Eunyoung Choi

Epithelial WNT secretion drives niche escape of developing gastric cancer

Jaehun Lee, Soomin Kim, Youngchul Oh, Stephan R. Jahn et autres

BACKGROUND: WNT signaling plays a key role in maintaining the gastric epithelium and promoting tumorigenesis. However, how gastric tumors achieve WNT niche independence remains unclear, as mutations on APC or CTNNB1-common mechanisms of ligand-independent WNT activation in colorectal cancer-are infrequent in gastric …

kr, de, at, mx, us (code pays fourni par la source)

926 Novel hydrophilic nanoparticle (HNP) platform for mRNA cancer vaccine delivery elicits anti-tumor efficacy in preclinical models

Hyunho Park, Youngdong Choi, Eunyoung Choi, Carlos Medina et autres

Background mRNA-based cancer vaccines represent a promising therapeutic approach due to their ability to encode virtually any tumor antigen and rapidly stimulate antigen-specific immune responses. We developed hydrophilic nanoparticles (HNPs) for non-hepatic, targeted delivery of mRNA to antigen-presenting cells (APCs), particularly in …

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A Cell Marker Atlas to Distinguish Metaplastic Transitions in Human Esophagus and Stomach

Karen J. Dunbar, Su‐Hyung Lee, Yoonkyung Won, Emily M. Esquea et autres

Metaplasia is an adaptative response to injury and inflammation and can be a precursor to dysplasia and cancer. Metaplasia in the esophagus, termed Barrett's esophagus, is the replacement of the stratified squamous epithelium by glandular tissue comprising gastric and/or intestinal cell lineages. …

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1260 TWO DIFFERENT ROLES OF THE CHROMATIN REMODELING COMPONENT ARID1A IN NEOPLASTIC TRANSFORMATION OF GASTRIC MUCOSA

Yoonkyung Won, Eunyoung Choi

Mo1217 ALTERATIONS IN DNMT1 EXPRESSION DURING METAPLASIA PROGRESSION

Halee T. Scott, Brianna M. Caldwell, Eunyoung Choi

130 LOSS OF SOX9 IN SPEM CELLS SUPPRESSES METAPLASIA PROGRESSION

Alexis Guenther, Yoonkyung Won, Brianna M. Caldwell, Eunyoung Choi

Su1218 CORTACTIN DETERMINES MEMBRANE DYNAMICS AND EXOSOME SECRETION IN DYSPLASTIC CELLS DURING DYSPLASIA EVOLUTION TO ADENOCARCINOMA

Alexis Guenther, Jimin Min, Eunyoung Choi

344: TROP2+CD133+CD166+ DYSPLASTIC STEM CELLS ARE DE NOVO STEM CELLS DRIVING DYSPLASIA TRANSITION TO GASTRIC CANCER

Jimin Min, Changqing Zhang, Jarrett Bliton, Brianna M. Caldwell et autres

970: DISCRETE FIBROBLAST SUBSETS NURTURE GASTRIC CARCINOGENESIS

Su‐Hyung Lee, Ela W. Contreras Panta, David L. Gibbs, Yoonkyung Won et autres

Tu1303: HEPATOCYTE-SPECIFIC LOSS OF LAP2α PROTECTS AGAINST HIGH FAT DIET-INDUCED HEPATIC STEATOSIS IN MICE

Kapil K. Upadhyay, Eunyoung Choi, Roland Foisner, M. Bishr Omary et autres

Author response for "Effect of telmisartan on experimental model of periodontitis in mice"

So Jung Jeon, Yo Han Lee, Bo Ram Keum, Eunyoung Choi et autres

Overexpression of SOD in retina: Need for increase in H2O2-detoxifying enzyme in same cellular compartment

Zhihao Wu, Brian C. Oveson, Eunyoung Choi, Sun Young Lee et autres

In retinitis pigmentosa (RP), various mutations cause rod photoreceptor cell death leading to increased oxygen levels in the outer retina, progressive oxidative damage to cones, and gradual loss of cone cell function. We have been exploring the potential of overexpressing components of …