Yucheng Ma

Multi-omics analysis identifies a microbiota–bile acid–TLR signaling axis driving bladder injury in interstitial cystitis

Liao Peng, Jia-wei Chen, Yuan-Zhuo Chen, Xing-peng Di et autres

Hunner-type interstitial cystitis/bladder pain syndrome (HIC) is a debilitating condition defined by bladder pain and urinary urgency, yet its upstream drivers remain poorly understood. To identify upstream mechanisms that exacerbate urothelial injury, here we apply an integrative multi-omics framework combining metagenomic sequencing, …

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ER stress induced extracellular vesicles secretion from macrophages promotes calcium oxalate crystals formation in kidney

Yiqiong Yuan, Yucheng Ma, Lunzhi Dai, Xi Jin et autres

Macrophages are involved in the development of kidney stone disease, and substantial research suggests that macrophage-derived extracellulr vesicles (Mφ-EVs) may play a pivotal role in this process. However, the impact of Mφ-EVs on kidney stone formation and the mechanisms of EVs secretion …

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Association between high fat diet and kidney stones based on the National Health and Nutrition Examination Survey (NHANES) 2007–2020: a cross-sectional study

Chao Cheng, Puhan Li, Yexian Yuan, Yaohui Jiang et autres

Background: The global incidence of kidney stones (KS) has increased markedly, affecting approximately 9% of the world's population. The well-established role of high fat diet (HFD) in promoting metabolic disorders through mechanisms such as chronic inflammation and gut dysbiosis, combined with clinical …

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Discovery of potent ClpX modulators with pronounced antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA)

Yan Liu, Jin Li, Yucheng Ma, Wenfang Gao et autres

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Gut microbiota-bile acid crosstalk contributes to calcium oxalate nephropathy through Hsp90α-mediated ferroptosis

Linhu Liu, Yucheng Ma, Zhongyu Jian, Banghua Liao et autres

The gut microbiota and its metabolites have been implicated in calcium oxalate (CaOx) nephrolithiasis, while the precise mechanism remains unclear. We report that the gut microbiota dysbiosis in patients with CaOx nephrolithiasis results in an elevated level of deoxycholic acid (DCA) and …

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Compared with assessment via endoscopic examination, assessment through the examination of resected regional lymph nodes can significantly reduce the mortality rate of lung cancer patients: a retrospective study of 222,563 participants from the SEER database

Jiayue Ye, Yucheng Ma, Jia-Cong Liu, Yonghui Wang et autres

Background: Lymph node assessment is essential for determining treatment and evaluating the surgical scope in patients with lung cancer, thus significantly impacting survival prognosis. Surgical resection and endoscopic biopsy are the primary methods for obtaining lymph node samples, yet it remains controversial …

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Increased mortality in lung cancer patients with same-lobe, multi-lobe, or mixed nodules: a retrospective study of 166,097 participants from the SEER database

Jiayue Ye, Jia-Cong Liu, Yucheng Ma, Yiqing Wang et autres

Background: Lung cancer is a leading cause of cancer-related deaths globally, with a particularly high burden in China and a poor prognosis mainly due to late-stage diagnosis and limited effective treatments. Large-sample survival analyses are lacking for patients with lung cancer who …

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Structural characterization, functional properties, and antioxidant potential of a novel mannogalactoglucan from Boletus auripes peck

Yucheng Ma, Yu Mao, Li Liu, Banghua Liao et autres

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Efficacy and safety of anlotinib plus EGFR tyrosine kinase inhibitors in slow- or locally progressing non-small cell lung cancer after adjuvant therapy

Jiayue Ye, Jia-Cong Liu, Yucheng Ma, Wang Lv et autres

Background: Anlotinib, a small-molecule tyrosine kinase inhibitor (TKI), suppresses angiogenesis and tumor progression. As the mechanisms underlying the resistance to epidermal growth factor receptor (EGFR)-TKIs are complex and diverse, further exploration of new treatment strategies is necessary. Combination therapy with EGFR-TKIs and …

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Single-Cell RNA Sequencing Analysis Reveals the Role of Macrophage-Mediated CD44–AKT–CCL2 Pathways in Renal Tubule Injury during Calcium Oxalate Crystal Formation

Xi Jin, Zhongyu Jian, Yucheng Ma, Jun Wen et autres

Oxalate-induced crystalline kidney injury is a common form of crystal nephropathy. The accumulation of calcium oxalate (CaOx) crystal could lead to renal epithelium injury and inflammation. The underlying cellular events in kidney after CaOx crystal formation are largely unknown. This study was …

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Exploring the Health Benefits of Boletus aereus Polysaccharides: Extraction, Structural Characterization, and Antiproliferative Properties against Non-Hodgkin’s Lymphomas (NHLs)

Haidi Wang, Linyu Yang, Qiang Qiu, Qianru Rao et autres

Boletus aereus Fr. ex Bull. stands out as a delectable edible mushroom with high nutritional and medicinal values, featuring polysaccharides as its primary nutrient composition. In our continuous exploration of its beneficial substances, a novel polysaccharide (BAPN-1) with a molecular weight of …

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A novel T1a/b classification for testicular cancer: not only seminoma

Puhan Li, Yucheng Ma, Banghua Liao

Background: edition of the American Joint Committee on Cancer (AJCC) manual divides T1 stage testicular cancer into T1a and T1b, but it is only applicable to seminoma. The purpose of this observational study is to discuss further the possibility of extending this …

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