Xiang Chen

Transaldolase 1 impacts Parkinson’s disease pathogenesis via metabolic reprogramming and autophagy-lysosomal pathway

Zixin Tan, Huimin Hu, Hao Chen, Yuwan Lin et autres

Parkinson's disease (PD) progression involves dopaminergic neurodegeneration and pathological α-synuclein aggregation, processes linked to metabolic dysregulation and autophagy-lysosomal pathway (ALP) impairment. Transaldolase1 (TAL1) is a key enzyme of the pentose phosphate pathway. While elevated TAL1 protein levels have been observed in postmortem …

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ATP6V0A1 protects dopaminergic neurons via the autophagy–lysosomal pathway in Parkinson’s disease

Yuwan Lin, Zixin Tan, Wenfeng Ye, Weimin Li et autres

Parkinson’s disease is the second most common neurodegenerative disorder. ATPase H+ transporting V0 subunit A1 (ATP6V0A1) is a component of vacuolar H+-ATPase (V-ATPase), an ATP-dependent proton pump. Our previous research identified an association between the ATP6V0A1 rs601999 variant and Parkinson’s disease; however, …

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Correlation of SV2C rs1423099 single nucleotide polymorphism with sporadic Parkinson's disease in Han population in Southern China

Zixin Tan, Yuwan Lin, Miaomiao Zhou, Wenyuan Guo et autres

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Editorial: Mitochondrial and lysosomal dysfunction in neurodegenerative diseases: Molecular mechanisms and therapeutic strategies

Xiang Chen, Yousheng Xiao, Pu Jiali, Pei Zhong

EDITORIAL article Front. Aging Neurosci., 04 October 2022Sec. Cellular and Molecular Mechanisms of Brain-aging Volume 14 - 2022 | https://doi.org/10.3389/fnagi.2022.1029440

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Association of CLU gene polymorphism with Parkinson's disease in the Chinese Han population

Yuwan Lin, Lin Lü, Miaomiao Zhou, Hanqun Liu et autres

BACKGROUND: Clusterin (CLU) plays important role in the pathology of neurodegenerative disorders. Recently, a genetic variant of CLU rs9331896 has been reported as a risk estimate for Alzheimer's disease (AD). However, the association between this variant and the risk of Parkinson's disease …

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Relationship between variants of 17 newly loci and Parkinson's disease in a Chinese population

Xiang Chen, Yousheng Xiao, Wenyuan Guo, Miaomiao Zhou et autres

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Impacts of relaxation training on psychological health in young nurses

Xiang Chen, Changchun Zhang, Guimei Wang, Benmin Yu et autres

Objective To understand mental health of young nurses and coping style, to explore the influence about relaxation training to their mental health. Methods A total of 90 nurses within five years work experience were randomly divided into stretch-release relaxation, cognitive relaxation training …

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Effects of psychological intervention on mental state and quality of life in patients with chronic heart failure

Xiang Chen

Objective To study the effects of psychological intervention on mental state and quality of life in patients with chronic heart failure(CHF).Methods Sixty pationts cases with CHF were randomly divided into intervention group and control group. HRSD,HAMA,and SF-36 were evaluated.Results The total score …