Mazlina Ismail

ERG Orchestrates a Dedifferentiation–Senescence–Inflammation Triad in Prostate Cancer

Francesca Lorenzin, Giulia Fracassi, Federico Vannuccini, Mazlina Ismail et autres

ERG fusions occur in about 50% of prostate cancers (PCa) and represent early somatic events that co-initiate tumorigenesis. Yet, the molecular programs unleashed by ERG at disease onset remain elusive. Here, the inducible, temporally controlled expression of ERG enabled the accurate mapping …

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innate2adaptive/decombinator: v5.2.0

Matthew V. Cowley, James Heather, Katherine Best, Mazlina Ismail et autres

decombinator is a fast and efficient tool for the analysis of T-cell receptor (TCR) repertoire sequences produced by deep sequencing. It accepts TCR repertoire sequencing (TCRseq) FASTQ data and returns AIRR compliant files detailing TCR V(D)J recombination and counts. TCRseq offers a …

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Abstract LB246: Neoadjuvant androgen signaling inhibition promotes the emergence of mixed basal/club-like cancer identity cells in prostate cancer tumors

Antti Kiviaho, Thomas Cecchetto, Sini K. Eerola, Mazlina Ismail et autres

Abstract Background: Therapies targeting androgen signaling are a cornerstone of high-risk prostate cancer treatment. Recently published evidence from the ARNEO trial (NCT03080116) shows that treatment intensification with androgen receptor signaling inhibitors (ARSIs) added to standard androgen deprivation therapy (ADT) significantly reduces residual …

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Abstract B079: Persist: a molecular signature for prostate cancer patients with preexisting treatment-persistent cells associated with aggressive disease

Francesco Ballesio, Sinja Taavitsainen, Mohammed Alshalalfa, Antti Kiviaho et autres

Abstract Background Prostate cancer is a heterogeneous disease comprising diverse cell types within the tumor microenvironment that support cancer cell survival. Using single cell and spatial transcriptomics, we previously identified subpopulations of treatment-persistent cancer cells exhibiting regenerative properties and a distinct molecular …

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Role of educators as mentors, guides, and learning designers from academicians’ perspectives in Malaysia

Mazlina Ismail, Nur Adilah Saud, Chinniah Muruga

Driven by globalisation, technological advancements, and the transition toward a knowledge-based economy, the landscape of higher education in Malaysia has undergone a significant paradigm shift. This paper explores the evolving responsibilities of modern educators, moving away from traditional, passive knowledge transmission toward …

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The importance of project-based learning in understanding management theories through real life applications: UiTM Johor case study

Muruga Chinniah, Nur Adilah Saud, Mazlina Ismail

Accelerating environmental degradation caused by mismanaged solid waste highlights a critical societal need for increased recycling awareness and improved waste disposal practices. To address this issue, UiTM Johor Branch, Segamat Campus organized the community-driven program “Think Before You Throw, Let’s Recycle”. This …

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The evolution of service marketing

Nur Adilah Saud, Mazlina Ismail, Muruga Chinniah

This article traces and analyzes the historical evolution of service marketing as a distinct academic discipline and management practice, arising from the global economic shift towards service-dominated markets. Initially overshadowed by goods-centric marketing frameworks prior to the 1970s, the unique and complex …

Plastic consumption in the digital era: a bibliometric analysis based on author and index keywords

Che Faridah Che Mahmood, Nor Zubaidah Nor Albashri, Mazlina Ismail, Nur Adilah Saud et autres

Although plastic is widely used for its affordability and durability, excessive consumption and improper disposal pose serious environmental risks. Digital technologies and ICT offer potential solutions, but bibliometric studies examining plastic consumption through digital innovation remain scarce. Subsequently, this study employs bibliometric …

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Tumor transcriptome-wide expression classifiers predict treatment sensitivity in advanced prostate cancers

Emily Grist, Peter Dutey‐Magni, Marina Parry, Larissa Sena Teixeira Mendes et autres

Advanced prostate cancers respond to hormone therapy but outcomes vary and no predictive tests exist for informed treatment selection. To identify novel biomarker-treatment pairings, we examined associations between biological pathways and 14-year survival outcomes of patients randomized in practice-changing phase 3 trials …

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Transcriptome classification of PTEN inactivation to predict survival benefit from docetaxel at start of androgen deprivation therapy (ADT) for metastatic prostate cancer (PC): An ancillary study of the STAMPEDE trials.

Emily Grist, Peter Dutey‐Magni, Marina Parry, Larissa Sena Teixeira Mendes et autres

5003 Background: Docetaxel (Doce) is effective for metastatic (M1) PC but its effect is varied. Combining Doce and hormone therapy can improve overall survival (OS) but is not appropriate for all. We previously reported the mRNA Decipher test predicts benefit from Doce. …

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Abstract 5314: Prostate club-like cells resist treatment and carry prognostic value in lung and pancreatic adenocarcinoma

Antti Kiviaho, Sini K. Eerola, Heini M. L. Kallio, Miina Hoikka et autres

Abstract Introduction: The prostate cancer tumor microenvironment (TME) contains various cell type identities. We recently described club-like epithelial cells as a constitutive part of the TME present in tissue regions with increased myeloid-derived suppressor cell infiltration. The origin, exact function, and identity …

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Comparative transcriptomics reveals a mixed basal, club, and hillock epithelial cell identity in castration-resistant prostate cancer

Samuel P. Pitzen, Amber N. Rudenick, Yinjie Qiu, Weijie Zhang et autres

Inhibiting the androgen receptor (AR) is effective for treatment of advanced prostate cancers because of their AR-dependent luminal epithelial cell identity. Tumors progress during therapy to castration-resistant prostate cancer (CRPC) by restoring AR signaling and maintaining luminal identity or by converting through …

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