Dequan Wang

Efficacy and Safety of Pregabalin-Tizanidine vs Pregabalin in Patients with Fibromyalgia: Study Protocol for a Multicenter, Prospective, Randomized, Controlled, Open-Label, Blinded Endpoint Trial

Qiang Liu, 文传兵, Yue’e Dai, Teng Ma et autres

Background: The global prevalence of fibromyalgia (FM) in the general population is estimated to range from 2% to 4%. Pregabalin, a gamma-aminobutyric acid (GABA) analogue, is one of the most widely prescribed medications for FM. However, at therapeutic doses, its limited efficacy …

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Clinical Guideline for Non-Surgical Treatment of Osteonecrosis of the Femoral Head (2025 Edition)

Cheng Zhixiang, Ding Zheng, Wenhua Li, Dequan Wang et autres

Background: Osteonecrosis of the femoral head (ONFH) is a prevalent and refractory condition in orthopedic clinical practice. In recent years, an increasing number of patients have been diagnosed in the early stages of the disease. Consequently, traditional surgical interventions alone can no …

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Colorimetric Assessment of Husked Grain Variation and Porridge Quality in Foxtail Millet

Gaolei Shi, Xiaolei Zhang, Dequan Wang, Feng Wang et autres

ABSTRACT Grain colour and porridge quality are crucial selection criteria in foxtail millet ( Setaria italica ) breeding. However, large‐scale phenotyping is a major constraint due to its reliance on slow and subjective manual evaluation, which significantly limits breeding efficiency. In this …

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From Natural Discovery to AI‐Guided Design: A Curated Collection of Compact Enhancers for Crop Engineering

Qi Yao, Jin Gao, Keling Wang, Yufeng Liu et autres

Precise transgene-free gene upregulation remains a challenge in crop biotechnology, as conventional enhancers often exceed CRISPR-mediated knock-in size constraints and face regulatory hurdles. Here we establish a foundational cross-species resource of compact transcriptional enhancers developed via STEM-seq, a high-throughput screening platform that …

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LIMI: Less is More for Agency

Xiao Yang, Jie L. Sun, Keyu Li, Ji Zeng et autres

We define Agency as the emergent capacity of AI systems to function as autonomous agents actively discovering problems, formulating hypotheses, and executing solutions through self-directed engagement with environments and tools. This fundamental capability marks the dawn of the Age of AI Agency, …

Gnetupendin A attenuates ischemic stroke injury by modulating oxidative stress through AMPK/SIRT1 pathway

Dequan Wang, Danyang Mu, Yan Mi, Guijie Zhang et autres

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A Chinese Guideline for the Diagnosis and Treatment of Chronic Cancer-related Pain

Zhixiang Cheng, Ke Ma, Wang Jianxiu, Dequan Wang et autres

Background: Chronic cancer-related pain can seriously damage physical and mental health of cancer patients. Eliminating cancer pain is basic right of cancer patients, controlling and eliminating cancer pain is the responsibility of medical staff. Objective: To further enhance the diagnosis and treatment …

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1,8-Cineole Alleviates Hippocampal Oxidative Stress in CUMS Mice via the PI3K/Akt/Nrf2 Pathway

Wenze Wu, Dequan Wang, Yuzhu Shi, Yichen Wang et autres

Background: This study investigates the neuroprotective effects of 1,8-cineole (1,8-CH), against hippocampal oxidative stress in a chronic unpredictable mild stress (CUMS) mice model of depression, focusing on the underlying molecular mechanisms. Methods: The effects of CUMS exposure were assessed by measuring oxidative …

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MedForge: Building Medical Foundation Models Like Open Source Software Development

Zheling Tan, Kexin Ding, Jin Gang Gao, Mu Zhou et autres

Foundational models (FMs) have made significant strides in the healthcare domain. Yet the data silo challenge and privacy concern remain in healthcare systems, hindering safe medical data sharing and collaborative model development among institutions. The collection and curation of scalable clinical datasets …

miR-1247-3p regulation of CCND1 affects chemoresistance in colorectal cancer

Dequan Wang, Jielian Wang, Fei Yao, Zhufu Xie et autres

The effectiveness of chemotherapy involving 5-fluorouracil and cisplatin (DDP) for the treatment of colorectal cancer (CRC) is often limited due to the emergence of drug resistance. An increasing body of research highlights the crucial role of abnormally expressed microRNAs (miR/miRNAs) in fostering …

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Ethanol extracts of Cinnamomum migao H.W. Li attenuates neuroinflammation in cerebral ischemia-reperfusion injury via regulating TLR4-PI3K-Akt-NF-κB pathways

Wenze Wu, Libin Xu, Danyang Mu, Dequan Wang et autres

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Editorial for Special Issue on Foundation Models for Medical Image Analysis

Xiaosong Wang, Dequan Wang, Xiaoxiao Li, Jens Rittscher et autres

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