Akiko Sasaki

From diabetic foot to dementia: A neurovascular continuum linking systemic diabetic vasculopathy, cerebral small vessel disease, and glymphatic dysfunction

Yuriko Inoue, Tatsunori Oguchi, Akio Inoue, Mikako Tanaka et autres

Diabetes mellitus, particularly type 2 diabetes mellitus (T2DM), is increasingly recognized as a major risk factor for cognitive decline and dementia. Epidemiological studies consistently demonstrate that individuals with diabetes exhibit a significantly elevated risk of both vascular cognitive impairment and Alzheimer's disease …

jp (code pays fourni par la source)

Device-associated infection surveillance in Japan: 2025 annual report of the Japanese society for infection prevention and control

Retsu Fujita, Yaoko Takano, Haruyo Sakaki, Hitomi Kurosu et autres

jp (code pays fourni par la source)

Rapid exacerbation of bilateral hip osteoarthritis induced by immune checkpoint inhibitor therapy: A case report

Yuta Imamura, Yuya Takakubo, Hanqing Huang, Juji Ito et autres

Immune checkpoint inhibitors (ICIs) have revolutionised cancer therapy but are associated with immune-related adverse events, including musculoskeletal symptoms. We report a case of rapid exacerbation of bilateral hip osteoarthritis (OA) induced by nivolumab. A 56-year-old woman with a history of developmental hip …

jp, us (code pays fourni par la source)

Cronkhite–Canada Syndrome With Multiple Mesenteric Lymphadenopathy: A Case Report

Takashi Nishino, Chikamasa Ichita, Akiko Sasaki, Chihiro Sumida

Cronkhite-Canada syndrome (CCS) is a rare nonhereditary disorder characterized by multiple gastrointestinal polyps and ectodermal changes. The mortality rate can reach up to 50% in patients with delayed diagnosis or inadequate treatment. A 78-year-old Japanese woman presented with diarrhea as the primary …

jp (code pays fourni par la source)

Clinical Features of Invasive Gastric Cancer Developed After Helicobacter pylori Eradication During Regular Endoscopic Surveillance

Akiko Sasaki, Junko Fujisaki, Masaaki Kobayashi, Ken Namikawa et autres

OBJECTIVES: Gastric cancer (GC) may be diagnosed after Helicobacter pylori eradication, sometimes with submucosal invasion; however, its clinical features on regular endoscopic surveillance remain unclear. This study evaluated invasive GC's characteristics after H. pylori eradication during regular endoscopic surveillance by comparing them …

jp, us, de (code pays fourni par la source)

ROS‐Driven PKCζ Signaling as a Widely Involved Mechanism for Cancer Cell Motility and Metastasis

Yasushi Sato, Maki Tanaka, Naoko Kitamura, Naoko Araki et autres

The enhancement of cell motility by bioactive molecules such as growth factors, hormones, and tissue factors is pivotal in cancer invasion and metastasis. However, the molecular mechanisms underlying this enhancement remain incompletely understood. In this study, we demonstrate that hepatoblastoma HepG2 cell …

jp (code pays fourni par la source)

Inosine shapes PD-1 blockade responses and synergizes with dual PD-1/CTLA-4 immunotherapy to enhance antitumor immunity

Yoichiro Narikawa, Atsuo Kuramasu, Masahiro Hosonuma, Masakazu Murayama et autres

Inosine, a bacterial metabolite and agonist of the adenosine A2A receptor, modulates antitumor immunity. However, its precise effects on immune checkpoint inhibitors remain unclear. This study aimed to evaluate the impact of inosine on the efficacy of anti-programmed cell death protein 1 …

jp, us (code pays fourni par la source)

Combination therapy with levofloxacin and the probiotic Clostridium butyricum MIYAIRI 588 enhances immune checkpoint inhibitor efficacy

Kohei Tajima, Masahiro Hosonuma, Eiji Funayama, Junya Isobe et autres

Abstract The gut microbiome influences immune checkpoint inhibitor (ICI) efficacy. In this study, we explored the effects of combined levofloxacin (LVFX) and Clostridium butyricum MIYAIRI 588 (CBM588) on ICI outcomes using a CT26 tumor model in BALB/c mice. When compared with the …

jp, us (code pays fourni par la source)

Probabilistic model of lightning initiation and propagation in thundercloud using a one-dimensional electric circuit

Emma Reyes, JL F Gabayno, R P Gammag, Nobuhiko Sarukura et autres

Abstract Lightning initiation and propagation is complex and probabilistic in nature. In this study, we attempt to replicate these phenomena using an electric circuit model. We reproduce lightning behaviors numerically by dividing an air column into discrete cells of resistor and capacitor …

ph, jp (code pays fourni par la source)

Combination therapy with cetirizine and anti-PD-1 antibody suppresses colitis-induced colon tumor formation in mice

Yuki Maruyama, Masahiro Hosonuma, Hitoshi Toyoda, Eiji Funayama et autres

jp (code pays fourni par la source)

Precision risk stratification of primary gastric cancer after eradication of H. pylori by a DNA methylation marker: a multicentre prospective study

Harumi Yamada, Seiichiro Abe, Hadrien Charvat, Takayuki Ando et autres

Background Precision cancer risk stratification for gastric cancer is urgently needed for the growing number of healthy people after Helicobacter pylori eradication. The epimutation burden in non-malignant tissues has been associated with cancer risk in multiple cross-sectional studies. Objective To confirm the …

jp, us (code pays fourni par la source)

Risk of Colorectal Endoscopic Submucosal Dissection in Older Adults: A Nationwide Study in Japan

Chikamasa Ichita, Tadahiro Goto, Akiko Sasaki, Kiyohide Fushimi et autres

INTRODUCTION: To evaluate the risks of colorectal endoscopic submucosal dissection (ESD) in older adult patients, given the increasing number of ESD in an aging population. METHODS: We conducted a retrospective cohort study using the Japanese nationwide database from 2012 to 2023. Patients …

jp (code pays fourni par la source)