Weina Yang

Artificial intelligence-driven assessment of sarcopenia in orthopedic geriatrics: technical progress and clinical implications

Tengbo Pei, Yutian Lei, Yufang Gao, Minjie Zhang et autres

Sarcopenia, a progressive skeletal muscle disorder characterized by the loss of muscle mass and function, represents a significant challenge in geriatric orthopedics, with prevalence reaching as high as 48.7% in surgical populations. It is strongly associated with increased risks of falls, secondary …

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Insulin-like growth factor-1 enhances β-amyloid protein clearance in HMC3 microglia via low-density lipoprotein receptor-related protein 1-mediated pathway

Hongsong Guo, Xiaoqian Peng, Xiao Chen Zhang, John Bosco Ruganzu et autres

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Tanshinone IIA Promotes Hippocampal Neurogenesis in ApoE−/− Mice Through cAMP/PKA/CREB/BDNF Signaling Pathway

Zikang Yang, Xiaoqian Peng, Xiao Zhang, Hongsong Guo et autres

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TREM2 Alleviates Neuroinflammation and Improves Neurogenesis in ApoE−/− Mice by Regulating M1/M2 Microglial Polarization

Xiaoqian Peng, Zikang Yang, Xiangyuan Wu, John Bosco Ruganzu et autres

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Retrospective comparative study on efficacy and safety of different surgical procedures for pelvic organ prolapse

Yuquan Wang, Xi Guo, Weina Yang, Dong Liu et autres

The aim of this retrospective study was to analyze the efficacy and safety of lateral abdominal wall suspension during surgery compared with traditional procedures in patients with pelvic organ prolapse without uterine preservation. Collect the data of patients with uterine and vaginal …

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TREM2 promotes hippocampal neurogenesis through regulating microglial M2 polarization in APP/PS1 mice

Xiaoqian Peng, Xiao Zhang, Xiangyuan Wu, John Bosco Ruganzu et autres

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Retraction notice to “5-HT1AR alleviates Aß-induced cognitive decline and neuroinflammation through crosstalk with NF- B pathway in mice” [Int. Immunopharmacol. 82 (2020) 106354]

Meng Wang, Hang-Fan Zong, Ke-Wei Chang, Hua Han et autres

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Transcatheter rectal arterial chemoembolization with oxaliplatin and concurrent chemoradiotherapy in patients with locally advanced rectal cancer: A retrospective comparative study

Weina Yang, Chaofan Li, Jiamin Luo, Yan Feng et autres

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First in human intraarterial delivery of tislelizumab for the treatment of pMMR locally advanced rectal cancer: A single-arm, open label, phase II clinical trial

Weina Yang, Chengyuan Qian, Jiamin Luo, Chuan Chen et autres

• The possibility of immune checkpoint inhibitors combined with neoadjuvant chemoradiotherapy has been explored in multiple phase II clinical trials and reported promising pCR rates. However, severe immune-related toxicities have been a significant concern. Therefore, there is a pressing need for novel …

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Gustative Roussy Immune Score is a Predictor for Major Pathological Response in Rectal Cancer: A Result from the Preoperative Intraarterial Chemoembolization Combined with Radiotherapy (PCAR) Study

Weina Yang, Xuemei Li, Chaofan Li, Chuan Chen et autres

Despite the emergence of various treatment strategies for rectal cancer based on neoadjuvant chemoradiotherapy, there is currently a lack of reliable biomarkers to determine which patients will respond well to neoadjuvant chemoradiotherapy. Through collecting hematological and biochemical parameters data of patients prior …

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Negative prognostic impact of Co-mutations in TGFβ and TP53 pathways in surgically resected rectal tumors following neoadjuvant chemoradiotherapy

Chengyuan Qian, Weina Yang, Mengxia Li, Yan Feng et autres

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A novel neoadjuvant regimen of chemo-immuno-embolization with transcatheter rectal arterial intervention in locally advanced rectal cancer: a study protocol for a phase II trial (CIETAI-R)

Weina Yang, Chengyuan Qian, Mengxia Li, Chuan Chen et autres

Abstract Background Recent evidence suggests that patients with mismatch repair-deficient/microsatellite instability-high LARC are exceptionally sensitive to immune checkpoint inhibitors (ICIs), However, the majority of LARC patients are microsatellite-stable. Therefore, there is an urgent need to enhance the effectiveness of ICIs in this …

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