Rebecca Carter

Navitoclax acts synergistically with irradiation to induce apoptosis in preclinical models of H3K27M-altered diffuse midline glioma

Ashley Vardon, Scott Haston, Hiba Hamdi, Grace Cooksley et autres

Diffuse midline gliomas (DMGs) with histone H3K27M mutations represent a devastating paediatric brain cancer characterised by abysmal prognosis and limited treatment options. The only approved treatment is radiotherapy (RT), but most of the tumours relapse with fatal consequences. The effects of RT …

gb, fr, us, es (code pays fourni par la source)

Targeted inhibition of Bcl-xL following radiation reduces tumourigenesis in preclinical models of H3K27M-altered diffuse midline glioma

Ashley Vardon, Scott Haston, Romain Guiho, Diana Carvahlo et autres

Abstract Background Diffuse midline gliomas (DMGs) with histone H3K27M mutations represent a devastating paediatric brain cancer characterized by abysmal prognosis and limited treatment options. The only approved treatment is radiotherapy (RT), but most of the tumours relapse with fatal consequences. In this …

gb, us, es (code pays fourni par la source)

Verbal Autopsy to Assess Postdischarge Mortality in Children With Suspected Sepsis in Uganda

Martina Knappett, Anneka M. Hooft, Muhammad Bilal Maqsood, Pascal M. Lavoie et autres

BACKGROUND: Reducing child mortality in low-income countries is constrained by a lack of vital statistics. In the absence of such data, verbal autopsies provide an acceptable method to determining attributable causes of death. The objective was to assess potential causes of pediatric …

ca, gb, us, Kenya, Ouganda, Afrique du Sud (code pays fourni par la source)

Congenital CMV associated with diaphragm dysfunction: a rare cause of tachypnoea

Rebecca Carter, Maayan Yakir, Julie Ryu, Katherine C. B. Weiss

A late preterm infant with intrauterine growth restriction developed respiratory distress, tachypnoea and hypoxia after birth, requiring supplemental oxygen. Chest radiographs demonstrated persistent elevation of the right hemidiaphragm. Chest ultrasound initially demonstrated symmetrical bilateral diaphragm motion, but subsequent ultrasounds showed asymmetrical excursion …

us (code pays fourni par la source)

DIPG-46. Radiation induced senescence in diffuse intrinsic pontine glioma cells reveals selective vulnerability to Bcl-XL inhibition

Ashley Vardon, Romain Guiho, Diana M. Carvalho, Jessica K.R. Boult et autres

Abstract Diffuse intrinsic pontine glioma remains a devastating condition with a dismal five year survival rate less than 5%. New approaches for treating this aggressive disease are critical to driving progress. Conventional radiotherapy remains the cornerstone of treatment, with no chemotherapeutic agent …

gb, us (code pays fourni par la source)

Severe thrombocytopenia and intracranial hemorrhage in a newborn with Noonan syndrome and neonatal alloimmune thrombocytopenia

Rebecca Carter, Anna‐Kaisa Niemi

Noonan syndrome (NS) is a genetic disorder with distinctive physical features and often multiple organ involvement. Bleeding disorders are reported in over half of patients with NS, including thrombocytopenia and platelet dysfunction. Neonatal alloimmune thrombocytopenia (NAIT) is an alloantigenic thrombocytopenia that can …

us (code pays fourni par la source)

Peer Review Report For: Facility conditions, obstetric and neonatal care practices, and availability of emergency obstetric and neonatal care in 72 rural health facilities in the Democratic Republic of the Congo: A cross-sectional study [version 2; peer review: 2 approved]

Rebecca Carter, Xu Xiong, Paul-Samson Lusamba-Dikassa, Elvis C. Kuburhanwa et autres

Background: Current facility conditions, obstetric and neonatal care practices, and availability of emergency obstetric and neonatal care (EmONC) were assessed in the Kwango and Kwilu provinces of the Democratic Republic of the Congo (DRC). Methods: This is an analysis of the baseline …

us, République démocratique du Congo, Tunisie (code pays fourni par la source)

Peer Review Report For: Facility conditions, obstetric and neonatal care practices, and availability of emergency obstetric and neonatal care in 72 rural health facilities in the Democratic Republic of the Congo: A cross-sectional study [version 1; peer review: 1 approved, 1 approved with reservations]

Rebecca Carter, Xu Xiong, Paul-Samson Lusamba-Dikassa, Elvis C. Kuburhanwa et autres

Background: Current facility conditions, obstetric and neonatal care practices, and availability of emergency obstetric and neonatal care (EmONC) were assessed in the Kwango and Kwilu provinces of the Democratic Republic of the Congo (DRC). Methods: This is an analysis of the baseline …

us, République démocratique du Congo, Tunisie (code pays fourni par la source)

Peer Review Report For: Facility conditions, obstetric and neonatal care practices, and availability of emergency obstetric and neonatal care in 72 rural health facilities in the Democratic Republic of the Congo: A cross-sectional study [version 1; peer review: 1 approved, 1 approved with reservations]

Rebecca Carter, Xu Xiong, Paul-Samson Lusamba-Dikassa, Elvis C. Kuburhanwa et autres

Background: Current facility conditions, obstetric and neonatal care practices, and availability of emergency obstetric and neonatal care (EmONC) were assessed in the Kwango and Kwilu provinces of the Democratic Republic of the Congo (DRC). Methods: This is an analysis of the baseline …

us, République démocratique du Congo, Tunisie (code pays fourni par la source)

Response to: Milosavljevic et al. “Two cases of RIT1 associated Noonan syndrome: Further delineation of the clinical phenotype and review of the literature”

Blair Stevens, Anthony M. Johnson, Thomas F. Rowe, Rebecca Carter et autres

us (code pays fourni par la source)

Cellular Proliferation Markers in Lamellar Tissue and Skin Measured by Indirect Immunofluorescence

Rebecca Carter, Susan O. Megee, Julie B. Engiles, Makoto Senoo et autres

us (code pays fourni par la source)

A Family Study of Aortic Stenosis

H E Zoethout, Rebecca Carter, C. O. Carter

The association of aortic stenosis with von Recklinghausen's multiple neurofibromatosis is noted for the first time in this series (R.E.B.C.

gb (code pays fourni par la source)