Zhou et autres

ABSTRACT Diabetic nephropathy (DN) is a major cause of chronic kidney disease, driven by hyperglycemia‐induced kidney damage. Recently research has highlighted the role of N6‐methyladenosine (m 6 A) RNA methylation in the progression of DN. The role of the fat mass and …

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The Gut–Kidney Dialogue: Unraveling the Microbial Symphony in Renal Fibrosis

Zi‐Hui Mao, Y. Liu, Shaokang Pan, Qing Zhang et autres

Renal fibrosis is a maladaptive pathological endpoint common to the diverse etiologies of chronic kidney disease (CKD), resulting in irreversible nephron loss and functional decline. Emerging evidence has highlighted the potential role of the gut microbiota in renal fibrosis through bidirectional interactions …

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Targeting Mitochondrial Dysfunction by Natural Products for the Treatment of Diabetic Kidney Disease

Jin‐Ling Huo, Peipei Li, Qi Feng, Wenyu Fu et autres

Diabetic kidney disease (DKD) is one of the most common complications of diabetes and is the primary cause of end-stage renal disease (ESRD). However, due to its complex pathological mechanism, there is a lack of effective targeted drugs for DKD. Natural products, …

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Mitochondria‐Associated Endoplasmic Reticulum Membranes in Human Health and Diseases

Yong Liu, Zi‐Hui Mao, Junwen Huang, Hui Wang et autres

As fundamental units of life activities, cells exhibit a high degree of structural refinement and functional specialization, forming the cornerstone of life complexity. Compartmentalization within cells is pivotal for maintaining the orderly progression of intracellular biochemical processes. Cellular compartments constitute the enclosed …

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CNPY2 Aggravates Renal Tubular Cell Ferroptosis in Diabetic Nephropathy by Regulating PERK/ATF4/CHAC1 Pathway and MAM Integrity

Jingfang Chen, Dongwei Liu, Lei Lei, Ting Liu et autres

Ferroptosis is emerging as a novel mechanism for understanding renal tubular injury in diabetic nephropathy (DN). The mitochondria-associated endoplasmic reticulum membrane (MAM) plays a crucial role in the regulation of numerous cellular processes, including mitochondrial dysfunction and endoplasmic reticulum (ER) stress (ERS). …

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[The mechanism of β-hydroxybutyrylation in G6PDX regulated by β-hydroxybutyric acid on alleviating podocyte injury induced by high glucose].

L.F. Lyu, Mingyang Hu, Yibo Lei, Shaokang Pan et autres

β-HB mediated β-hydroxybutyrylation of G6PDX can alleviate podocyte injury induced by high glucose.

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[Progress and prospects of finerenone in the treatment of type 2 diabetes mellitus related chronic kidney disease].

X P Zhang, Shaokang Pan, Kun Chen, D W Liu et autres

The number of patients with type 2 diabetes mellitus (T2DM)-related chronic kidney disease (CKD) is substantial, and the disease burden is severe. Despite current treatment options, even with standard therapy, patients still face a high risk of kidney disease progression and cardiovascular …

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The PM2.5 component, benzo[b]fluoranthene, may contribute to the pathogenesis of membranous nephropathy by activating phosphoinositide 3-kinase/protein kinase B pathway and causing podocyte pyroptosis

Dongqi Li, Shi Yan, Qi Feng, Fei Tian et autres

Membranous nephropathy (MN) is the main type of adult nephrotic syndrome, and its prevalence is increasing annually. An increasing number of studies have suggested that the pathogenesis of MN is related to 2.5-μm particulate matter (PM2.5), but the underlying mechanism has not …

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Blockade of neddylation through targeted inhibition of DCN1 alleviates renal fibrosis

Jin‐Ling Huo, Wenyu Fu, Feng Qi, Shaokang Pan et autres

Neddylation is a process of attaching neuronal precursor cell-expressed developmentally down-regulated protein 8 (NEDD8) to substrates for the protein function modulation via enzymatic cascades involving NEDD8-activating enzyme (E1), NEDD8-conjugating enzyme (E2), and NEDD8 ligase (E3). Defective in cullin neddylation 1 (DCN1) serves …

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Emerging role of PANoptosis in kidney diseases: molecular mechanisms and therapeutic opportunities

Yiping Hou, Qi Feng, Cien Wei, Fengyu Cao et autres

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Proteomics uncovers ICAM2 (CD102) as a novel serum biomarker of proliferative lupus nephritis

Zhengyong Li, Yifang Sun, Yixue Wang, Fengxun Liu et autres

OBJECTIVES: This study aimed to identify novel, non-invasive biomarkers for lupus nephritis (LN) through serum proteomics. METHODS: Serum proteins were detected in patients with LN and healthy control (HC) groups through liquid chromatography-tandem mass spectrometry. The key networks associated with LN were …

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Epigenetic Regulation of Ferroptosis in Chronic Kidney Disease: Mechanisms and Implications

Zi‐Hui Mao, Yong Liu, Qing Zhang, Shaokang Pan et autres

Chronic kidney disease (CKD) is a prevalent and progressive condition that leads to renal structural abnormalities and a gradual decline in kidney function. CKD has various etiologies, including diabetes, hypertension, and glomerulonephritis, and is associated with significant morbidity, mortality, and economic burden. …

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