Somayeh Mahdinloo

Lipid Droplet‐Powered Microneedles Orchestrate Tumor Microenvironment Remodeling to Enhance Immune Activation in Melanoma

Somayeh Mahdinloo, Ping‐An Zhang, Qiuyu Zhang, Mulan Deng et autres

ABSTRACT Melanoma progression is sustained by profound metabolic rewiring and immune suppression within the tumor microenvironment, where adipocyte‐derived lipid droplets (LDs) serve as key metabolic regulators. Here, we exploit this intrinsic biology by engineering resveratrol‐loaded LDs (RSV‐LDs) as natural, lipophilic nanocarriers to …

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Engineered probiotics remodel tumor immune micro-environment for enhanced breast cancer metastasis inhibition and checkpoint inhibitor treatment

Mulan Deng, Zhaoyu Sun, Xindan Zhang, Qiuyu Zhang et autres

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A Readily Synthesized All‐In‐One Nanowire Hydrogel: Toward Inhibiting Tumor Recurrence and Postoperative Infection

Tao Na, Buqing Sai, Ran Wei, Jielin Wang et autres

Abstract Surgical resection remains the frontline intervention for cancer; however, postoperative tumor recurrence and wound infection remain critical unmet challenge in surgical oncology. Herein, an all‐in‐one nanowired hydrogel (V‐Hydrogel) is developed through a facile one‐step assembly employing enzyme‐mimetic V 2 O 5 …

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A pH-responsive single-atom nanozyme for photothermal-augmented nanocatalytic tumor therapy

Na Tao, Shenghua Chen, Somayeh Mahdinloo, Qiuyu Zhang et autres

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An Update Review of Smart Nanotherapeutics and Liver Cancer: Opportunities and Challenges

Farid Mostafaei, Somayeh Mahdinloo, Hadi Valizadeh, Salar Hemmati et autres

Hepatocellular carcinoma (HCC) is the most common form of primary liver cancer, typically diagnosed in advanced stages. Chemotherapy is necessary for treating advanced liver cancer; however, several challenges affect its effectiveness. These challenges include low specificity, high dosage requirements, high systemic toxicity …

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Investigating the Effect of Basic Amino Acids and Glucosamine on the Solubility of Ibuprofen and Piroxicam

Hadi Valizadeh, Somayeh Mahdinloo, Negin Zakeri, Muhammad Sarfraz et autres

Purpose: Poor aqueous solubility hampers the development of several compounds as pharmacological agents. Hence, preparing novel formulations with augmented absorption is a challenge in pharmaceutical industries. In this paper, we have examined the effect of basic amino acids including arginine (ARG), lysine …

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Advances in Aptamers-Based Applications in Breast Cancer: Drug Delivery, Therapeutics, and Diagnostics

Tooba Gholikhani, Shalen Kumar, Hadi Valizadeh, Somayeh Mahdinloo et autres

Aptamers are synthetic single-stranded oligonucleotides (such as RNA and DNA) evolved in vitro using Systematic Evolution of Ligands through Exponential enrichment (SELEX) techniques. Aptamers are evolved to have high affinity and specificity to targets; hence, they have a great potential for use …

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Synthesis and preparation of vitamin A coupled butein-loaded solid lipid nanoparticles for liver fibrosis therapy in rats

Somayeh Mahdinloo, Salar Hemmati, Hadi Valizadeh, Mohammad Mahmoudian et autres

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Transferrin receptor-mediated liposomal drug delivery: recent trends in targeted therapy of cancer

Solmaz Mojarad-Jabali, Somayeh Mahdinloo, Masoud Farshbaf, Muhammad Sarfraz et autres

INTRODUCTION: Compared to normal cells, malignant cancer cells require more iron for their growth and rapid proliferation, which can be supplied by a high expression level of transferrin receptor (TfR). It is well known that the expression of TfR on the tumor …

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Drug delivery of pH-Sensitive nanoparticles into the liver cancer cells

Maryam Saadat, Farid Mostafaei, Somayeh Mahdinloo, Mahdieh Abdi et autres

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Efficient drug and gene delivery to liver fibrosis: rationale, recent advances, and perspectives

Somayeh Mahdinloo, Seyed Hossein Kiaie, Ala Amiri, Salar Hemmati et autres

Liver fibrosis results from chronic damages together with an accumulation of extracellular matrix, and no specific medical therapy is approved for that until now. Due to liver metabolic capacity for drugs, the fragility of drugs, and the presence of insurmountable physiological obstacles …

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