Accès ouvert
2026
article
OpenAlex
Kyra Woloszczuk, David Joyner, Jennifer Connors, Mariana Bernui et autres
Immune responses elicited by natural infection of the coronavirus SARS-CoV-2 (COVID-19) show significant heterogeneity in the magnitude and quality of memory T and B cell responses. However, little is known about the contributing factors. In this study, we investigated the early immune …
us, nl, ca
(code pays fourni par la source)
Accès ouvert
2026
article
OpenAlex
Naresh Doni Jayavelu, Hady Samaha, Sonia Tandon Wimalasena, Annmarie Hoch et autres
The post-acute sequelae of SARS-CoV-2 (PASC), also known as long COVID, remain a significant health issue that is incompletely understood. Predicting which acutely infected individuals will develop long COVID is challenging due to the absence of established biomarkers, clear disease mechanisms, or …
Égypte, us, ca
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Ana Carolina Monteiro, Harry C. Pickering, Aartik A. Sarma, Clove S. Taylor et autres
BACKGROUND: Elevated circulating endothelial cells (CECs), released from monolayers after insult, have been implicated in worse outcomes in ARDS and COVID-19, however there is no consensus proteomic phenotype that define CECs. We queried whether a transcriptomic approach would alternatively support the presence …
us
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Joann Diray‐Arce, Ana C. Chang, Sara Moradipoor, Donato Amodio et autres
The International Network of Special Immunization Services (INSIS) was established to investigate the causes and risk factors of rare adverse events following immunizations (AEFIs) and develop immunization strategies for mitigating or preventing risk for individuals with prior AEFIs or at risk of …
us, ca, it, au, Afrique du Sud, nz, in
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Harry C. Pickering, Joanna M. D. Schaenman, Hoang Van Phan, Cole P. Maguire et autres
Coronavirus disease 2019 (COVID-19) poses significant risks for solid organ transplant recipients, who have atypical but poorly characterized immune responses to infection. We aim to understand the host immunologic and microbial features of COVID-19 in transplant recipients by leveraging a prospective multicenter …
us
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Michael S. Piepenbrink, Ahmed Magdy Khalil, Ana C. Chang, Ahmed Mostafa et autres
SARS-CoV-2 continues to be a public health burden, driven in-part by its continued antigenic diversification and resulting emergence of new variants. By increasing herd immunity, current vaccines have improved infection outcomes for many. However, prophylactic and treatment interventions that are not compromised …
us, Égypte, mn
(code pays fourni par la source)
Accès ouvert
2024
preprint
OpenAlex
Michael S. Piepenbrink, Ahmed Magdy Khalil, Ana C. Chang, Ahmed Mostafa et autres
SARS-CoV-2 continues to be a public health burden, driven in-part by its continued antigenic diversification and resulting emergence of new variants. While increasing herd immunity, current vaccines, and therapeutics have improved outcomes for some; prophylactic and treatment interventions that are not compromised …
us, Égypte
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Hoang Van Phan, Alexandra Tsitsiklis, Cole P. Maguire, Elias K. Haddad et autres
Age is a major risk factor for severe coronavirus disease 2019 (COVID-19), yet the mechanisms behind this relationship have remained incompletely understood. To address this, we evaluated the impact of aging on host immune response in the blood and the upper airway, …
us
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Benjamin Samuel Haslund-Gourley, Kyra Woloszczuk, Jintong Hou, Jennifer R Connors et autres
The glycosylation of IgG plays a critical role during human severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, activating immune cells and inducing cytokine production. However, the role of IgM N-glycosylation has not been studied during human acute viral infection. The analysis …
us, ca
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Al Ozonoff, Naresh Doni Jayavelu, Shanshan Liu, Esther C. Melamed et autres
Post-acute sequelae of SARS-CoV-2 (PASC) is a significant public health concern. We describe Patient Reported Outcomes (PROs) on 590 participants prospectively assessed from hospital admission for COVID-19 through one year after discharge. Modeling identified 4 PRO clusters based on reported deficits (minimal, …
us, ca
(code pays fourni par la source)
Accès ouvert
2023
article
OpenAlex
Joann Diray‐Arce, Slim Fourati, Naresh Doni Jayavelu, Ravi Kumar Patel et autres
The IMPACC cohort, composed of >1,000 hospitalized COVID-19 participants, contains five illness trajectory groups (TGs) during acute infection (first 28 days), ranging from milder (TG1-3) to more severe disease course (TG4) and death (TG5). Here, we report deep immunophenotyping, profiling of >15,000 …
us
(code pays fourni par la source)
Accès ouvert
2022
article
OpenAlex
Al Ozonoff, Joanna M. D. Schaenman, Naresh Doni Jayavelu, Carly E. Milliren et autres
BACKGROUND: Better understanding of the association between characteristics of patients hospitalized with coronavirus disease 2019 (COVID-19) and outcome is needed to further improve upon patient management. METHODS: Immunophenotyping Assessment in a COVID-19 Cohort (IMPACC) is a prospective, observational study of 1164 patients …
us
(code pays fourni par la source)