Jian Fei Cheng

Transcriptomic Analysis Reveals Opposing Roles of CEL1B in Sophorose- and Lactose-Induced Cellulase Expression in Trichoderma reesei Rut C30

Lu Wang, Junping Fan, Xiao He, Jian Fei Cheng et autres

The β-glucosidase CEL1B has been linked to regulating cellulase expression in Trichoderma reesei, yet its inducer-specific functions and broader regulatory roles remain poorly characterized. In this study, CRISPR-Cas9-mediated gene knockout was applied in the industrial high-producing T. reesei Rut C30 to investigate …

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Functional characterization of CEL3C reveals its critical role in regulating cellulase gene expression in Trichoderma reesei Rut C30

Lu Wang, Xiao He, Tian Tian, Jian Fei Cheng et autres

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Engineering thermotolerant microbial strains via TrRCC1 overexpression for efficient bioethanol production

Tingting Chen, Xiao He, Xinyan Zhang, Tian Tian et autres

Efficient conversion of corn stover to bioethanol via simultaneous saccharification and fermentation (SSF) is a promising strategy for sustainable biofuel production. A major current barrier to this process is the limited thermotolerance of Saccharomyces cerevisiae , which hampers its performance under the …

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Phased high-quality genome of the gymnosperm Himalayan Yew assists in paclitaxel pathway exploration

Zhenzhu Li, Hang Zong, Xiaonan Liu, Shimeng Liu et autres

BACKGROUND: Taxus wallichiana is an important species for paclitaxel production. Previous genome versions for Taxus spp. have been limited by extensive gaps, hindering the complete annotation and mining of paclitaxel (known as Taxol commercially) synthesis pathway-related genes. RESULTS: Here, we present the …

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Characterization of a small non-coding RNA S612 in Bacillus subtilis

Anqi Peng, Weijiao Zhang, Haibo Xiong, Luyao Zhang et autres

, some of which are involved in cell membrane integrity, cell wall synthesis, and sporulation initiation. Therefore, we propose that S612 is an important post-transcriptional regulator of cell morphology and sporulation.

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miR-26a/30d/152 are reliable reference genes for miRNA quantification in skin wound age estimation

Long-Long Suo, Jian Fei Cheng, Hao-Miao Yuan, Zhenfei Jiang et autres

MicroRNAs (miRNAs) are a class of small non-coding RNAs that exert their biological functions as negative regulators of gene expression. They are involved in the skin wound healing process with a dynamic expression pattern and can therefore potentially serve as biomarkers for …

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Unique bacterial communities associated with components of an artificial aquarium ecosystem and their possible contributions to nutrient cycling in this microecosystem

Jun Shi Zhou, Jian Fei Cheng, Xue Dong Li, Yan Hong Li

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The Addition of Epistatic Genetic Effects Increases Genomic Prediction Accuracy for Reproduction and Production Traits in Duroc Pigs Using Genomic Models

Jian Fei Cheng, Francesco Tiezzi, Jeremy Howard, Christian Maltecca et autres

Abstract Background: Genomic selection has been implemented in livestock genetic evaluations for years. However, currently most genomic selection models only consider the additive effects associated with SNP markers and nonadditive genetic effects have been for the most part ignored. Methods: Production traits …

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Application Prospect of MicroRNA in Skin Wound Age Estimation.

Jian Fei Cheng, Long-Long Suo, Linlin Wang, Rui Zhao et autres

Wound age estimation is one of the major tasks in forensic practice. However, relatively accurate estimation of the wound age is still a conundrum and research spotlight world-widely. Studies show that microRNAs (miRNAs) are involved in the whole process of the skin …

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Novel GALC Mutations Cause Adult-Onset Krabbe Disease With Myelopathy in Two Chinese Families: Case Reports and Literature Review

Junfei Zhong, Fei Jiang, Huan Yang, Jing Li et autres

Krabbe disease (KD), also referred to as globoid cell leukodystrophy, is a rare autosomal recessive lysosomal storage disorder caused by β-galactocerebrosidase (GALC) deficiency. Most patients affected by this disease are infants; less than 10% of cases suffer from adult-onset KD. In this …

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Study on the Administration Method of Combining Tetrandrine with Adriamycin to Reverse Drug-Resistance of Leukemia

Baoan Chen, Fang Zhou, Jian Fei Cheng, Huihui Song et autres

Increasing drug efflux pumps (P-gp) on the cell membrane due to the overexpression of MDR1 gene in tumor cells is the main mechanism of multidrug resistance of cancer cells. P-gp belongs to the ATP-binding cassette family and functions as a transmembrane efflux …

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Sequence analysis of mtDNA COI gene and molecular Phylogeny of Parasitic Unionicolid Mites (Acari: Unionicolidae: Unionicola) in China

Jian Fei Cheng, Xin Huang, Liangliang Huang, Chungen Wen

A nucleotide sequence analysis of cytochrome oxidase I (COI) gene fragment from parasitic unionicolid mites is performed in this paper. The aligned nucleotide fragment is 664bp (including gaps) in length, including 374 conserved sites, 284 variable sites, 73 conversion sites, 51 transpose …

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