Current developments and opportunities of pluripotent stem cells-based therapies for salivary gland hypofunction
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Le résumé fourni par la source
Salivary gland hypofunction (SGH) caused by systemic disease, drugs, aging, and radiotherapy for head and neck cancer can cause dry mouth, which increases the risk of disorders such as periodontitis, taste disorders, pain and burning sensations in the mouth, dental caries, and dramatically reduces the quality of life of patients. To date, the treatment of SGH is still aimed at relieving patients' clinical symptoms and improving their quality of life, and is not able to repair and regenerate the damaged salivary glands. Pluripotent stem cells (PSCs), including embryonic stem cells (ESCs), induced pluripotent stem cells (iPSCs), and extended pluripotent stem cells (EPSCs), are an emerging source of cellular therapies that are capable of unlimited proliferation and differentiation into cells of all three germ layers. In recent years, the immunomodulatory and tissue regenerative effects of PSCs, their derived cells, and paracrine products of these cells have received increasing attention and have demonstrated promising therapeutic effects in some preclinical studies targeting SGH. This review outlined the etiologies and available treatments for SGH. The existing efficacy and potential role of PSCs, their derived cells and paracrine products of these cells for SGH are summarized, with a focus on PSC-derived salivary gland stem/progenitor cells (SGS/PCs) and PSC-derived mesenchymal stem cells (MSCs). In this Review, we provide a conceptual outline of our current understanding of PSCs-based therapy and its importance in SGH treatment, which may inform and serve the design of future studies.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Current developments and opportunities of pluripotent stem cells-based therapies for salivary gland hypofunction
- Date Crossref
- 19/01/2024
- Éditeur
- Frontiers Media SA
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Capital Medical University Department of Stomatology pays non établi dans la noticeUniversité ou école supérieure
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Beijing Tian Tan Hospital pays non établi dans la noticeÉtablissement de santé
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Chinese Academy of Medical Sciences & Peking Union Medical College pays non établi dans la noticeUniversité ou école supérieure
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School of Basic Medicine Beijing Laboratory of Oral Health pays non établi dans la noticeUniversité ou école supérieure
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Allife Medicine Inc. Research and Development Department pays non établi dans la noticeEntreprise
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School of Basic Medical Sciences Biochemistry and Molecular Biology pays non établi dans la noticeUniversité ou école supérieure
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Eye Hospital Department of Stomatology pays non établi dans la noticeÉtablissement de santé
Department of Stomatology — Capital Medical University, Beijing Tian Tan Hospital et Chinese Academy of Medical Sciences & Peking Union Medical College, avec 4 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.