Kapil K. Upadhyay

The inner nuclear membrane protein SUN1 regulates cullin-3 neddylation to maintain insulin signaling

Kapil K. Upadhyay, Y Z Yang, Aren Shah, Venkatesha Basrur et autres

Abstract Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most prevalent chronic liver disease and strongly linked to obesity and insulin resistance. We previously reported that the common nuclear envelope variant rs6461378 (g.842031C>T; SUN1 H118Y) associated with MASLD and related traits including …

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Melatonin improves neuro-behavioral perturbations in diet/photoperiod induced chronodisruption

Aliasgar Vohra, Rhydham Karnik, Hitarthi Vyas, Shruti Kulshrestha et autres

Abstract Endogenous circadian oscillators regulate learning, cognitive performance and memory are disrupted due to circadian shifts. High-fat-high-fructose (H) diet, photoperiodic shifts induced chronodisruption (CD) and a combination (HCD) causes neurobehavioral perturbations wherein; the merits of exogenous melatonin in alleviating the said behavioral …

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LMNA R644C Associates With Hepatic Steatosis in a Large Cohort and Increases Cellular Lipid Droplet Accumulation in Vitro

Kapil K. Upadhyay, Yanhua Chen, Xiaomeng Du, Lishi Yin et autres

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Bioactive Fractions Isolated from Harungana madagascariensis Lam. and Psorospermum aurantiacum Engl. Regulate Collagen and Melanin Biosynthesis Gene Expression in UVB-irradiated Cells with Additional Anti-inflammatory Potential

Jacqueline Njikam Manjia, Apeksha Joshi, Emmanuel Mfotie Njoya, Kapil K. Upadhyay et autres

`Background: Harungana madagascariensis (HM) and Psorospermum aurantiacum (PA), used traditionally for skin care, have been reported to upregulate the expression of intracellular antioxidant genes, thereby preventing melanoma and protecting fibroblast cell lines from Ultraviolet B (UVB)-induced intracellular oxidative stress. Aims: This investigation …

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Melatonin-mediated corrective changes in gut microbiota of experimentally chronodisrupted C57BL/6J mice

Aliasgar Vohra, Rhydham Karnik, Mansi Desai, Hitarthi Vyas et autres

Chronic consumption of a high-calorie diet coupled with an altered sleep-wake cycle causes disruption of circadian clock that can impact the gut microbiome leading to metabolic syndrome and associated diseases. Herein, we investigate the effects of a high fat high fructose diet …

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LMNA R644C associates with hepatic steatosis in a large cohort and increases cellular lipid droplet accumulation in vitro

Kapil K. Upadhyay, Xiaomeng Du, Yanhua Chen, Elizabeth K. Speliotes et autres

Summary The R644C variant of lamin A is controversial, as it has been linked to multiple phenotypes in familial studies, but has also been identified in apparently healthy volunteers. Here we present data from a large midwestern US cohort showing that this …

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miR34a-5p impedes CLOCK expression in chronodisruptive C57BL/6J mice and potentiates pro-atherogenic manifestations

Hitarthi Vyas, Aliasgar Vohra, Kapil K. Upadhyay, Menaka C. Thounaojam et autres

INTRODUCTION: Altered circadian rhythms underlie manifestation of several cardiovascular disorders, however a little is known about the mediating biomolecules. Multiple transcriptional-translational feedback loops control circadian-clockwork wherein; micro RNAs (miRNAs) are known to manifest post transcriptional regulation. This study assesses miR34a-5p as a …

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A common variant that alters SUN1 degradation associates with hepatic steatosis and metabolic traits in multiple cohorts

Kapil K. Upadhyay, Xiaomeng Du, Yanhua Chen, Brandon Buscher et autres

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Hepatocyte-specific loss of LAP2α protects against diet-induced hepatic steatosis, steatohepatitis, and fibrosis in male mice

Kapil K. Upadhyay, Eun-Young Choi, Roland Foisner, M. Bishr Omary et autres

The nuclear envelope and lamina regulate lipid metabolism and susceptibility to nonalcoholic steatohepatitis (NASH), but the role of the nuclear lamin-binding protein LAP2α in NASH has not been explored. Our data demonstrate that hepatocyte-specific loss of LAP2α protects against diet-induced hepatic steatosis, …

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CORM-A1 Alleviates Pro-Atherogenic Manifestations via miR-34a-5p Downregulation and an Improved Mitochondrial Function

Hitarthi Vyas, Ravirajsinh N. Jadeja, Aliasgar Vohra, Kapil K. Upadhyay et autres

Atherogenesis involves multiple cell types undergoing robust metabolic processes resulting in mitochondrial dysfunction, elevated reactive oxygen species (ROS), and consequent oxidative stress. Carbon monoxide (CO) has been recently explored for its anti-atherogenic potency; however, the effects of CO on ROS generation and …

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A common variant that alters SUN1 degradation associates with hepatic steatosis and metabolic traits in multiple cohorts

Kapil K. Upadhyay, Xiaomeng Du, Yanhua Chen, Raymond Zhao et autres

Abstract Nonalcoholic fatty liver (NAFL) and nonalcoholic steatohepatitis (NASH) represent a genetically and phenotypically diverse entity with no approved therapy, making it imperative to define the spectrum of pathways contributing to its pathogenesis. Rare variants in genes encoding nuclear envelope proteins cause …

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210: A COMMON CODING VARIANT IN SUN1 ASSOCIATES WITH HEPATIC STEATOSIS AND METABOLIC DISEASE IN MULTIPLE COHORTS AND ENHANCES SUN1 PROTEASOMAL DEGRADATION

Kapil K. Upadhyay, Xiaomeng Du, LC Stetson, Yanhua Chen et autres