Alexios A. Panoutsopoulos

Vesicular Glutamate Release Is Necessary for Neural Tube Formation

Raman Goyal, Patricio A. Castro, Jacqueline B. Levin, Sangwoo Shim et autres

The brain and spinal cord originate from a neural tube that is preceded by a flat structure known as the neural plate during early embryogenesis. In humans, failure of the neural plate to convert into a tube by the fourth week of …

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Noncanonical function of folate through folate receptor 1 during neural tube formation

Olga A. Balashova, Alexios A. Panoutsopoulos, Olesya Visina, Jacob Selhub et autres

Abstract Folate supplementation reduces the occurrence of neural tube defects (NTDs), birth defects consisting in the failure of the neural tube to form and close. The mechanisms underlying NTDs and their prevention by folate remain unclear. Here we show that folate receptor …

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Non-canonical function of folate/folate receptor 1 during neural tube formation

Olga A. Balashova, Alexios A. Panoutsopoulos, Olesya Visina, Jacob Selhub et autres

Abstract Folate supplementation reduces the occurrence of neural tube defects, one of the most common and serious birth defects, consisting in the failure of the neural tube to form and close early in pregnancy. The mechanisms underlying neural tube defects and folate …

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Calcium dynamics at the neural cell primary cilium regulate Hedgehog signaling–dependent neurogenesis in the embryonic neural tube

Sangwoo Shim, Raman Goyal, Alexios A. Panoutsopoulos, Olga A. Balashova et autres

The balance between neural stem cell proliferation and neuronal differentiation is paramount for the appropriate development of the nervous system. Sonic hedgehog (Shh) is known to sequentially promote cell proliferation and specification of neuronal phenotypes, but the signaling mechanisms responsible for the …

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Supplementary Methods, Table 1, Figures 1-2 from Enhancement of TGF-β Signaling Responses by the E3 Ubiquitin Ligase Arkadia Provides Tumor Suppression in Colorectal Cancer

Vikas Sharma, Anna G. Antonacopoulou, Shinya Tanaka, Alexios A. Panoutsopoulos et autres

Supplementary Methods, Table 1, Figures 1-2 from Enhancement of TGF-β Signaling Responses by the E3 Ubiquitin Ligase Arkadia Provides Tumor Suppression in Colorectal Cancer

Supplementary Methods, Table 1, Figures 1-2 from Enhancement of TGF-β Signaling Responses by the E3 Ubiquitin Ligase Arkadia Provides Tumor Suppression in Colorectal Cancer

Vikas Sharma, Anna G. Antonacopoulou, Shinya Tanaka, Alexios A. Panoutsopoulos et autres

Supplementary Methods, Table 1, Figures 1-2 from Enhancement of TGF-β Signaling Responses by the E3 Ubiquitin Ligase Arkadia Provides Tumor Suppression in Colorectal Cancer

Data from Enhancement of TGF-β Signaling Responses by the E3 Ubiquitin Ligase Arkadia Provides Tumor Suppression in Colorectal Cancer

Vikas Sharma, Anna G. Antonacopoulou, Shinya Tanaka, Alexios A. Panoutsopoulos et autres

Abstract TGF-β signaling provides tumor protection against colorectal cancer (CRC). Mechanisms that support its tumor-suppressive properties remain unclear. The ubiquitin ligase Arkadia/RNF111 enhances TGF-β signaling responses by targeting repressors of the pathway for degradation. The corepressors SnoN/Ski, critical substrates of Arkadia, complex …

Data from Enhancement of TGF-β Signaling Responses by the E3 Ubiquitin Ligase Arkadia Provides Tumor Suppression in Colorectal Cancer

Vikas Sharma, Anna G. Antonacopoulou, Shinya Tanaka, Alexios A. Panoutsopoulos et autres

Abstract TGF-β signaling provides tumor protection against colorectal cancer (CRC). Mechanisms that support its tumor-suppressive properties remain unclear. The ubiquitin ligase Arkadia/RNF111 enhances TGF-β signaling responses by targeting repressors of the pathway for degradation. The corepressors SnoN/Ski, critical substrates of Arkadia, complex …

Correction: WDFY3 mutation alters laminar position and morphology of cortical neurons

Zachary A. Schaaf, Lyvin Tat, Noemi Cannizzaro, Alexios A. Panoutsopoulos et autres

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WDFY3 mutation alters laminar position and morphology of cortical neurons

Zachary A. Schaaf, Lyvin Tat, Noemi Cannizzaro, Alexios A. Panoutsopoulos et autres

BACKGROUND: Proper cerebral cortical development depends on the tightly orchestrated migration of newly born neurons from the inner ventricular and subventricular zones to the outer cortical plate. Any disturbance in this process during prenatal stages may lead to neuronal migration disorders (NMDs), …

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Wdfy3 regulates glycophagy, mitophagy, and synaptic plasticity

Eleonora Napoli, Alexios A. Panoutsopoulos, Patricia Kysar, Nathaniel Satriya et autres

Autophagy is essential to cell function, as it enables the recycling of intracellular constituents during starvation and in addition functions as a quality control mechanism by eliminating spent organelles and proteins that could cause cellular damage if not properly removed. Recently, we …

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Organoids, Assembloids, and Novel Biotechnology: Steps Forward in Developmental and Disease-Related Neuroscience

Alexios A. Panoutsopoulos

In neuroscience research, the efforts to find the model through which we can mimic the in vivo microenvironment of a developing or defective brain have been everlasting. While model organisms are used for over a hundred years, many more methods have been …

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