Hao Wang

Virtual Staining-Enabled Colorectal Cancer Metastasis Detection in Liquid Cytology Based on Digital Holography

Xi Xiao, Ran Peng, Hao Wang, Feng Pan

Colorectal cancer (CRC) remains a leading cause of cancer-related mortality, and detecting circulating tumor cells (CTCs) is crucial for early diagnosis and metastasis monitoring. Conventional staining-based cytology is costly, time-consuming, and often compromises sample integrity. In this study, we employed a combined …

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Quantitative analysis of [18F]CHL2310, a novel PET ligand for cholesterol 24-Hydroxylase, in nonhuman primate brain

Huiyi Wei, Junqi Hu, A. Haider, Jun-Jie Wei et autres

Cholesterol 24-hydroxylase (CYP46A1) is a brain-specific enzyme catalyzes the conversion of cholesterol into 24S-hydroxycholesterol, thereby playing a pivotal role in maintaining cerebral cholesterol homeostasis. Dysregulation of this pathway has been implicated in various neurological disorders, including Alzheimer’s disease, Huntington’s disease, epilepsy, and …

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MRI-based habitat analysis for pathologic response prediction after neoadjuvant chemoradiotherapy in rectal cancer: a multicenter study

Qiaoling Chen, Qianwen Zhang, Zhihui Li, Shaoting Zhang et autres

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Endothelium-specific endoglin triggers astrocyte reactivity via extracellular vesicles in a mouse model of Alzheimer’s disease

Pingao Zhang, Chenghuan Song, Jiyun Shi, Zijie Wei et autres

BACKGROUND: Alzheimer's disease (AD) is a multifaceted neurodegenerative disorder with a complex etiology that extends beyond the well-documented amyloid-β and tau pathologies. Growing evidence implicates cerebrovascular dysfunction, particularly brain microvascular endothelial cells (BMECs) dysfunction, as an early contributor to AD pathogenesis. However, …

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Role of Radiotherapy in PCNSL within the Current Therapeutic Landscape: a Comprehensive Review

Min Li, Ran Peng, Fang Bao, Hongmei Jing et autres

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PCL-PEtOx-based Crystalline-core Micelles for the Targeted Delivery of Paclitaxel and Trabectedin in Ovarian Cancer Therapy

Zixiu Du, Wei Wei, Hao Wang, Yinuo Li et autres

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Microglial circDlg1 modulates neuroinflammation by blocking PDE4B ubiquitination-dependent degradation associated with Alzheimer's disease

Jiyun Shi, Chenghuan Song, Pingao Zhang, Jing Wang et autres

The novel microglia-upregulated circDlg1 tightly involves in neuroinflammation in APP/PS1 mice via determining the protein fate of PDE4B. Microglial loss of circDlg1 promotes microglial protective response to Aβ deposition and relieves neuroinflammation, thus suggesting a potential therapeutic strategy that specifically targets the …

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N6-methyladenosine regulators in hepatocellular carcinoma: investigating the precise definition and clinical applications of biomarkers

Xiaokai Yan, Yao Qi, Xinyue Yao, Lulu Yin et autres

BACKGROUND: Accurately identifying effective biomarkers and translating them into clinical practice have significant implications for improving clinical outcomes in hepatocellular carcinoma (HCC). In this study, our objective is to explore appropriate methods to improve the accuracy of biomarker identification and investigate their …

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Prediction of pathological response and lymph node metastasis after neoadjuvant therapy in rectal cancer through tumor and mesorectal MRI radiomic features

Siyuan Qin, Ke Liu, Yongye Chen, Yan Zhou et autres

Establishing predictive models for the pathological response and lymph node metastasis in locally advanced rectal cancer (LARC) treated with neoadjuvant chemoradiotherapy (nCRT) based on MRI radiomic features derived from the tumor and mesorectal compartment (MC). This study included 209 patients with LARC …

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De novo prediction of functional effects of genetic variants from DNA sequences based on context-specific molecular information

Jiaxin Yang, Sikta Das Adhikari, Hao Wang, Binbin Huang et autres

Deciphering the functional effects of noncoding genetic variants stands as a fundamental challenge in human genetics. Traditional approaches, such as Genome-Wide Association Studies (GWAS), Transcriptome-Wide Association Studies (TWAS), and Quantitative Trait Loci (QTL) studies, are constrained by obscured the underlying molecular-level mechanisms, …

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Preoperative controlling nutritional status as an optimal prognostic nutritional index to predict the outcome for colorectal cancer

Lixiang Liu, Hao Wang, Bo Gao, Tingting Xu et autres

BACKGROUND The controlling nutritional status (CONUT) score effectively reflects a patient’s nutritional status, which is closely related to cancer prognosis. This study investigated the relationship between the CONUT score and prognosis after radical surgery for colorectal cancer, and compared the predictive ability …

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Current developments and opportunities of pluripotent stem cells-based therapies for salivary gland hypofunction

Wenpeng Song, Huan Liu, Yingying Su, Qian Zhao et autres

Salivary gland hypofunction (SGH) caused by systemic disease, drugs, aging, and radiotherapy for head and neck cancer can cause dry mouth, which increases the risk of disorders such as periodontitis, taste disorders, pain and burning sensations in the mouth, dental caries, and …

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