Kang-Yun Sun

Exogenous NADPH exerts a positive inotropic effect and enhances energy metabolism via SIRT3 in pathological cardiac hypertrophy and heart failure

Ke Qian, Jie Tang, Yuejuan Ling, Ming Yue Zhou et autres

BACKGROUND: Therapies are urgently required to ameliorate pathological cardiac hypertrophy and enhance cardiac function in heart failure. Our preliminary experiments have demonstrated that exogenous NADPH exhibits a positive inotropic effect on isolated heart. This study aims to investigate the positive inotropic effects …

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hAECs and their exosomes improve cardiac function after acute myocardial infarction in rats

Yiqing Zhang, Hong Lu, Yufeng Jiang, Shengda Hu et autres

BACKGROUND: Human amniotic epithelial cells (hAECs) are seed cells used to treat acute myocardial infarction (AMI), but their mechanism remains unclear. METHODS: We cultured hAECs and extracted exosomes from culture supernatants. Next, we established a stable AMI model in rats and treated …

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Microvolt T-wave alternans complemented with electrophysiologic study for prediction of ventricular tachyarrhythmias in patients with arrhythmogenic right ventricular cardiomyopathy

Sheliang Xue, Xiaofeng Hou, Kang-Yun Sun, Yao Wang et autres

BACKGROUND: The long-term predicted value of microvolt T-wave alternans (MTWA) for ventricular tachyarrhythmia in patients with arrhythmogenic right ventricular cardiomyopathy (ARVC) remains unclear. Our study explored the characteristics of MTWA and its prognostic value when combined with an electrophysiologic study (EPS) in …

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Expression of C2A domain of synaptotagmin I fusion protein and its imaging in the ischemia-reperfusion rat model

Kang-Yun Sun, Jundong Zhou, Fei Shen, Wei Fang et autres

Objective To evaluate myocardial apoptosis with 99Tcm-C2A-GST myocardial imaging using the recombined C2A domain of Synaptotagmin Ⅰ by gene engineering. Methods ( 1 ) The C2A gene was inserted into the prokaryotic glutathione S-transferate (GST) fusion protein expression plasmid pGEX-6P-1. The recombinant …

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Xiaoyujiangzhi capsule in prevention of hyperlipidemia and atherosclerosis in rabbits

Kang-Yun Sun

AIM To observe the preventive effect of Xiaoyujiangzhi capsule in primary hyperlipidemia and atherosclerotic development.METHODS Forty-eight New Zealand rabbits were divided into six groups: normal control,model of fed with high fat diet,treated with Xiaoyujiangzhi capsules at dose of 25 mg/kg,treated with Xiaoyujiangzhi …