Xin-Yun Liu

Defactinib inhibits focal adhesion kinase to attenuate pancreatic cancer growth via PI3K/AKT pathway modulation

Hui-Deng Long, Hao Wang, Wei Xiang, Tian-Yin Ma et autres

cn, us (code pays fourni par la source)

Regulation of tumorigenesis by cellular senescence: Mechanisms and pathways in liver cancer and cholangiocarcinoma

Tao Lu, Si-Yi Zou, Changsheng Dong, S. Jiang et autres

cn, us (code pays fourni par la source)

Artificial intelligence-driven early screening and diagnosis of pancreatic cancer: technical innovations, clinical applications, and precision medicine strategies

Y Li, Dan Li, Y Zhou, Wen-Er Wang et autres

BACKGROUND: Pancreatic cancer is characterized by prolonged subclinical progression, molecular heterogeneity, and late clinical presentation, resulting in diagnosis predominantly at advanced stages. Current screening approaches lack sufficient sensitivity and scalability, underscoring the need for risk-adapted early detection strategies. Artificial intelligence (AI) offers …

cn, us (code pays fourni par la source)

TMEM158-mediated TGF-β signaling pathway modulates the sensitivity of TP53-deficient osteosarcoma to USP14 inhibitors

Zi-Yu Chen, Miersalijiang Yasen, S. Jiang, Ziyi Ye et autres

cn (code pays fourni par la source)

TMEM158-mediated TGF-β signaling pathway modulates the sensitivity of TP53-deficient osteosarcoma to USP14 inhibitors

Ziyu Chen, Miersalijiang Yasen, S. Jiang, Ziyi Ye et autres

cn (code pays fourni par la source)

TOPBP1 as a potential predictive biomarker for enhanced combinatorial efficacy of olaparib and AZD6738 in PDAC

Jiacheng Wang, Yijin Gu, Qin-Xin Yang, Jia Liu et autres

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive and often lethal malignancy, requiring the development of enhanced therapeutic approaches. The DNA damage response (DDR) pathway is frequently altered during PDAC development, leading to an increased occurrence of DNA damage. DNA topoisomerase II-binding …

cn (code pays fourni par la source)

The power and the promise of synthetic lethality for clinical application in cancer treatment

Qianwen Liu, Zhiwen Yang, Qing-Hai Tang, Wen-Er Wang et autres

Synthetic lethality is a phenomenon wherein the simultaneous deficiency of two or more genes results in cell death, while the deficiency of any individual gene does not lead to cell death. In recent years, synthetic lethality has emerged as a significant topic …

cn (code pays fourni par la source)

The power and the promise of CAR-mediated cell immunotherapy for clinical application in pancreatic cancer

Haoyu Tang, Yizhi Cao, Yiwei Zhou, Yu‐Shui Ma et autres

BACKGROUND: Pancreatic cancer, referred to as the "monarch of malignancies," is a neoplastic growth mostly arising from the epithelial cells of the pancreatic duct and acinar cells. This particular neoplasm has a highly unfavorable prognosis due to its marked malignancy, inconspicuous initial …

cn (code pays fourni par la source)

KLK10/LIPH/PARD6B/SLC52A3 are promising molecular biomarkers for the prognosis of pancreatic cancer through a ceRNA network

Meng Zhang, Lin Jiang, Xin-Yun Liu, Fuxing Liu et autres

Pancreatic adenocarcinoma (PAAD) remains challenging to diagnose and treat clinically due to its difficult early diagnosis, low surgical resection rate, and high risk of postoperative recurrence and metastasis. SMAD4 is a classical mutated gene in pancreatic cancer and is lost in up …

cn (code pays fourni par la source)