Jiang Ouyang

Spatiotemporal-switchable 2D NIR-II single-atom nanozyme for single-cell–level surgical navigation and glioblastoma phototherapy

Ping Shangguan, Yong Zhong, Haigang Wu, Yisheng Liu et autres

Single-cell–level resolution tumor therapy represents an advanced strategy against glioblastoma but lacks suitable theranostic agents. Here, we developed a spatiotemporal-switchable, two-dimensional (2D), bismuthene-based second near-infrared window (NIR-II) nanozyme. In this platform, the bismuthene scaffold simultaneously directed the assembly of indocyanine green (ICG) …

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Lipid Droplet‐Powered Microneedles Orchestrate Tumor Microenvironment Remodeling to Enhance Immune Activation in Melanoma

Somayeh Mahdinloo, Ping‐An Zhang, Qiuyu Zhang, Mulan Deng et autres

ABSTRACT Melanoma progression is sustained by profound metabolic rewiring and immune suppression within the tumor microenvironment, where adipocyte‐derived lipid droplets (LDs) serve as key metabolic regulators. Here, we exploit this intrinsic biology by engineering resveratrol‐loaded LDs (RSV‐LDs) as natural, lipophilic nanocarriers to …

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Design of bismuth polydopamine particle embedded, 3D-printed polycaprolactone scaffolds for antibacterial and immunoregulatory modulation of the peri-implant microenvironment

Ruoxue Dai, Muyuan Song, Xuan Liao, Lizhao Cai et autres

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Modular peptide nanofibres that self-assemble on bacterial membranes overcome antimicrobial resistance

Ziao Zhou, Dinghao Chen, Jiang Ouyang, Nan Kong et autres

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A Tumor‐Targeted tRF Therapeutics Triggers Ovarian Cancer Ferroptosis via Dual Inhibition of System Xc −

Jiang Ouyang, Jielin Wang, Haiying Wang, Na Tao et autres

ABSTRACT The severe chemoresistance‐caused high recurrence has made ovarian cancer (OVCA) the most lethal gynecological malignancy in clinical practice. Ferroptosis represents a promising therapeutic approach for OVCA, which could effectively overcome tumor resistance. Nevertheless, the traditional ferroptosis inducers lack specificity and selectivity, …

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Sprayable Lactococcus lactis -Nanocatalyst Gel for Postsurgical Immunomodulation in Preclinical Oral Squamous Cell Carcinoma

Senfeng Zhao, B. Liu, Yesi Shi, Zhuoming Zhou et autres

Oral squamous cell carcinoma (OSCC) is one of the most prevalent and aggressive head and neck cancers. Emerging evidence shows that distinct microbiomes coexist with tumor and immune cells in the tumor microenvironment (TME), shaping tumor progression and antitumor immunity. Harnessing probiotic-based …

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Engineered probiotics remodel tumor immune micro-environment for enhanced breast cancer metastasis inhibition and checkpoint inhibitor treatment

Mulan Deng, Zhaoyu Sun, Xindan Zhang, Qiuyu Zhang et autres

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A dual-functional injectable polysaccharide hydrogel incorporating oxygen-carrying nanoemulsion and VEGF for enhancing islet survival and glycemic control in diabetic mice

Yuwei Zhang, Zhaoyu Sun, Miao Liu, Jinxin Pang et autres

Abstract Type 1 diabetes (T1D) arises from autoimmune destruction of pancreatic β-cells, leading to lifelong dependence on exogenous insulin. Clinical islet transplantation offers a potential cure by restoring endogenous insulin secretion; however, its success is critically limited by poor post-transplant vascularization and …

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A Readily Synthesized All‐In‐One Nanowire Hydrogel: Toward Inhibiting Tumor Recurrence and Postoperative Infection

Tao Na, Buqing Sai, Ran Wei, Jielin Wang et autres

Abstract Surgical resection remains the frontline intervention for cancer; however, postoperative tumor recurrence and wound infection remain critical unmet challenge in surgical oncology. Herein, an all‐in‐one nanowired hydrogel (V‐Hydrogel) is developed through a facile one‐step assembly employing enzyme‐mimetic V 2 O 5 …

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Endogenous nanoplatforms for tumor photoimmunotherapy: Hypoxia modulation and STING pathway activation

Yongqing Yang, Ni Shao, Qiao Luo, Nianlan Cheng et autres

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Oral Delivery Strategies for Biological Drugs

Huiling Zeng, Mingyang Ma, Xiuju Peng, Yangyang Xie et autres

Biologics have low toxicity and are highly specific and biocompatible, offering advantages over small-molecule drugs. The administration of biologics in oral form provides a significant benefit in improving patient compliance. However, oral administration faces the challenge of a harsh gastrointestinal environment, including …

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Dual‐Responsive Multi‐Functional Silica Nanoparticles With Repaired Mitochondrial Functions for Efficient Alleviation of Spinal Cord Injury

Gui‐Bin Gao, Juanjuan Li, Yanming Ma, Min Xie et autres

ABSTRACT Preserved/rescued mitochondrial functions have a significant effect on maintaining neurogenesis, axonal carriage, and synaptic plasticity following spinal cord injury (SCI). We fabricated an ingenious redox‐responsive strategy for commanded liberation of NADH (reduced form of nicotinamide‐adenine dinucleotide) by bioactive diselenide‐containing biodegradable mesoporous …

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