Yeonseok Chung

The interplay between lipid metabolism, cancer progression and anti-cancer immunity

Choong‐Hyun Koh, Y. Lee, Il‐Kyu Kim, Yeonseok Chung

The tumour microenvironment (TME) consists of a complex ecosystem of tumour cells, stromal elements, extracellular matrix, fibroblasts and diverse immune-cell populations. Although traditional cancer therapies have primarily focused on eliminating tumour cells, subsequent advances highlighted the importance of modulating immune cells within …

gb, kr (code pays fourni par la source)

Liver Stiffness Directs Intrahepatic Cholesterol Accumulation Through YAP/TAZ in Metabolic Dysfunction‐Associated Steatotic Liver Disease

Na Young Lee, Myeung Gi Choi, Ho Jae Ryu, Young Jin Min et autres

Elevated liver stiffness is closely associated with morbidity and mortality in metabolic dysfunction-associated steatotic liver disease (MASLD). However, the contribution of increased stiffness to impaired liver function is poorly understood. Here, we demonstrate that hepatic cholesterol levels are determined by the stiffness …

kr, Éthiopie (code pays fourni par la source)

‘DieT’ control: how dietary fats make T cells die

Y. Lee, Choong-Hyun Koh, Yeojin Jeon, Yeonseok Chung

Regulation of T Cell Senescence in Health and Diseases

Sewon Mun, S Choi, Jae‐Joong Kim, Jihyun Kim et autres

Aging is accompanied by a progressive decline in immune function, a process termed immunosenescence, which affects both innate and adaptive immune compartments.Among these, the adaptive immune system-and particularly T cells-undergoes the most profound functional and phenotypic alterations, critically impairing host defense against …

kr (code pays fourni par la source)

Structure-activity relationship analysis of 5′-substituted C2-hexynyl-4′-thioadenosine analogs as dual A2A/A3 adenosine receptor agonists with tunable selectivity and anti-inflammatory activity

Seung Wook Kim, Jahyun Bok, Hongseok Choi, Gibae Kim et autres

kr (code pays fourni par la source)

Discovery of natural RORγt inhibitor using machine learning, virtual screening, and in vivo validation

Hojin Yoo, Sang-Jun Han, C.-H. Cho, Birang Jeong et autres

INTRODUCTION: Retinoic acid receptor-related orphan receptor gamma t (RORγt) is a crucial transcription factor regulating Th17 cells, which secrete the cytokine IL-17. RORγt inhibitors are regarded as a therapeutic modality in a wide range of autoimmunity including psoriasis. OBJECTIVES: The objective of …

us, kr, Éthiopie, pr (code pays fourni par la source)

Regulation of Ferroptosis in Cancer and Immune Cells

Naeyoon Jang, Il‐Kyu Kim, Yeonseok Chung, Yun Pyo Kang

Ferroptosis, an iron-dependent form of regulated cell death, is driven by lipid peroxidation and shaped by metabolic and antioxidant pathways. In immune cells, ferroptosis susceptibility varies by cell types, lipid composition, and metabolic demands, influencing immune responses in cancer, infections, and autoimmune …

kr (code pays fourni par la source)

Control of T-cell immunity by fatty acid metabolism

Y. Lee, Yeonseok Chung

Fatty acids play critical roles in maintaining the cellular functions of T cells and regulating T-cell immunity. This review synthesizes current research on the influence of fatty acids on T-cell subsets, including CD8+ T cells, TH1, TH17, Treg (regulatory T cells), and …

kr (code pays fourni par la source)

HDAC6 mediates NLRP3 inflammasome activation in the pathogenesis of diabetic retinopathy

Junsik Kim, Jae Hyun Jun, Jeong-Mi Lee, Eunae Kim et autres

kr (code pays fourni par la source)

Immunometabolic regulation of germinal centers and its implications for aging

Daehong Kim, Jaemin Kim, Hyeonuk Yeo, Yeonseok Chung

Éthiopie, pr (code pays fourni par la source)

NRF2 is a spatiotemporal metabolic hub essential for the polyfunctionality of Th2 cells

Garam Choi, Hye-Yeon Ju, Jahyun Bok, Jungseo Choi et autres

T cells differentiate into IL-4-producing Th2 cells in lymph nodes, which later transform into polyfunctional Th2 cells producing IL-5 and IL-13 in inflamed tissues. However, the precise mechanism underlying their polyfunctionality remains elusive. In this study, we elucidate the pivotal role of …

kr (code pays fourni par la source)

B lymphocytes acquire myeloid and autoimmune phenotypes via the downregulation of lymphocyte-specific protein-1

Naeun Lee, Bong‐Ki Hong, Sungyong You, Riri Kwon et autres

Abstract Actin-binding proteins (ABPs) have been established as important mediators of immune homeostasis, but their effects on lymphocytes are poorly understood. Here, we demonstrated that LSP1, an ABP, is a master regulator for innate immune responses in B lymphocytes. Lsp1 deficiency in …

kr, us, Éthiopie, fr, ca (code pays fourni par la source)