Hanwen Liu

Enhanced Transient Expression of Recombinant Human IL-2 Fc in HEK293F Cells via Optimization of Promoter-MAR Combinations and PEI-Mediated Transfection Conditions

Hanwen Liu, Y C Zhu, Yongchun Zhou, Haibo Cai

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Exopolysaccharide-rosmarinic acid complex as a phosphate replacer: dual improvement of oxidative stability and gel properties in myofibrillar proteins

Xinran Wang, Jin Hu, Yifan F. Zhang, Guohua Jiang et autres

Under a clean-label strategy, this study developed a non-covalent extracellular polysaccharide (EPS)-rosmarinic acid (RA) complex (EPS-RA) via laccase-catalyzed conjugation to enhance natural phosphate alternatives. FTIR, XRD and NMR confirmed hydrogen bonding and van der Waals interactions between EPS and RA. EPS-RA showed …

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Visible Light‐Driven Photoredox Synthesis of Sulfonylated Benzimidazoisoquinolines via 10 H ‐Phenothiazine‐Catalyzed Electron Donor–Acceptor Complexes

Zhixing Liu, Yi Lv, Ningning Li, Zi‐Rui Kuang et autres

An unmodified 10 H ‐phenothiazine is directly utilized as an efficient photocatalyst to enable ready access to sulfonylated benzo[4,5]imidazo[2,1‐ a ]isoquinoline derivatives from N ‐allyl benzimidazoles and sulfonyl chlorides. The reaction involves the formation of electron donor–acceptor complexes between phenothiazine and sulfonyl …

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Ultrasound-Energized OX40L-Expressing Biohybrid for Multidimensional Mobilization of Sustained T Cell-Mediated Antitumor Immunity and Potent Sono-Immunotherapy

Mengyun Liang, Xiaoying Kang, Hanwen Liu, Lu Zhang et autres

Harnessing immunostimulation to reinvigorate antitumor effector immune cells represents a promising strategy for tumor eradication. However, achieving durable clinical outcomes necessitates multidimensional activation to sustain robust immune responses. Here, we present an ultrasound-empowered living biohybrid that strategically mobilizes T-cell-mediated immunity for potent …

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Cyanamide-Based Cyclization Reactions for Nitrogen-Containing Heterocycles Synthesis

Yuxin Wu, Cheng‐Liang Liu, Sihan Chen, Zi‐Rui Kuang et autres

Nitrogen-containing heterocycles, such as indoles and quinolines, serve as the key scaffolds in numerous pharmaceuticals, pesticides, and natural products. The synthetic methods of nitrogen-containing heterocycles show significant scientific and industrial values. As a chemical intermediate featuring dual functional groups, cyanamide plays a …

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A chemically defined, mechanically tunable, and bioactive hyaluronic acid/alginate double-network hydrogel for liver cancer organoid construction

Yuanyuan Zhao, Junjie Gong, Hanwen Liu, Huimin Huang et autres

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A Non-Invasive Microwave Impurities Detection System Based on Supervised Descent Method

Hanwen Liu, Xuefeng He, Ni Yang

In the field of impurities detection, microwave imaging has been widely used in recent years. This paper proposes a microwave non-invasive detection method. A microwave imaging system with a set of antennas around the area to be inspected is designed, which could …

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Hypoxia-accelerating pyroptosis nanoinducers for promoting image-guided cancer immunotherapy

Dongfang Liu, Mengyun Liang, Yongyou Tao, Hanwen Liu et autres

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Slipped capital femoral epiphysis in an adult patient after surgery for pituitary tumor

Hanwen Liu, Hao Hu, Jianhua Ge, Meiyun Tan

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Intraocular Pressure Monitoring Smart Contact Lens with High Environmental Stability

Huan Yang, Hengtian Zhu, Hanwen Liu, Zhengyi Mao et autres

Abstract Smart contact lenses (SCLs), integrating various functional components, serve as a platform for wirelessly intraocular pressure (IOP) monitoring. Accurate and dynamic measurements offer crucial clinical references for patients with ocular hypertension. Nevertheless, the complex ocular environment poses great challenges, particularly for …

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Efficacy of extracorporeal shock wave therapy in the treatment of bone marrow edema in different parts of the knee joints

Hao Hu, Hanwen Liu, Kun Yu, Yinshen Liu et autres

Abstract Background The purpose of this prospective study was to evaluate the effectiveness of extracorporeal shock wave therapy (ESWT) in reducing symptoms and normalizing imaging features in periprosthetic bone marrow edema syndrome (BMES) of the knee. Methods The clinical data of 42 …

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Pdgfrα-dependent Polr3b Exon Loss Recapitulates POLR3-related Hypomyelinating Leukodystrophy Phenotypes in vivo (S2.004)

Mackenzie A. Michell‐Robinson, Kristin E. Noack Watt, Vladimir Grouza, Julia Macintosh et autres

Objective: To develop the first model of RNA Polymerase III (Pol III)-Related Hypomyelinating Leukodystrophy (POLR3-HLD) based on a POLR3B mutation. Background: POLR3-HLD is a devastating neurological disease characterized by severe diffuse hypomyelination and progressive functional decline leading to early death. It is …

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