2024
article
OpenAlex
Bao‐Chun Jiang, Yuejuan Ling, Jun Gu, Xiaobo Wu et autres
Neuropathic pain is a debilitating chronic condition that lacks effective treatment. The role of cytokine- and chemokine-mediated neuroinflammation in its pathogenesis has been well documented. Follistatin (FST) is a secreted protein known to antagonize the biological activity of cytokines in the transforming …
cn, us
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Accès ouvert
2024
article
OpenAlex
Song Deng, Dekang Nie, Yue Huang, Yu Yang et autres
Glioblastoma multiforme (GBM) is among the most challenging malignant brain tumors, making the development of new treatment strategies highly necessary. Glioma stem cells (GSCs) markedly contribute to drug resistance, radiation resistance, and tumor recurrence in GBM. The therapeutic potential of nanomaterials targeting …
cn, kr
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Accès ouvert
2023
article
OpenAlex
Ke Qian, Jie Tang, Yuejuan Ling, Ming Yue Zhou et autres
BACKGROUND: Therapies are urgently required to ameliorate pathological cardiac hypertrophy and enhance cardiac function in heart failure. Our preliminary experiments have demonstrated that exogenous NADPH exhibits a positive inotropic effect on isolated heart. This study aims to investigate the positive inotropic effects …
cn
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Accès ouvert
2023
article
OpenAlex
Yu-Sheng Yang, Qianqian Liu, Song Deng, Qian Shao et autres
Abstract Aims The current evidence demonstrates that mesenchymal stem cells (MSCs) hold therapeutic potential for ischemic stroke. However, it remains unclear how changes in the secretion of MSC cytokines following the overexpression of heme oxygenase‐1 (HO‐1) impact excessive inflammatory activation in a …
cn
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2023
article
OpenAlex
Dekang Nie, Yuejuan Ling, Wenxin Lv, Qianqian Liu et autres
application that simultaneously serves as photothermal agent and induces immunogenic cell death after GBM surgical resection to enhance the antitumor immunity and delay tumor recurrence. The hemostatic matrix system (Surgiflo@PCN) contains Surgiflo, a multispace structure that can be used to penetrate different …
cn
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Accès ouvert
2023
article
OpenAlex
Yuejuan Ling, Dekang Nie, Yue Huang, Mengyuan Deng et autres
Abstract Chronic pain has attracted wide interest because it is a major obstacle affecting the quality of life. Consequently, safe, efficient, and low‐addictive drugs are highly desirable. Nanoparticles (NPs) with robust anti‐oxidative stress and anti‐inflammatory properties possess therapeutic possibilities for inflammatory pain. …
cn
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Accès ouvert
2022
article
OpenAlex
Yu Feng Zou, Xue‐Hui Bai, Lingchi Kong, Feifei Xu et autres
Histone lysine crotonylation (KCR), a novel epigenetic modification, is important in regulating a broad spectrum of biological processes and various diseases. However, whether KCR is involved in neuropathic pain remains to be elucidated. We found KCR occurs in macrophages, sensory neurons, and …
cn
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Accès ouvert
2020
article
OpenAlex
Yuejuan Ling, Tingyu Ding, Yong‐Jing Gao, Bao‐Chun Jiang
Background: Currently, medical treatment of inflammatory pain is limited by a lack of safe and effective therapies. Triptonide (TPN), a major component of Tripterygium wilfordii Hook.f . with low toxicity, has been shown to have good anti-inflammatory and neuroprotective effects. The present …
cn
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2020
article
OpenAlex
Christophe Gattlen, Alexandru‐Florian Deftu, Raquel Tonello, Yuejuan Ling et autres
Spinal microglia change their phenotype and proliferate after nerve injury, contributing to neuropathic pain. For the first time, we have characterized the electrophysiological properties of microglia and the potential role of microglial potassium channels in the spared nerve injury (SNI) model of …
ch, ro, us, cn
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Accès ouvert
2020
preprint
OpenAlex
Yuejuan Ling, Tingyu Ding, Yong‐Jing Gao, Bao‐Chun Jiang
Abstract Background: Triptonide (TPN) is a major component of Tripterygium wilfordii Hook.f., and reportedly has anti-inflammatory and neuroprotective effects. Recent studies have demonstrated that the phosphatidylinositol 3-kinase (PI3K)/AKT pathway plays an important role in the pathogenesis of inflammatory pain. Here we investigated …
cn
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Accès ouvert
2019
article
OpenAlex
Xiaojuan Liu, Raquel Tonello, Yuejuan Ling, Yong‐Jing Gao et autres
BACKGROUND: Paclitaxel is a widely used and potent chemotherapeutic agent for the treatment of cancer. However, patients receiving paclitaxel often develop an acute pain syndrome for which there are few treatment options. Astrocytes play an important role in the pathogenesis of pain …
cn, us
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