Xiao He

ACACA modulates R-loop homeostasis to enhance lipid metabolism and microenvironmental interactions in ccRCC

Dong Zhang, Xinglin Chen, Xiao He, Minghao Deng et autres

R-loops are dynamic nucleic acid structures implicated in genome regulation and instability, yet their contributions to the tumor microenvironment (TME) of clear cell renal cell carcinoma (ccRCC) remain unclear. Here, we integrated publicly available ccRCC transcriptomic and clinical datasets to quantify R-loop-associated …

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Multi-omics and machine learning framework reveals ABCG2 as a therapeutic target of Eleven Flavored Shenqi Tablets in clear cell renal cell carcinoma

Dong Zhang, Xinglin Chen, Xiao He, Minghao Deng et autres

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Microglial Feimin Alleviates Cognitive Impairment in High‐Fat Diet‐Fed Mice

Ran Gao, Zhonghua Xiong, Wenting Su, Jiahui Deng et autres

Abstract Lipid droplet accumulation in microglia, microglia‐mediated neuroinflammation, and subsequent neuronal damage are hallmark features of high‐fat diet (HFD)‐induced cognitive impairment. In this analysis, this is proposed that a new molecule feimin (B230219D22Rik in mice) is a key negative regulator of LD …

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Recanalization for Symptomatic Non-acute Intracranial Large Vessel Occlusion: An Observational Study

Weili Li, Jun Zhang, Li-tang Han, Hongmei Niu et autres

AIM: This study investigated the efficacy and safety of endovascular revascularization for symptomatic non-acute atherosclerotic intracranial LVO. METHODS: For non-acute atherosclerotic intracranial large vessel occlusion (LVO), despite aggressive medical treatment, recurrent ischemic stroke or transient ischemic attack related to the occluded artery …

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Fullerenols as efficient ferroptosis inhibitor by targeting lipid peroxidation for preventing drug-induced acute kidney injury

Wei Chen, Bing Wang, Shanshan Liang, Lingna Zheng et autres

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Integrated serum pharmacochemistry, 16S rDNA sequencing, and metabolomics to reveal the material basis and mechanism of Shouhui Tongbian capsule against diphenoxylate-induced slow transit constipation in rats

Jiaying Yang, Xiao He, Jingchun Yao, Pin Zhang et autres

BACKGROUND: Slow transit constipation (STC) is highly prevalent and has rising incidence. Shouhui Tongbian capsule (SHTB) is a traditional Chinese Medicine formula with extensive and highly efficacious usage in STC treatment, however, its mechanism of action, especially the regulation of microbiome and …

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Development of human lactate dehydrogenase a inhibitors: high-throughput screening, molecular dynamics simulation and enzyme activity assay

Yuanyuan Shu, Jianda Yue, Yaqi Li, Yekui Yin et autres

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Gustative Roussy Immune Score is a Predictor for Major Pathological Response in Rectal Cancer: A Result from the Preoperative Intraarterial Chemoembolization Combined with Radiotherapy (PCAR) Study

Weina Yang, Xuemei Li, Chaofan Li, Chuan Chen et autres

Despite the emergence of various treatment strategies for rectal cancer based on neoadjuvant chemoradiotherapy, there is currently a lack of reliable biomarkers to determine which patients will respond well to neoadjuvant chemoradiotherapy. Through collecting hematological and biochemical parameters data of patients prior …

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Corrigendum to “Functional characterization of AF-04, an afucosylated anti-MARV GP antibody” [BBA Mol. Basis Dis. 1870 (2024) 166964]

Min Zhang, Yuting Zhang, Haiyan Wu, Xinwei Wang et autres

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Characterisation of an anticomplement polysaccharide BP-S1 from seeds of Brucea javanica

Xiao He, Ting Tan, Shilin Yang, Yulin Feng et autres

Bioactivity-guided purification obtained polysaccharide BP-S1 from seeds of Brucea javanica. The results showed that BP-S1 was a homogenous polysaccharide with molecular weight of 45.7 kDa, mainly composed of arabinose and glucose in the ratio of 1.0:1.0 and the backbone of BP-S1 was …

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Principles of Diagnosis and Treatment of Pheochromocytoma and Retroperitoneal Paraganglioma

Han Zhong Li, Jian Hua Deng, Wen Jin, Xiao He et autres

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Estimation of Marine Carbon Sink Capacity and Analysis of Influencing Factors in Guangdong Province

Feifei Chu, Xiao He, Jing Chang

China is a firm practitioner of the goal of "carbon peak" and "carbon neutrality", and the ocean, as the largest active carbon pool on the earth, plays a vital role in China's "dual-carbon" strategy. As an important part of the Guangdong-Hong Kong-Macao …

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