Yongfen Bao

OTU deubiquitinases as immune-circuit editors: from human immunopathology to therapeutic prioritization

Yi Guo, Yue Song, Chenxin Wang, Rui Xiong et autres

OTU deubiquitinases are linkage-sensitive ubiquitin editors that regulate immune circuits, human immunopathology, and emerging therapeutic opportunities. By remodeling K48-, K63-, and linear ubiquitin chains, they control protein stability, scaffold assembly, and signal amplitude across nuclear factor κB (NF-κB), and tumor-immune pathways. Individual …

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KDM5B drives acute liver injury by impairing autophagy and activating cGAS-STING signaling via binding to ATG16L1

Lihua Qu, Horng D. Ou, Yaoyao Ma, Jiangyue Wang et autres

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Immunoinflammation and post-translational modifications in the aging process

Jiaqi Xiao, Xuan Qin, Wentao Chen, Xinyu Que et autres

Aging is an intrinsic biological decline marked by multidimensional alterations spanning molecular, cellular, tissue, and organ levels. One hallmark of aging is the progressive deterioration of immune function, a condition referred to as immunosenescence. This process often involves a persistent, mild, and …

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Histone demethylases in autophagy and inflammation

Yaoyao Ma, Wenting Lv, Yi Chen Guo, Tong Yin et autres

Autophagy dysfunction is associated with changes in autophagy-related genes. Various factors are connected to autophagy, and the mechanism regulating autophagy is highly complicated. Epigenetic changes, such as aberrant expression of histone demethylase, are actively associated not only with oncogenesis but also with …

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Regulation of autophagy and cellular signaling through non-histone protein methylation

Yongfen Bao, Yaoyao Ma, Wentao Huang, Yujie Bai et autres

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Efficient TurboID-based proximity labelling method for identifying terminal sialic acid glycosylation in living cells

Wu Liu, Yunfeng Long, Yongfen Bao, Yang Li et autres

TurboID, a proximity labelling method based on mutant biotin ligase, is an efficient new technique for recognizing protein-protein interactions and has been successfully applied to living cells. Sialic acid is typically the terminal monosaccharide attached to many glycoproteins and plays many important …

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Berberine ameliorates neuronal AD ‐like change via activating Pi3k/ PGCε pathway

Ning‐hua Wu, Wu Liu, Jiawen Wang, Yanqi Han et autres

IR (insulin resistance) in diabetic brain gave rise to the generation of toxic factor Aβ42 and axon collapse which were the marker of AD (Alzheimer's disease)-like lesions in the circumstance of diabetes mellitus. But the underling molecular mechanism was not clear. Chronic …

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Ferulic acid attenuates oxidative DNA damage and inflammatory responses in microglia induced by benzo(a)pyrene

Yongfen Bao, Qingjie Chen, Yushuang Xie, Zhe Tao et autres

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MiR‐28‐5p relieves neuropathic pain by targeting Zeb1 in CCI rat models

Yongfen Bao, Suhan Wang, Yushuang Xie, Kehua Jin et autres

MicroRNAs (miRNAs) are recognized as significant regulators of neuropathic pain. Moreover, neuroinflammation can contribute a lot to the progression of neuropathic pain. MiR-28-5p has been reported to be involved in many pathological diseases. However, little is known about the function of miR-28-5p …

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Effects of benzo(a)pyrene on cell immune activity and HSP70 of human lymphocytes in vitro

Yongfen Bao

Human lymphocytes(721.221)were treated with benzo(a)pyrene[B(a)P]at different doses(0.125,0.250,0.500,1.000,2.000,4.000,8.000,16.000μmol/L)for 16hto study the cell viability,imroune activity and HSP70expression in vitro.Cells at exponential growth phase in vitro planted in 96wells microplates were treated by low doses of 0.125-1.000μmol/L and high doses of 2.000-16.000μmol/L B(a)P for 16hrespectively.MTT …

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