Xiaoyujiangzhi capsule in prevention of hyperlipidemia and atherosclerosis in rabbits

Le résumé fourni par la source

AIM To observe the preventive effect of Xiaoyujiangzhi capsule in primary hyperlipidemia and atherosclerotic development.METHODS Forty-eight New Zealand rabbits were divided into six groups: normal control,model of fed with high fat diet,treated with Xiaoyujiangzhi capsules at dose of 25 mg/kg,treated with Xiaoyujiangzhi capsules at dose of 50 mg/kg,treated with Xiaoyujiangzhi capsules at dose of 100 mg/kg,treated with Xue zhikang capsules at dose of 65 mg/kg.All the rabbits,except those in normal control,were fed with high-fat diet(containing cholesterol 150 mg/kg and lard 0.5 ml/kg) and were treated respectively with Xiaoyujiangzhi capsules and Xuezhikang capsules for 28 days.At the end of 28 days,the lipidemia levels were measured and the animals were killed.Pathological examination was conducted in big artery specimens of the animals.RESULTS Serum total cholesterol(TC) [(1.91±(0.94)),(1.55±0.50),(1.32±0.34)mmol/L] and low density cholesterol(LDL-C) [(1.03±(0.79)),(0.72±0.58),(0.59±0.27)mmol/L] levels were far lower in all the groups treated with Xiaoyujiangzhi capsule than those in model of fed with high fat diet [(5.64±1.60),(4.29±1.55)mmol/L,P0.01].Serum triglyceride(TG) had a declining tendency in all the groups treated with Xiaoyujiangzhi capsule,with a statistical declining difference in the large-dose group [((0.93)±0.44),(1.65±0.69) mmol/L,P0.05].Pathological examination in large artery specimen showed that the lipid sediment in artery wall decreased in all the groups treated with Xiaoyujiangzhi capsule,particularly in the large-dose group.CONCLUSION Xiaoyujiangzhi capsule has effects of preventing hyperlipidemia and atherosclerotic development.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.