Accès ouvert
2026
preprint
OpenAlex
Sara Hussein Mahmoud, Nathaniel D. Jackson, Ramya S. Barre, Yao Ma et autres
Abstract Transgenic K18-hACE2 mice are a standard model for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), albeit with limitations. A mouse-adapted 30 (MA30) SARS-CoV-2 has been developed to allow infection of wild-type (WT) mice strains. However, SARS-CoV-2 MA30 cannot be easily tracked …
us, Égypte
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Accès ouvert
2026
article
OpenAlex
Yao Ma, Qiao Xu, Feng Sun, Xiaomin Wang et autres
The invasive vine Mikania micrantha H. B. K. poses severe threats to biodiversity and ecosystem stability in tropical and subtropical regions, calling for sustainable ecological approaches. This study explores how the native legume Pueraria lobata var. thomsonii Benth displaces M. micrantha in …
cn
(code pays fourni par la source)
Accès ouvert
2025
preprint
OpenAlex
Yao Ma, Chengjin Ye, Michael S. Piepenbrink, Sara Hussein Mahmoud et autres
ABSTRACT Neutralizing antibodies (NAbs) targeting the spike (S) glycoprotein remain a crucial therapeutic strategy against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, emerging viral variants have escaped all Food and Drug Administration (FDA)-approved NAb treatments, underscoring the urgent need for effective …
us, Égypte
(code pays fourni par la source)
Accès ouvert
2025
preprint
OpenAlex
Yao Ma, Chengjin Ye, R Rahisuddin, Sarah Ahmed Mohamed Mahmoud et autres
ABSTRACT Ensitrelvir is an antiviral drug that specifically targets the main protease (M pro ) of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has been approved for the treatment of coronavirus disease 2019 (COVID-19) due to the conservation of its target protein …
us, Égypte
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Xueyong Zhu, Ahmed Magdy Khalil, Michael S. Piepenbrink, Wenli Yu et autres
Monoclonal antibodies (mAbs) that recognize and inhibit a diverse range of influenza viruses, although relatively rare, have been isolated following infection or vaccination. Study of their ontology and mechanisms of action informs universal vaccine and therapeutic development. We have previously described a …
us
(code pays fourni par la source)
Accès ouvert
2025
preprint
OpenAlex
Xueyong Zhu, Ahmed Magdy Khalil, Michael S. Piepenbrink, Wenli Yu et autres
Monoclonal antibodies (mAbs) that recognize and inhibit a diverse range of influenza viruses, although relatively rare, have been isolated following infection or vaccination. Study of their ontology and mechanisms of action informs universal vaccine and therapeutic development. We have previously described a …
us, Égypte
(code pays fourni par la source)
Accès ouvert
2025
preprint
OpenAlex
Yao Ma, Chengjin Ye, Ahmed Magdy Khalil, Sara Hussein Mahmoud et autres
The emergence of SARS-CoV-2 variants has necessitated continuous updating of vaccines. In contrast, antivirals remained effective as they target conserved viral proteins that are essential for the viral life cycle. However, several mutations in SARS-CoV-2 that may affect the efficacy of United …
us, Égypte
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Siyu Wu, Lan Yao, Wenxiang Zhang, Pengde Chen et autres
Diabetic nephropathy (DN) is one of the major complications of diabetes mellitus. Pyroptosis is a type of programmed cell death that is closely related to the development of DN, however the molecular mechanism of pyroptosis in the development of DN is still …
cn
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Xiaofei Feng, Yao Ma, Yuhao Zhao, Zhenrui Zhao et autres
BACKGROUND: Osteoarthritis is a degenerative disease, and current drug treatment is to give nonsteroidal anti-inflammatory drugs to relieve symptoms. The anti-inflammatory ability of parecoxib and ilomastat has been confirmed, but the synergistic effect of combined administration in osteoarthritis has not been clear. …
cn
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Ramya S. Barre, Anna Allué‐Guardia, Ruby A. Escobedo, Vinay Shivanna et autres
The host range of HPAIV H5N1 was recently expanded to include ruminants, particularly dairy cattle in the United States (US). Shortly after, human H5N1 infection was reported in a dairy worker in Texas following exposure to infected cattle. Herein, we rescued the …
us, mn, Égypte
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Michael S. Piepenbrink, Ahmed Magdy Khalil, Ana C. Chang, Ahmed Mostafa et autres
SARS-CoV-2 continues to be a public health burden, driven in-part by its continued antigenic diversification and resulting emergence of new variants. By increasing herd immunity, current vaccines have improved infection outcomes for many. However, prophylactic and treatment interventions that are not compromised …
us, Égypte, mn
(code pays fourni par la source)
2024
preprint
OpenAlex
Ahmed Mostafa, Ramya S. Barre, Anna Allué‐Guardia, Ruby A. Escobedo et autres
Abstract The host range of HPAIV H5N1 was recently expanded to include ruminants, particularly dairy cattle in the United States. Shortly after, human H5N1 infection was reported in a dairy worker in Texas following exposure to infected cattle. Herein, we rescued the …
us
(code pays fourni par la source)