Yuting Bai

Predicting the molecular mechanism of ginger targeting PRMT1/BTG2 axis to inhibit gastric cancer based on WGCNA and machine algorithms

Guoqing Chen, Boyun Gou, Yuhua Du, Ziying Zhou et autres

OBJECTIVE: The aim of this study was to screen the biomarkers of ginger against gastric cancer (GC) by network pharmacology, WGCNA and machine algorithms. To find the upstream transcription factors and downstream signaling proteins constituting the signaling axis, so as to predict …

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Exploring the potential mechanism of atorvastatin in regulating ferroptosis as a treatment for heart failure based on network pharmacology

Yuting Bai, Yiqi Wang, Yanmin Liu, Zhijia Gong et autres

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Visualising research trends and hotspots in ferroptosis: a decade of insights into iron-dependent cell death and clinical diseases

Meng-Zhen Shi, Qianqian Wu, Xiaoqian Liu, Yuting Bai et autres

To explore the research hotspots and frontier trends of ferroptosis and its association with clinical diseases both in China and internationally over the past decade. Utilizing the CNKI, PubMed, and Web of Science literature databases as data sources, we employed CiteSpace 6.2.R4 …

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Network pharmacology study and in vitro experimental validation of Xiaojianzhong decoction against gastric cancer

Guoqing Chen, Yi Nan, Ning Na, Shi-Cong Huang et autres

BACKGROUND Cancer is one of the most serious threats to human health worldwide. Conventional treatments such as surgery and chemotherapy are associated with some drawbacks. In recent years, traditional Chinese medicine treatment has been increasingly advocated by patients and attracted attention from …

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Hypoxia and ferroptosis

Xiaoqian Liu, Meng-Zhen Shi, Yuting Bai, Xiaoling Su et autres

Ferroptosis is a novel, iron-dependent cell death characterized by the excessive accumulation of ferroptosis lipid peroxides ultimately leading to oxidative damage to the cell membrane. Iron, lipid, amino acid metabolism, and other signaling pathways all control ferroptosis. Numerous bodily tissues experience hypoxia …

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Activation of GABAergic neurons in anterior cingulate cortex and their impacts on pulpitis-induced pain

Li‐An Wu, Jialin Si, Zhuo Yu, Yan Xia et autres

Abstract Dental pulpitis, a highly prevalent condition associated with severe pain, often poses a challenge for conventional analgesics, which exhibit limited efficacy in providing effective relief. Previous researches have focused primarily on the dental pulp nerve fibers, trigeminal ganglion, and medullary dorsal …

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Exploring the pharmacological mechanism of Artemisia annua herba based on network pharmacology

Qing Wu, Can Luo, Xiaowu Zhong, Yulei Xie et autres

This work focused on conducting pharmacological network analysis for identifying the mechanism of components of Artemisia annua herba (AAH) and corresponding target proteins related to cancer. We acquired chemical constituents of AAH based on traditional Chinese medicine systems pharmacology database (TCMSP), and …

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Discussion on the mechanism of action of Salvia miltiorrhiza in the treatment of prostate cancer based on network pharmacology

Jiajun Chen, Yuting Bai, Xin Chen

The purpose of this study was to explore the mechanism of action of Salvia miltiorrhiza in the treatment of prostate cancer (PCa) based on the network pharmacology approach, and to provide a basis for rational clinical use and cellular experiments. The method …

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Hypoxia protects H9c2 cells against Ferroptosis through SENP1-mediated protein DeSUMOylation

Yuting Bai, Fengjun Xiao, Hua Wang, Ri-Li Ge et autres

Hypoxia affects proliferation, differentiation, as well as death of cardiomyocyte, and plays an important role in the development of myocardial ischemia. However, the detailed mechanisms through which hypoxia regulates cardiomyocyte ferroptosis have not been explored. In this study, we revealed that hypoxia …

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Regeneration of Functional Neurons After Spinal Cord Injury via in situ NeuroD1-Mediated Astrocyte-to-Neuron Conversion

Brendan Puls, Yan Ding, Fengyu Zhang, Mengjie Pan et autres

Spinal cord injury (SCI) often leads to impaired motor and sensory functions, partially because the injury-induced neuronal loss cannot be easily replenished through endogenous mechanisms. In vivo neuronal reprogramming has emerged as a novel technology to regenerate neurons from endogenous glial cells …

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Development of Neuroregenerative Gene Therapy to Reverse Glial Scar Tissue Back to Neuron-Enriched Tissue

Lei Zhang, Zhuofan Lei, Ziyuan Guo, Zifei Pei et autres

Nerve injury often causes neuronal loss and glial scar formation. We have recently demonstrated NeuroD1-mediated direct conversion of reactive glial cells into functional neurons in adult mouse brains. Here, we further investigate whether such direct glia-to-neuron conversion technology can reverse glial scar …

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Ferulic acid attenuates oxidative DNA damage and inflammatory responses in microglia induced by benzo(a)pyrene

Yongfen Bao, Qingjie Chen, Yushuang Xie, Zhe Tao et autres

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