Xiaotong Hu

Blood-Derived Systemic Inflammatory Biomarkers and Intraocular Pressure in a Routine Health Examination Population

Hui Li, Qian Xie, Chunmao Jiang, Jie Wan et autres

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Dose–response association between metabolic syndrome component count and metabolic dysfunction-associated fatty liver disease, and independent graded association of visceral fat area: a cross-sectional study in a health-checkup population

Qian Xie, Hui Li, Xiaotong Hu, Jie Wan et autres

Objectives: To quantify the dose-response association between metabolic syndrome (MetS) component count and metabolic dysfunction-associated fatty liver disease (MAFLD), and to evaluate the independent graded association of visceral fat area (VFA) with MAFLD. Materials and methods: This single-center cross-sectional study enrolled adults …

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Comprehensive Genomic Profiles of Patients With Biliary Tract Cancer

Xia Yang, Tao Zhu, Xiaotong Hu, Z N Jiang et autres

PURPOSE: Biliary tract cancer (BTC) represents a heterogeneous disease with highly lethal malignancy and poor clinical outcomes. Here, we aimed to evaluate its genomic profiles to promote the development of precision medicine for BTC. MATERIALS AND METHODS: Genomic analysis of 134 BTC …

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Bacteria-derived equol alleviates Aβ toxicity in C. elegans through PEK-1-associated UPRer activation

Wei Yao, M.X. Qu, Cui Deng, Chongyang Zhang et autres

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Dose-response association between metabolic abnormality burden and intraocular pressure in a population undergoing routine health examinations: a cross-sectional study

Hu Li, Chunmao Jiang, Xiaotong Hu, Xia Gao et autres

OBJECTIVE: To investigate the association between metabolic risk burden and intraocular pressure in individuals undergoing routine health examinations, and to assess the presence of a dose-response relationship, thereby informing IOP risk stratification in health check-up settings. METHODS: This cross-sectional study included 2,048 …

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Transcriptome‐Wide N7 ‐Methylguanosine ( m7G ) Map Profiling Reveals the Regulatory Role of m7G in Atherosclerosis

Tao Geng, Kaiyan Wang, Hui Wang, Tianshu Gu et autres

The uptake of modified lipoproteins by macrophages to form foam cells is a crucial step in atherosclerosis (AS) development. N7-methylguanosine (m7G) is frequently methylated internally in eukaryotic RNA transcripts and plays a crucial role in various processes. This study aimed to investigate …

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Effects of Qixuekang oral liquid in leukopenia during chemotherapy and radiotherapy in patients with malignant tumors: A randomized, double-blind, placebo-controlled, multicenter study

Yafang Cai, Peng Xue, Xiaotong Hu, Huijie Wang et autres

To assess the efficacy and safety of Qixuekang oral liquid in the treatment of leukopenia during chemotherapy and radiotherapy. This randomized, double-blind, placebo-controlled, multicenter clinical trial was conducted between July 2018 and May 2021. A total of 234 patients with malignant tumors …

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The relationship between the treatment frequency and efficacy of acupuncture: A scoping review of clinical trials

Xiaotong Hu, Jingli Xing, Yiying Wang, Wei Yu et autres

OBJECTIVE: To consolidate and analyze the existing evidence on the relationship between acupuncture treatment frequency and its clinical efficacy, clarify research status, trends, and core issues, and provide evidence-based insights for optimizing acupuncture treatment protocols. METHODS: Following the Arksey and O'Malley scoping …

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KDM4A serves as an α-tubulin demethylase regulating microtubule polymerization and cell mitosis

Su-Hao Cao, Shaogang Wang, Xuan Xie, Xiaotong Hu et autres

Posttranslational modifications of tubulin give microtubule distinct properties to support diverse cellular functions. Trimethylation on lysine-40 of α-tubulin (α-TubK40me3) is involved in cell division and neuronal development. The “writer” (SETD2) and “reader” (PBRM1) of α-TubK40me3 have been identified. However, the “eraser” of …

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Discovery of Novel Potent Triple IKZF1/2/3 Degraders for the Treatment of Hematological Cancers

Ting Wei, Shiyang Sun, Xiaotong Hu, Pengli Wei et autres

Abstract Immunomodulatory drugs (IMiDs) are widely utilized therapies in multiple hematological cancers; however, their clinical application is frequently constrained by drug resistance. Here, though screening of diverse cereblon (CRBN) binders, comprehensive structure–activity relationships (SAR) analyses and systematic degradation profiling, MGD-22, a potent …

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The role of Genipin crosslinked extracellular matrix loaded bFGF in the repair of peripheral nerve injury

Yijia Zhang, Gaobao Zhuo, Fangzheng Yu, Xiaodan Xu et autres

BACKGROUND: Biomaterials have been extensively utilized in the field of tissue regeneration and repair. The objective of this study was to develop and assess the efficacy of ECM-G@bFGF in the repair of sciatic nerve injuries. METHODS: The extracellular matrix (ECM) of the …

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Mapping the Impact of Treatment Frequency on Acupuncture Efficacy: A Scoping Review of Clinical Trials

Guodong Li, Xiaotong Hu, Jingli Xing, Yiying Wang et autres

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