Accès ouvert
2026
article
OpenAlex
Motoki Endo, Atsuhiko Yagishita, Kazuma Iimura, Aika Iijima et autres
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia and a major risk factor for stroke and heart failure. 1 Catheter ablation with pulmonary vein isolation (PVI) is an established rhythm-control strategy for drug-refractory paroxysmal AF. 2 Pulsed field ablation (PFA), …
jp
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Accès ouvert
2026
article
OpenAlex
A. Yokota, Wataru Munakata, Toru Kiguchi, Yoshiaki Ogawa et autres
Tagraxofusp (TAG), a first-in-class CD123-targeted therapy, is a recombinant fusion protein of human interleukin-3 conjugated to a truncated diphtheria toxin payload. Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is an aggressive orphan hematologic cancer with a poor prognosis, and is derived from plasmacytoid …
jp
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2025
article
OpenAlex
Kaito Harada, Shino Iwata, Shunsuke Tomita, Miina Nasukawa et autres
Cord blood transplantation (CBT) is an alternative donor option for patients lacking suitable matched donors, particularly in high-risk acute myeloid leukemia (AML) or myelodysplastic syndromes (MDS). We retrospectively analyzed 76 adults undergoing reduced-intensity conditioning allogeneic transplantation using one of five donor types: …
jp
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Accès ouvert
2025
article
OpenAlex
Lorenzo Falchi, Marcel Nijland, Huiqiang Huang, Kim Linton et autres
Background An unmet need persists for chemotherapy-free regimens that induce durable responses for relapsed or refractory follicular lymphoma. Lenalidomide and rituximab (R 2 ) is an accepted standard of care in this population. The EPCORE FL-1 trial aimed to evaluate the efficacy …
us, nl, cn, gb, au, br, gr, at, es, il, fr, it, nz, hu, cz, ar, kr, jp, dk
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Accès ouvert
2025
article
OpenAlex
Jun Takizawa, Isao Yoshida, Yoshiaki Ogawa, Tomomi Toubai et autres
The development of effective and safe therapies for chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL) in Japan remains a key focus of research. We conducted a phase 2, open-label, multicenter, non-comparative study to evaluate the safety and efficacy of fixed-duration venetoclax plus …
jp, us
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Accès ouvert
2025
article
OpenAlex
Yoshiaki Ogawa, Hisaki Aiba, Yohei Kawaguchi, Satoshi Yamada et autres
Reconstruction of the distal radius after en bloc bone tumor resection is challenging. Among various surgical reconstruction methods, ulnar translocation is a simple approach that does not require vascular anastomosis, autograft harvesting, or prosthesis preparation. This report describes the 7-year follow-up of …
jp
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2025
conference-abstract
OpenAlex
Naval Guastad Daver, Joshua F. Zeidner, Justin M. Watts, Junichiro Yuda et autres
Abstract Introduction: Enzomenib (ENZO, DSP-5336) is an investigational, oral small molecule inhibitor of the menin and KMT2A protein interaction, intentionally designed with different physiochemical properties such as short half-life of 2-5 hours, low lipophilicity and high clearance that may lead to differences …
us, jp, es, it, fr, ca, sg, tw, be
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Accès ouvert
2025
article
OpenAlex
Daisuke Ogiya, Rikio Suzuki, Shun Goto, Yosuke Nakagawa et autres
Recent advances in multiple myeloma (MM) treatment, including bispecific antibodies (BsAbs), have improved outcomes. Elranatamab, a BsAb targeting B-cell maturation antigen and CD3, has shown efficacy in relapsed/refractory MM (RRMM). However, its use in patients with end-stage renal disease (ESRD) undergoing hemodialysis …
jp
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Accès ouvert
2025
article
OpenAlex
Hidetsugu Kawai, Hidehito Fukushima, Yasuhito Nannya, Makoto Onizuka et autres
De novo Ph-positive MDS with the micro BCR::ABL1 (e19a2/p230) transcript is rare. Here, we report a case of MDS with multilineage dysplasia in an 86-year-old woman. Reverse transcription polymerase chain reaction (RT-PCR) showed the following karyotype: 46, XX, t(9;22)(q34.1;q11.2), i(17)(q10) [20], and …
jp
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Accès ouvert
2025
article
OpenAlex
Kaito Harada, Shino Iwata, Shinichiro Machida, Daisuke Furuya et autres
Chronic active Epstein-Barr virus infection (CAEBV) is a rare and potentially fatal condition involving EBV-infected T or natural killer cells. We herein report a 46-year-old man with CAEBV complicated by cardiomyopathy. Imaging and a biopsy revealed EBV-positive CD3+ T cell infiltration in …
jp
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Accès ouvert
2025
article
OpenAlex
Nirav Niranjan Shah, Pier Luigi Zinzani, Michael Wang, Sunita Dwivedy Nasta et autres
ABSTRACT: Relapsed/refractory (R/R) follicular lymphoma (FL) is a chronic disease often requiring multiple lines of therapy. Covalent Bruton tyrosine kinase inhibitor (BTKi) monotherapy has resulted in variable response rates, yet patients invariably experience relapse. While newer therapies such as bispecific antibodies and …
us, it, pl, jp, au, fr, ch, gb
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Accès ouvert
2025
article
OpenAlex
Yutaka Ueda, Naoshi Obara, Shikiko Ueno, Masatoshi Sakurai et autres
Paroxysmal nocturnal hemoglobinuria (PNH) is a lifelong, clonal hematologic disease posing life-threatening risks if untreated. The prognosis for PNH has improved with the advent of C5 inhibitors, which are now the standard of care where available. As treatment options continue to expand, …
jp
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