Luyao Zhang

In Situ Modulation of the Au-MoS2 Contact Barrier via Triboelectric Plasma-Assisted Electron Injection

Yang Liu, Haodi Wu, Junmeng Guo, Jiao Wang et autres

Abstract Two-dimensional (2D) van der Waals materials, especially transition-metal dichalcogenide molybdenum disulfide (MoS2), have emerged as key candidate materials for advancing optoelectronics and integrated circuits due to their unique physical properties. However, the high contact barrier between the metal and semiconductor has …

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Infrared stimulation of mitochondrial metabolism in deep-sea yeast expands the energetic framework of hydrothermal ecosystems

Jie Dai, Luyao Zhang, Yingshan Li, Rui Zhao et autres

Abstract Deep-sea hydrothermal vents are archetypal chemosynthetic ecosystems, yet the intense geothermal near-infrared (NIR) radiation emitted by black smoker chimneys remains a largely unexplored environmental factor. While infrared (IR)-driven photosynthesis has been described in vent-associated bacteria, whether deep-sea eukaryotes can biologically respond …

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Lactobacillus fermentum ZNL16 attenuates ETEC-induced intestinal injury by regulating gut microbiota and short-chain fatty acid metabolism to suppress the IL-17/JAK2-STAT3 pathway

Yihan Dong, Yushan Xie, Y.T. Mai, Luyao Zhang et autres

Enterotoxigenic Escherichia coli (ETEC) is a major cause of diarrhea, threatening neonates, travelers, and livestock by disrupting the intestinal barrier and weakening immunity. Lactobacillus fermentum has been shown to enhance barrier integrity and modulate immune activity, while gut microbiota and their metabolites …

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Transmembrane BAX inhibitor motif containing 1 inhibition of lysosomal degradation of TGF-β receptor 1 suppresses cellular senescence and hepatocarcinogenesis

Wei Yu, Yating Zheng, Xiaojuan Hou, Kuizhi Zhang et autres

Growing evidence indicates that the cellular senescence (CS) plays a crucial role in hepatocarcinogenesis. Transmembrane BCL-2-associated X protein inhibitor motif containing 1 (TMBIM1) has been shown to inhibit CS. However, the role and mechanism of TMBIM1 associated CS in hepatocarcinogenesis remains unclear. …

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WDFY2 promotes MRN complex formation required for homologous recombination-mediated DNA repair

Ya-Fei Lu, Huangqi Tang, Longjiang Di, Yerkezhan Yerkinkazhina et autres

The MRE11-RAD50-NBS1 (MRN) complex is fundamental for detecting and repairing DNA double-strand breaks (DSBs), thereby safeguarding genome integrity. However, the precise mechanism governing MRN complex recruitment to DSBs remains largely unexplored. Here, we identify WD40- and FYVE domain-containing protein 2 (WDFY2) as …

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Butterfly-inspired ultraviolet vision chip based on ZnO memristor arrays for real-time dynamic plant motion tracking

Yang Liu, Junmeng Guo, Jiao Wang, Yuwei Zhao et autres

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Astragaloside IV potentiates cisplatin sensitivity in triple-negative breast cancer via STING signaling pathway activation

Bufan Bai, Luyao Zhang, Yifei Zhang, Yi-Yu Lu et autres

• The efficacy of cisplatin in triple-negative breast cancer (TNBC) is limited by several critical challenges. Astragaloside IV synergistically enhances the therapeutic efficacy of cisplatin against TNBC while ameliorating its adverse effects. • Integrating bioinformatics analysis (WGCNA, LASSO, and CIBERSORT), transcriptomic and …

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Downregulation of Tra2α and Tra2β suppresses lipopolysaccharide-induced inflammation in macrophages by regulating MyD88 mRNA alternative splicing

Yu Fu, Luyao Zhang, Yanjing Wang, Bo Cheng et autres

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Pretreatment collateral circulation status modifies the effect of blood pressure trajectory on outcome after endovascular therapy

Zhenzhen Li, Linxiang Ji, Luyao Zhang, Shiyao Zhang et autres

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Triboelectric plasma regulated ZnO thin films for ultra-low power room-temperature acetone gas sensing

Yang Liu, Junmeng Guo, Jiao Wang, Yatao Zhang et autres

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Reversing the “cold” tumor microenvironment: the role of neoantigen vaccines in prostate cancer

Jiani Wang, Rui Guo, Luyao Zhang, Wen Zuo et autres

Prostate cancer (PCa) is a common malignancy with a “cold” tumor microenvironment (TME) that limits immunotherapy efficacy. Neoantigens from non-synonymous mutations are potential immunotherapeutic targets. We identified the neoantigens map in the RM-1 murine prostate cancer model by the whole exome sequencing. …

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Fine structural design of 3βHSD1 inhibitors for prostate cancer therapy

Dongyin He, Luyao Zhang, Leiye Yu, Y. N. Zhang et autres

Prostate cancer is a global health challenge, particularly for patients resistant to the second-generation anti-androgen receptor pathway inhibitors. The steroidogenic enzyme 3β-hydroxysteroid dehydrogenase type 1 (3βHSD1) has emerged as a promising therapeutic target and the corresponding inhibitors, biochanin-A (BCA) and its derivatives, …

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