Hong Yu

The prognostic significance of JAML and its role in remodeling the immune microenvironment via the cGAS-STING pathway in endometrial cancer

Chenfan Tian, Yuanyang Yao, Yuan Tu, Jingwei Yu et autres

Background Endometrial cancer (EC) is a major gynecological malignancy with a poor prognosis in the advanced stages. Junctional adhesion molecule-like protein (JAML) is gaining attention in cancer biology; however, its role in EC remains unclear. Methods This study integrated multi-omics data (TCGA, …

cn (code pays fourni par la source)

Blood Biomarker-Based Machine Learning Model for Predicting Cognitive Impairment in Stroke Patients

Yue Zhao, Daojun Zeng, Hong Yu, Yujie Zheng et autres

BACKGROUND: Cognitive impairment (CI) is common in stroke patients and is associated with a poor prognosis. Early and accurate identification of high-risk patients is crucial. This study aims to develop a predictive model for CI risk in stroke patients using machine learning …

cn (code pays fourni par la source)

Prognostic significance and immune infiltration analysis of HMGA2 in endometrial cancer

Peng Jiang, Jiaxin Yu, Yunfeng Zheng, Chenfan Tian et autres

Background HMGA2, as a transcription factor, facilitates oncogenesis and malignant progression by coordinating cell cycle dysregulation, compromising DNA repair machinery, and suppressing cancer cell apoptosis. However, its roles in prognostication and tumor immune microenvironment modulation in endometrial cancer (EC) remain incompletely defined. …

cn (code pays fourni par la source)

683P Aumolertinib plus anlotinib in advanced EGFR-mutant NSCLC with brain metastasis (Alot BRAIN): A single-arm, phase II study (GASTO 1063) (updated data)

Li-Kuei Chen, Jianguo Chen, Meicheng Li, Hong Yu et autres

cn (code pays fourni par la source)

Radiomic signatures of brain metastases on MRI: utility in predicting pathological subtypes of lung cancer

Linlin Sun, Shihai Luan, Liheng Yu, Huiyuan Zhu et autres

Background: The pathological sub-classification of lung cancer is crucial in diagnosis, treatment and prognosis for patients. Quick and timely identification of pathological subtypes from imaging examinations rather than histological tests could help guiding therapeutic strategies. The aim of the study is to …

cn (code pays fourni par la source)

Combination of Contrast-enhanced FlAIR and Contrast-enhanced T1WI: A Quick and Efficient Method in Detecting Brain Metastases of Lung Cancers

Linlin Sun, Shihai Luan, Xiaodan Ye, Jing Chen et autres

BACKGROUND: Some patients with suspected brain metastases (BM) could not tolerate longer scanning examinations according to the standardized MRI protocol. OBJECTIVE: The purpose of this study was to evaluate the clinical value of contrast-enhanced fast fluid-attenuated inversion recovery (CE FLAIR) imaging in …

cn (code pays fourni par la source)

KLK10/LIPH/PARD6B/SLC52A3 are promising molecular biomarkers for the prognosis of pancreatic cancer through a ceRNA network

Meng Zhang, Lin Jiang, Xin-Yun Liu, Fuxing Liu et autres

Pancreatic adenocarcinoma (PAAD) remains challenging to diagnose and treat clinically due to its difficult early diagnosis, low surgical resection rate, and high risk of postoperative recurrence and metastasis. SMAD4 is a classical mutated gene in pancreatic cancer and is lost in up …

cn (code pays fourni par la source)

OA03.03 Aumolertinib Plus Anlotinib in Advanced NSCLC with Brain Metastasis: A Single-arm, Phase II Study

Lin Chen, J. chen, Minmin Li, Hong Yu et autres

cn (code pays fourni par la source)

1378P Efficacy and safety of tunlametinib (HL-085) combined with vemurafenib in patients with advanced BRAF V600-mutated solid tumors: A multicenter, phase I study

Y-K. Shi, Yulong Zheng, Y-H. Chen, Xin Yu et autres

cn (code pays fourni par la source)

A CT-based radiomics integrated model for discriminating pulmonary cryptococcosis granuloma from lung adenocarcinoma—a diagnostic test

Bin Hu, Wei Xia, Sirong Piao, Ji Xiong et autres

Background: Chest computed tomography (CT) is a critical tool in the diagnosis of pulmonary cryptococcosis as approximately 30% of normal immunity individuals may not exhibit any significant symptoms or laboratory findings. Pulmonary cryptococcosis granuloma and lung adenocarcinoma can appear similar on noncontrast …

cn, us (code pays fourni par la source)

Clinicopathological features and survival of rare primary pulmonary lymphoepithelial carcinoma: A cohort from a single center

Kai Nie, Guangyu Tao, Lin Zhu, Yuxuan Zhang et autres

BACKGROUND: Primary pulmonary lymphoepithelial carcinoma (PLEC) is a rare subtype of nonsmall cell lung cancer. This study aimed to investigate the clinicopathological and prognostic characteristics of resected primary PLEC. MATERIALS AND METHODS: In this retrospective study, 95 consecutive patients with primary PLEC, …

cn, gb (code pays fourni par la source)

Data from Infiltrating T Cells Promote Bladder Cancer Progression via Increasing IL1→Androgen Receptor→HIF1α→VEGFa Signals

Le Tao, Jianxin Qiu, Ming Jiang, Wenbin Song et autres

Abstract The tumor microenvironment impacts tumor progression and individual cells, including CD4+ T cells, which have been detected in bladder cancer tissues. The detailed mechanism of how these T cells were recruited to the bladder cancer tumor and their impact on bladder …