Yan Chen

Acox2 deficiency induces cardiac dysfunction via cross-organ metabolic reprogramming in mice

Cancan Yao, Yan Chen, Zhouping Lu, Ke Cai et autres

Abstract Background Secondary cardiomyopathies are a major cause of heart failure (HF) with diverse etiologies and high mortality rates. For example, over 50% of patients with end-stage liver disease develop cardiac dysfunction, clinically termed cirrhotic cardiomyopathy (CCM). While serum metabolites mediating cross-organ …

cn, es (code pays fourni par la source)

The therapeutic effect of exosomes in type 2 diabetes mellitus and its complications

Yingying Liu, Jinpeng Wang, Yunwei Sun, Yan Chen

Exosomes are a type of nanoscale extracellular vesicle secreted by cells, with a diameter of approximately 30-150 nm, which carry important biological molecules such as proteins, lipids, and RNA, functioning as messengers between cells and playing a central role in cell communication. …

cn (code pays fourni par la source)

Integrin-mediated SPP1 signaling from macrophages orchestrates extracellular matrix remodeling and chondrogenesis in heterotopic ossification

Kaiqiang Sun, Yan Chen, Chenglong Ji, Linhui Han et autres

BACKGROUND: Differentiation of mesenchymal progenitor cells (MPCs) is critical pre-requisition for the progression of heterotopic ossification (HO). However, the factors that initiate MPC differentiation remain elusive. This study aims to investigate the temporal crosstalk between macrophages and MPCs during HO, and identified …

cn (code pays fourni par la source)

Comprehensive assessment of dietary micronutrient profiles and their effects on hemoglobin levels and anemia: provincial nutrition and health monitoring

Yan Wang, Yun Lin, Ye Lv, Hua Gao et autres

Background: Micronutrients play a major role in regulating public health. Inadequate intake of micronutrients is a frequent and potentially hazardous occurrence that may lead to the development of common pathologies, such as anemia, a widespread health concern. This study aimed to estimate …

cn (code pays fourni par la source)

[Development and application of intensive care unit digital intelligence multimodal shift handover system].

Xue Bai, Wei Fang, ZY Wei, Yan Chen et autres

OBJECTIVE: To develop a digital intelligent multimodal shift handover system for the intensive care unit (ICU) and evaluate its application effect in ICU shift handovers. METHODS: A research and development team was established, consisting of 1 department director, 1 head nurse, 3 …

cn (code pays fourni par la source)

AKR1B1/NAT10 Mediate IL4I1 ac4C Modification to Regulate Tryptophan Metabolism and Promote Multiple Myeloma Proliferation

Rongfang Wei, Yaping Liao, Shuping Lai, Jingxian Chen et autres

Mitochondrial dysfunction in diabetic ulcers: pathophysiological mechanisms and targeted therapeutic strategies

Pan Yu, Lin Y. Chen, Yan Chen, Elizabeth Rosalind Thomas et autres

Diabetic foot ulcers (DFUs) are a serious complication of diabetes, characterized by delayed wound healing, recurrent infection, and risk of amputation. Mitochondrial dysfunction has emerged as a central pathological mechanism underlying impaired wound healing. Persistent hyperglycemia triggers a cascade of mitochondrial abnormalities …

cn, in (code pays fourni par la source)

Targeted Inhibition of cGAS/STING signaling induced by aberrant R-Loops in the nucleus pulposus to alleviate cellular senescence and intervertebral disc degeneration

Dan Wu, Yan Chen, Linhui Han, Fudong Li et autres

Intervertebral disc degeneration (IVDD) is a significant contributor to chronic low back pain and disability worldwide, yet effective treatment options remain limited. Through integrative analysis of single-cell RNA-seq data from intervertebral discs (IVDs), we have firstly uncovered that the aberrant accumulation of …

cn (code pays fourni par la source)

Construction of a PANoptosis-Related Gene Signature for Diabetic Nephropathy

Geng Li, Yingying Liu, Yunwei Sun, Yan Chen

INTRODUCTION: Diabetic nephropathy (DN) is a serious complication of diabetes. In this study, we aimed to develop a diagnostic model for DN based on PANoptosis-related genes. METHODS: PANoptosis-related differentially expressed gene (DEGs) associated with DN were identified in the GSE96804 and GSE142025 …

cn (code pays fourni par la source)

Wuda Granule Alleviates DSS-Induced Colitis in Mice by Inhibiting Inflammation, Protecting Intestinal Barrier and Reducing Oxidative Stress Through Nrf2/Keap1/HO-1 Pathway

Tao Wang, Yanghui Ou, Wenjun Xiong, Lijie Luo et autres

Background: Colitis, a inflammatory disorder of the colon, causes significant morbidity and declines quality of life. Despite treatment advancements, effective therapies remain limited. Wuda Granules (WDG), a traditional medicine formula, is clinically used for intestinal obstruction and gastrointestinal recovery through its anti-inflammatory …

cn (code pays fourni par la source)

Glycolysis‐Derived Lactate Induces ACSL4 Expression and Lactylation to Activate Ferroptosis during Intervertebral Disc Degeneration

Kaiqiang Sun, Yangyang Shi, Yan Chen, Shunmin Wang et autres

The abnormal activation of the inflammatory microenvironment is frequently accompanied by metabolic changes that affect the development of various diseases. However, the relationship between metabolic reprogramming and intervertebral disc degeneration (IVDD) remains unclear. This study aims to reveal the metabolic changes in …

cn (code pays fourni par la source)

PLGA confers upon conventional nonfluorescent molecules luminescent properties to trigger 1O2-induced pyroptosis and immune response in tumors

Lan Zou, Rui Wang, Mengnan Zhao, Yuke Li et autres

Pyroptosis, a recently identified cellular demise regulated by gasdermin family proteins, is emerging as a promising avenue in cancer immunotherapy. However, the realm of light-controlled pyroptosis in cancer cells remains largely unexplored. In this study, we took a deliberate approach devoid of …

cn (code pays fourni par la source)