Xinqi Liu

A novel AR molecular glue degrader via bivalent engagement of the N-terminal domain and RNF213–UBE2J2 complex

Kunzhong Wu, Qiong Wu, Yongzhi Lu, Qi Yang et autres

Abstract Targeted protein degradation enables the elimination of disease-relevant proteins through induced proximity between E3 ligases and substrates. Current androgen receptor (AR) therapies act via the ligand-binding domain (LBD) but fail against constitutively active LBD mutants or splice variants such as AR-V7. …

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Development and validation of an interpretable model for pre-chemotherapy triage of fatigue–pain–sleep disturbance burden in lung cancer

Benxiang Zhu, Yi Luo, 席瑞起, Qian Qi et autres

cn (code pays fourni par la source)

Triple-Responsive Hydrogel Integrating Polyphenol-Metal Activity for Infected Diabetic Wound Therapy

Haibo Mu, Hua Liang, Liangliang Hu, Xinqi Liu et autres

Infected diabetic wounds remain a major clinical challenge owing to the complex pathological microenvironment characterized by persistent bacterial infection, excessive reactive oxygen species (ROS), prolonged inflammation, and impaired angiogenesis. Herein, we report a triple-responsive, injectable, adhesive, and self-healing hydrogel (RCGel) designed to …

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VAPB is a negative regulator of STING-mediated innate immune signaling

Wangsheng Ji, Zhang Yin, Lianfei Zhang, Shui‐Lin Niu et autres

Stimulator of IFN genes (STING) is an endoplasmic reticulum (ER) signaling receptor involved in the type I interferon response to pathogen- or self-derived cytosolic double-stranded DNA. Excessive activation of STING is associated with many diseases, but the regulatory mechanism of STING activation …

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Waste-to-functional materials: Conductive networks in solid waste-based modified geopolymers enabled by alkali-mediated polycondensation

Xinqi Liu, Mengting Xu, Yanguang Wu

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Crustal stability monitoring and evaluation in the Sichuan-Yunnan region from GNSS

Xinqi Liu, Keke Xu, Jie Liu, Xiaoyi Wang et autres

Abstract The Sichuan-Yunnan region is located on the southeastern edge of the Tibetan Plateau. The region has long been characterized by frequent and intense seismic activity. Small and medium-sized earthquakes are found almost everywhere in the region, making it one of the …

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Phafin2 modulates the aggregation of NLRP3 on dispersed trans-Golgi network

Yong-meng Li, Chunsheng Chen, Yi-Long Lung Cancer Wu, Shuai Cheng Li et autres

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T-S Fuzzy Based Model Predictive Control Method for the Direct Yaw Moment Control System Design

Faan Wang, Xinqi Liu, Guodong Yin, Liwei Xu et autres

Abstract Distributed drive electric vehicles (DDEVs) endow the ability to improve vehicle stability performance through direct yaw-moment control (DYC). However, the nonlinear characteristics pose a great challenge to vehicle dynamics control. For this purpose, this paper studies the DYC through the Takagi-Sugeno …

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A novel feedback loop: CELF1/circ-CELF1/BRPF3/KAT7 in cardiac fibrosis

Yuan Jiang, Bowen Zhang, Bo Zhang, Xinhua Song et autres

Cardiac fibrosis is characterized by an elevated amount of extracellular matrix (ECM) within the heart. However, the persistence of cardiac fibrosis ultimately diminishes contractility and precipitates cardiac dysfunction. Circular RNAs (circRNAs) are emerging as important regulators of cardiac fibrosis. Here, we elucidate …

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The crystal structure of bis(tetramethylammonium) (di-μ2-aqua)hexaaqua-dibarium(II)) decavanadate

Yushan Jiang, Xinqi Liu, Jun Yu, Yijun Liu et autres

Abstract C4H20O18V5BaN, orthorhombic, Pnnm, a = 16.2079(17) Å, b = 9.4181(7) Å, c = 12.4399(9) Å, V = 1898.9(3) Å3, Rgt (F) = 0.0538, wRref (F 2) = 0.0830, T = 298 K.

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Crustal stability and hazard assessment along the Xinjiang-Tibet Railway by GNSS and gravity data

Jie Liu, Sen Kong, Shuanggen Jin, Yunlong Zhang et autres

cn (code pays fourni par la source)

Pan-C2(n+1): A Theoretical Prediction for 2D Carbon Allotropes

Xinqi Liu, Ang Ma, Yanan Zhang, Zhijun Yi et autres

In this work, the two-dimensional (2D) periodic armchair nanoribbon (pan-C 2( n +1) ) systems have been proposed and investigated by using the density functional theory (DFT). The pan-C 2( n +1) systems can be easily obtained by in-plane rotating the carbon …

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