Shinya Tanaka

Age-associated erosion of organ-specific endothelial programs compromises tissue function and resilience

Haruko Watanabe‐Takano, Tomohiro Ishii, Tomohisa Hayakawa, Hitoshi Iuchi et autres

Summary Endothelial cells (ECs) express organ-specific gene programs supporting tissue homeostasis and resilience. However, the mechanisms by which aging reshapes these organ-specific endothelial programs and how the resulting changes affect tissue homeostasis, resilience, and disease susceptibility remain largely unknown. Herein, we performed …

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Multifocal Rosette-forming Glioneuronal Tumor-like Low-Grade Glioneuronal Tumor with Dysembryoplastic Neuroepithelial Tumor Features Associated with Drug-Resistant Epilepsy: A Case Report and Literature Review

Yuuki Ishida, Koki Ise, Kenichi Sato, Taku Asanome et autres

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Humoral responses are enhanced by facilitating B cell viability by Fcrl5 overexpression in B cells

Chisato Ono, Yuta Kochi, Yoshihiro Baba, Shinya Tanaka

B cell initial activity is regulated through a balance of activation and suppression mediated by regulatory molecules expressed in B cells; however, the molecular mechanisms underlying this process remain incompletely understood. In this study, we investigated the function of the Fc receptor-like …

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Upregulated Fcrl5 disrupts B cell anergy and causes autoimmune disease

Chisato Ono, Shinya Tanaka, Keiko Myouzen, Takeshi Iwasaki et autres

B cell anergy plays a critical role in maintaining self-tolerance by inhibiting autoreactive B cell activation to prevent autoimmune diseases. Here, we demonstrated that Fc receptor-like 5 (Fcrl5) upregulation contributes to autoimmune disease pathogenesis by disrupting B cell anergy. Fcrl5-a gene whose …

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Upregulated Fcrl5 disrupts B cell anergy and causes autoimmunity

Chisato Ono, Shinya Tanaka, Keiko Myouzen, Takeshi Iwasaki et autres

Abstract B cell anergy plays a critical role in maintaining self-tolerance by inhibiting autoreactive B cell activation to prevent autoimmune diseases. Here, we demonstrated that Fc receptor-like 5 (Fcrl5) upregulation contributes to autoimmune disease pathogenesis by disrupting B cell anergy. Fcrl5—a gene …

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Data from Adaptor Molecule Crk Is Required for Sustained Phosphorylation of Grb2-Associated Binder 1 and Hepatocyte Growth Factor–Induced Cell Motility of Human Synovial Sarcoma Cell Lines

Takuya Watanabe, Masumi Tsuda, Yoshinori Makino, Shin Ichihara et autres

Abstract Activation of the c-Met receptor tyrosine kinase through its ligand, hepatocyte growth factor (HGF), promotes mitogenic, motogenic, and morphogenic cellular responses. Aberrant HGF/c-Met signaling has been strongly implicated in tumor cell invasion and metastasis. Both HGF and its receptor c-Met have …

Data from Adaptor Molecule Crk Is Required for Sustained Phosphorylation of Grb2-Associated Binder 1 and Hepatocyte Growth Factor–Induced Cell Motility of Human Synovial Sarcoma Cell Lines

Takuya Watanabe, Masumi Tsuda, Yoshinori Makino, Shin Ichihara et autres

Abstract Activation of the c-Met receptor tyrosine kinase through its ligand, hepatocyte growth factor (HGF), promotes mitogenic, motogenic, and morphogenic cellular responses. Aberrant HGF/c-Met signaling has been strongly implicated in tumor cell invasion and metastasis. Both HGF and its receptor c-Met have …

Supplementary Methods, Table 1, Figures 1-2 from Enhancement of TGF-β Signaling Responses by the E3 Ubiquitin Ligase Arkadia Provides Tumor Suppression in Colorectal Cancer

Vikas Sharma, Anna G. Antonacopoulou, Shinya Tanaka, Alexios A. Panoutsopoulos et autres

Supplementary Methods, Table 1, Figures 1-2 from Enhancement of TGF-β Signaling Responses by the E3 Ubiquitin Ligase Arkadia Provides Tumor Suppression in Colorectal Cancer

Quiescent B Cells Acquire Sensitivity to Cell Cycle Arresting Agents by B Cell Receptor Stimulation

Takanatsu Hosokawa, Shinya Tanaka, Takeshi Mori, Yoshihiro Baba et autres

For the treatment of autoimmune diseases, depletion of B cells specific for auto-antigens is important because they will be a source of plasmablasts/plasma cells to produce autoantibodies. However, because some types of B cells like naïve B cells and memory B cells …

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Silencing and activating anergic B cells*

Shinya Tanaka, Wataru Ise, Yoshihiro Baba, Tomohiro Kurosaki

Despite the existence of central tolerance mechanisms, including clonal deletion and receptor editing to eliminate self-reactive B cells, moderately self-reactive cells still survive in the periphery (about 20% of peripheral B cells). These cells normally exist in a functionally silenced state called …

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Publisher Correction: Tet2 and Tet3 in B cells are required to repress CD86 and prevent autoimmunity

Shinya Tanaka, Wataru Ise, Takeshi Inoue, Ayako Ito et autres

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Correction: CCAAT/Enhancer-Binding Protein α Negatively Regulates IFN-γ Expression in T Cells

Shinya Tanaka, Kentaro Tanaka, Fay Magnusson, Yeonseok Chung et autres