Jin Li

OsGSK2‐OsTCP19 Module Integrates Nitrogen and Brassinosteroid Signaling to Regulate Nitrogen Utilization and Root Growth in Rice

Yongqiang Liu, Jin Li, Xiaohui Ma, Xiaohan Wang et autres

Nitrogen (N) and brassinosteroids (BRs) are key regulators of plant developmental plasticity in fluctuating nutrient environments, yet the direct molecular link coordinating these two signaling pathways remains elusive. Here, we report a synergistic interplay between nitrate and BR signaling that governs N …

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Efficacy and safety of triweekly cetuximab in combination with capecitabine as first-line maintenance treatment for KRAS/BRAF wild-type metastatic colorectal cancer: A phase Ib dose-escalation study.

Xiaoyu Xie, Ziqin Lin, Jin Li, Yuqian Xie et autres

124 Background: The every-two-weeks (Q2W) dosing schedule of cetuximab plus fluorouracil-based agents is a commonly used maintenance therapy for KRAS/BRAF wild-type metastatic colorectal cancer (mCRC), but current regimens are limited by infusion burden and schedule misalignment. A triweekly cetuximab schedule synchronized with …

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Discovery of potent ClpX modulators with pronounced antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA)

Yan Liu, Jin Li, Yucheng Ma, Wenfang Gao et autres

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Host-directed therapeutic targets in macrophages and their ligands against mycobacteria tuberculosis

Jin Li, Yanmei Wang, Lei He, Luchuan Yang et autres

ABSTRACT Although current combination regimens of antibiotics have significantly improved tuberculosis (TB) cure rates, substantial challenges persist in the global effort to end TB. These include poor patient compliance, the emergence of drug-resistant strains due to prolonged treatments, and the persistence of …

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Uncovering biomarkers and pathways in oral squamous cell carcinoma through integrated lncRNA-mRNA regulatory network analysis

ShiWei Liu, Jin Li, Qing Shao, J J Chen et autres

OBJECTIVE: This study aimed to identify potential biomarkers and elucidate molecular mechanisms in oral squamous cell carcinoma (OSCC) by leveraging an integrated bioinformatics approach. METHODS: We conducted high-throughput RNA sequencing on OSCC and adjacent normal tissues to profile mRNA and lncRNA expression. …

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Simultaneous stereoisomeric preconcentration and determination of alkaloids and stereoisomers in Uncariae ramulus cum uncis using field enhanced sample injection and dynamic pH junction sweeping method by cyclodextrin electrokinetic chromatography

Wenping Liu, Yaqi Yao, Jiake Wen, Liping Huang et autres

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Development of a novel prognostic signature derived from super-enhancer-associated gene by machine learning in head and neck squamous cell carcinoma

An Wang, He X, Jin Li, Pengfei Diao et autres

Dysregulated super-enhancer (SE) results in aberrant transcription that drives cancer initiation and progression. SEs have been demonstrated as novel promising diagnostic/prognostic biomarkers and therapeutic targets across multiple human cancers. Here, we sought to develop a novel prognostic signature derived from SE-associated genes …

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An Integrative Probe for Tumor Therapy and Dual-Modal Self-Evaluation Imaging of Therapeutic Efficacy

Minghui Wang, Wenbin Liu, Bo Li, Wujuan Zhu et autres

Currently, independent tumor therapy and evaluation methods can not achieve real-time evaluation. Therefore, development of a self-evaluation strategy is urgently needed. To the best of our knowledge, there is no multimodal self-evaluation strategy. Herein, we design an integrative probe ( CPT-SS-DEVD-HCy ) …

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Trends in antimicrobial resistance in Enterobacterales isolated from children: data from the China Antimicrobial Surveillance Network (CHINET) from 2015–2021

Fen Pan, Chun Wang, Yang Yang, Yan Guo et autres

Abstract Antimicrobial resistance poses a significant threat to global public health, especially for Enterobacterales. In this study, we investigated the distribution and antimicrobial resistance of Enterobacterales in children in the China Antimicrobial Surveillance Network (CHINET) in 2015–2021. In total, 81,681 strains isolated …

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Organic fertilizer enhances soil aggregate stability by altering greenhouse soil content of iron oxide and organic carbon

Lijun Ren, Han Yang, Jin Li, Nan Zhang et autres

Both soil organic carbon (SOC) and iron (Fe) oxide content, among other factors, drive the formation and stability of soil aggregates. However, the mechanism of these drivers in greenhouse soil fertilized with organic fertilizer is not well understood. In a 3-year field …

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Degradation of Polypropylene by the Pseudomonas aeruginosa Strains LICME WZH-4 and WGH-6

Panlin Wang, Jindi Zhao, Yongqiang Ruan, Xinyi Cai et autres

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Visible‐Wavelength Spatiotemporal Mode‐Locked Fiber Laser Delivering 9 ps, 4 nJ Pulses at 635 nm

Qiujun Ruan, Xiaosheng Xiao, Jinhai Zou, Hang Wang et autres

Abstract Spatiotemporal mode‐locking (STML) in fiber lasers are of interest in applications such as optical communications, nonlinear imaging, and precision machining. To date, STML fiber lasers in the near‐infrared region have been well demonstrated, yet operation at visible wavelengths is still challenging. …

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