Xinli Ma

Identification and functional characterization of GhCSLD3, a negative regulator of fruit branch elongation in cotton (Gossypium hirsutum L.)

Xinli Ma, Yuan Tian, Han Geng, Zhen Peng et autres

The fruit branch is a critical determinant of plant architecture in cotton, and its length optimization is pivotal for high-density planting and mechanical harvesting. However, the genetic mechanisms governing fruit branch length (FBL) are not fully elucidated. In this study, an F …

cn (code pays fourni par la source)

Structure-guided discovery of isoindolinone–triazolopyrimidine hybrids as potential Skp1–Skp2 inhibitors: Integrated docking, molecular dynamics, and machine learning modelling

Yalnaz Naseem, Jianshu Dong, Ke Yang, Cong Han et autres

This study presents a structure-guided computational investigation of reported isoindolinone/[1,2,4]triazolo[1,5-a]pyrimidine derivatives as potential ligands targeting the Skp1–Skp2 complex. Molecular docking, molecular dynamics (MD) simulations, MM/PBSA free-energy analysis, and machine-learning-based activity modelling were integrated to examine ligand-recognition features and binding stabilization within the …

cn, pk (code pays fourni par la source)

基于FAERS数据库的Rybrevant不良反应特征与信号检测研究

赵杰, 张艳萍, 姜旭, 康利波 et autres

目的了解Rybrevant（amivantamab-vmjw）不良反应特征，对于优化患者管理和提升治疗安全性具有重要意义。方法本研究利用美国FDA不良事件报告系统（FAERS）数据库，收集2021年至2023年期间与Rybrevant相关的不良反应报告。采用多种比例失衡分析方法，包括报告比值比（ROR）、比例报告率、贝叶斯置信传播神经网络及经验贝叶斯几何均值，识别并评估潜在安全性信号。结果共纳入415份不良事件报告，涉及871个首选术语。最主要的不良反应包括痤疮样皮炎（ROR：61.29）、肺炎（ROR：34.29）及输注相关反应（ROR：128.89）。同时亦有严重结局的报告，其中住院发生率为21.83%，死亡率为13.97%。本研究还识别出若干新型不良反应，包括肛门溃疡（ROR：307.86）、血清白蛋白降低（ROR：40.13）及低白蛋白血症（ROR：29.77）。讨论Rybrevant具有独特的不良反应特征，主要集中在皮肤毒性和呼吸系统毒性方面。持续的药物警戒和前瞻性管理措施对于平衡治疗风险、保障患者安全至关重要。

Transformer-based multimodal precision intervention model for enhancing diaphragm function in elderly patients

Xinli Ma, Jie Zhao, Fan Li, Jing Jia et autres

Diaphragm dysfunction represents a significant complication in elderly patients undergoing mechanical ventilation, often resulting in extended intensive care stays, unsuccessful weaning attempts, and increased healthcare expenditures. To address the deficiency of precise, real-time decision support in this context, a novel artificial intelligence …

cn (code pays fourni par la source)

The role of HOXA1 in cancer and targeted therapy

Jianshu Dong, Huimin Gong, Jian Li, Xinli Ma et autres

nz, cn (code pays fourni par la source)

Iron, selenium, copper and magnesium in critical care: Impact on acquired weakness risk through Mendelian randomization

H. Sun, Yuwei Sun, Jinxin Zhang, Xinli Ma

BACKGROUND: Trace elements play a crucial role in the health of critically ill patients, yet their impact on acquired weakness remains unclear. AIM: This study utilized Mendelian randomization (MR) to explore the relationship between iron, selenium, copper, magnesium, zinc and debilitation risk …

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Genome-wide identification of SERKs in four Gossypium species reveals GhBAK1 potentially promotes cotton defoliation

Na Qin, Yuan Tian, Abdul Rehman, Xinli Ma et autres

Cotton ( Gossypium spp.) holds significant global industrial importance as a primary textile fiber crop. Using chemical defoliants to speed up the shedding of leaves before machine harvesting is a necessary agricultural practice in cotton production. Somatic Embryogenesis Receptor Kinases (SERKs) have …

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Evaluation and selection of digestive tract construction procedures after proximal gastrectomy

Xiaoqi Li, Xinli Ma, Jiangfeng Qiu

Insights into the distinct membrane targeting mechanisms of WDR91 family proteins

Xinli Ma, Jian Li, Nan Liu, Surajit Banerjee et autres

cn, us (code pays fourni par la source)

The genetic basis of leaf hair development in upland cotton ( Gossypium hirsutum )

Xiaoyang Wang, Panhong Dai, Hongge Li, Jingjing Wang et autres

Trichomes, which originate from the epidermal cell of aerial organs, provide plants with defense and secretion functions. Although numerous genes have been implicated in trichome development, the molecular mechanisms underlying trichome cell formation in plants remain incompletely understood. Here, we using genome-wide …

cn (code pays fourni par la source)

Mutations found in cancer patients compromise DNA binding of the winged helix protein STK19

Jian Li, Xinli Ma, Xiaoyu Wang, Xiaotong Hu et autres

Serine/threonine protein kinase 19 (STK19) has been reported to phosphorylate and activate oncogenic NRAS to promote melanomagenesis. However, concerns have been raised about whether STK19 is a kinase. STK19 has also been identified as a putative factor involved in the transcription-coupled nucleotide …

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Exploring the regulatory role of non-coding RNAs in fiber development and direct regulation of GhKCR2 in the fatty acid metabolic pathway in upland cotton

Jingjing Wang, Xiaoyang Wang, Liyuan Wang, Mian Faisal Nazir et autres

cn (code pays fourni par la source)