Mulan Deng

Lipid Droplet‐Powered Microneedles Orchestrate Tumor Microenvironment Remodeling to Enhance Immune Activation in Melanoma

Somayeh Mahdinloo, Ping‐An Zhang, Qiuyu Zhang, Mulan Deng et autres

ABSTRACT Melanoma progression is sustained by profound metabolic rewiring and immune suppression within the tumor microenvironment, where adipocyte‐derived lipid droplets (LDs) serve as key metabolic regulators. Here, we exploit this intrinsic biology by engineering resveratrol‐loaded LDs (RSV‐LDs) as natural, lipophilic nanocarriers to …

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Food-grade production of recombinant human serum albumin in Kluyveromyces lactis and evaluation of its biological activity

Zhicheng Liang, Mulan Deng, Zhi Zhang, Xiuyi Liang et autres

Human serum albumin (HSA) is extensively used in clinical applications and cell culture media for many years. Traditional production of HSA from human blood is constrained by the availability of blood donations and the significant risk of viral transmission from donors. Kluyveromyces …

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Engineered probiotics remodel tumor immune micro-environment for enhanced breast cancer metastasis inhibition and checkpoint inhibitor treatment

Mulan Deng, Zhaoyu Sun, Xindan Zhang, Qiuyu Zhang et autres

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Reduced glycoprotein hormone β5 links male aging and testosterone decline to increased adiposity

Gengmiao Xiao, Aijun Qian, Zhuo Gao, Tingting Dai et autres

Aging commonly causes decline of testosterone or estrogen, leading to overaccumulation of fatness in men and women, respectively. Although such a phenomenon can be readily explained by estrogen's direct action on adipocytes in women, accumulative evidence does not support the direct action …

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Tetramethylpyrazine Targets HDAC6 ‐Mediated PINK1 Degradation to Alleviate Chronic Intermittent Hypoxia‐Induced Injury in Human Bronchial Epithelial Cells ( 16HBE )

Yanjie Chen, Hongye Chen, Zhixiong Huang, Mulan Deng et autres

Obstructive sleep apnea (OSA) is characterized by recurrent chronic intermittent hypoxia (CIH), which induces oxidative stress, inflammatory responses, and mitochondrial damage in bronchial epithelial cells. Tetramethylpyrazine (TMP) has been shown to exert lung-protective effects in other pathological models, but its role in …

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miR-1180–3p as a biomarker of obstructive sleep apnea hypopnea syndrome and its role in chronic intermittent hypoxia-induced vascular injury

Mulan Deng, Yanjie Chen, Hongye Chen, Qihui Chen

• miR-1180–3p is significantly overexpressed in the serum of patients with OSAHS. • miR-1180–3p acts as a potential diagnostic biomarker for OSAHS. • miR-1180–3p is an independent risk factor for the occurrence of OSAHS. • Downregulation of miR-1180–3p alleviates CIH-induced injury in …

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Systematic gene therapy derived from an investigative study of AAV2/8 vector gene therapy for Fabry disease

Mulan Deng, Hongyu Zhou, Shaomei He, Haoheng Qiu et autres

BACKGROUND: Fabry disease (FD) is a progressive multisystemic disease characterized by a lysosomal enzyme deficiency. A lack of α-galactosidase A (α-Gal A) activity results in the progressive systemic accumulation of its substrates, including globotriaosylceramide (Gb3) and globotriaosylsphingosine (Lyso-Gb3), which results in renal, …

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Development of Lanzyme as the Potential Enzyme Replacement Therapy Drug for Fabry Disease

Mulan Deng, Hongyu Zhou, Zhicheng Liang, Zhaoyang Li et autres

Fabry disease (FD) is a progressive multisystemic disease characterized by lysosomal enzyme deficiency. Enzyme replacement therapy (ERT) is one of the most significant advancements and breakthroughs in treating FD. However, limited resources and the high cost of ERT might prevent patients from …

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One-step construction of a food-grade expression system based on the URA3 gene in Kluyveromyces lactis

Zhicheng Liang, Mulan Deng, Zhi Zhang, Meirong Li et autres

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