Yuan Gao

Developmental and cellular vulnerabilities underlie genetic architecture of schizophrenia

Yong Wu, Yuan Gao, Miao Li, Chuyi Zhang et autres

cn, hk (code pays fourni par la source)

IL-6 signaling drives treg dysfunction and pathogenic Th1-like polarization in major depressive disorder

Yao Gao, Zihan Lei, Xianyan Zhan, Yifan Ren et autres

Major depressive disorder (MDD) is pathologically associated with inflammatory-immune dysregulation. While regulatory T cells (Tregs) are essential for immune homeostasis, clinical evidence have reported paradoxical dynamics (deficiency vs. expansion) of peripheral Tregs in MDD patients. The plasticity of Tregs and microenvironmental reprogramming …

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Trans-ancestry genome-wide analyses of bipolar disorder in East Asian and European populations improve genetic discovery

Chuyi Zhang, Miao Li, Ping Sun, Li Hui et autres

cn, hk, jp (code pays fourni par la source)

Cognitive impairment in bipolar disorder associated with abnormal serum short-chain fatty acids and cytokines

Yajuan Fan, Binbin Zhao, Min Jia, Zhiyang Qi et autres

OBJECTIVE: We investigated changes in serum short-chain fatty acids (SCFAs) levels in patients with bipolar disorder (BD) and explored the relationship between these levels and peripheral cytokines and their impact on cognitive function. METHODS: This study enrolled 64 patients with BD and …

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Double-hit of MIA and Nod2 deficiency induces sex-specific offspring behavioral abnormalities through placental dysregulation

Zhen‐Bo Cao, Xinyu Zhang, Fengjie Gao, Chuyao Wang et autres

Abstract The pathogenesis of neuropsychiatric disorders, including autism spectrum disorder and schizophrenia, originates from complex interactions between genetic susceptibility and early environmental exposure. Infectious challenges during pregnancy are well-known environmental risk factors for neurodevelopmental disorders. Our previous research reported the interplay between …

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Gender-specific associations of blood immune markers with symptoms and cognitive function in major depressive disorder: a cross-sectional observational study

Ding Yang, Xianyan Zhan, Yajuan Fan, Yuan Gao et autres

BACKGROUND: Cognitive impairments constitute a core manifestation of major depressive disorder (MDD), albeit the precise mechanisms governing these impairments remain elusive. Inflammation may contribute to cognitive impairment and clinical symptoms in MDD. We conducted an investigation into the inflammatory markers present in …

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Distinct Gut Microbial Signatures and Diminished Anti-Inflammatory Effect of Short-Chain Fatty Acids in Schizophrenia With Immune Activation

Xiaoyan He, Yuan Gao, Yudan Zhang, Zai Yang et autres

BACKGROUND AND HYPOTHESIS: A subset of patients with schizophrenia (SCZ) exhibit subclinical immune activation. However, the gut microbial features of this subgroup and their interplay with the immune function remain poorly understood. This study aimed to identify the gut microbiome signature of …

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Gut microbiota dysbiosis promotes cognitive impairment via bile acid metabolism in major depressive disorder

Min Jia, Yajuan Fan, Qingyan Ma, Ding Yang et autres

Evidence suggests that complex interactions among the gut microbiome, metabolic abnormalities, and brain have important etiological and therapeutic implications in major depressive disorder (MDD). However, the influence of microbiome-gut-brain cross-talk on cognitive impairment in MDD remains poorly characterized. We performed serum metabolomic …

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Effects of Aspergillus flavus infection on multi-scale structures and physicochemical properties of maize starch during storage

Xiaoyu Tian, Yafan Hu, Yuan Gao, Gang Wang et autres

cn, hu (code pays fourni par la source)

[Eye acupuncture improves cerebral ischemia reperfusion injury by improving autophagy via ATF6 pathway in cerebral ischemia reperfusion injury rats].

Shu-Nuo He, Xiaowei Han, Qian Pan, Xiande Ma et autres

OBJECTIVE: To explore the effect of eye acupuncture on autophagy and expressions of autophagy-related proteins Beclin1, LC3B, ATF6 and XBP1 in the infarction area of brain tissue in rats with acute cerebral ischemia-reperfusion injury (CIRI), so as to explore its mechanisms underlying …

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Selenium Deficiency Leads to Inflammation, Autophagy, Endoplasmic Reticulum Stress, Apoptosis and Contraction Abnormalities via Affecting Intestinal Flora in Intestinal Smooth Muscle of Mice

Fuhan Wang, Ni Sun, Hanqin Zeng, Yuan Gao et autres

Selenium (Se) is a micronutrient that plays a predominant role in various physiological processes in humans and animals. Long-term lack of Se will lead to many metabolic diseases. Studies have found that chronic Se deficiency can cause chronic diarrhea. The gut flora …

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Astragalus polysaccharides protects against acute leptospirosis by glycolysis-depended priming effect

Wenlong Zhang, Ning Song, Yuan Gao, Xufeng Xie et autres

Leptospirosis, caused by pathogenic leptospira, is a neglected infectious disease that causes acute kidney injury, bleeding disorders, and even death. People can become infected with leptospirosis when they travel into epidemic areas. Except for vaccines and antibiotics, there are few reports of …

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