Shuping Lai

AKR1B1/NAT10 Mediate IL4I1 ac4C Modification to Regulate Tryptophan Metabolism and Promote Multiple Myeloma Proliferation

Rongfang Wei, Yaping Liao, Shuping Lai, Jingxian Chen et autres

PO-07-079 CARDIAC ARREST IN COVID-19 PATIENTS: A COMPARATIVE STUDY OF RISK FACTORS AND VENTRICULAR ARRHYTHMIC COMORBIDITIES

Lorelle Sun, Fatima Zohra Khamissi, Shuping Lai, Amy Pan et autres

HEAT SHOCK PROTEINS AND MITOCHONDRIAL INJURY: EXPLORING THE LINK BETWEEN COVID-19, HIV, AND SUDDEN CARDIAC DEATH

Lorelle Sun, Robert Aryee, Shuping Lai, Paige Johnson et autres

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Targeting CLK2 and serine/arginine‐rich splicing factors inhibits multiple myeloma through downregulating RAE1 by nonsense‐mediated mRNA decay mechanism

Yang Liu, Yaping Liao, Shuping Lai, Xiaoyan Wu et autres

Multiple myeloma (MM) is closely related to abnormal RNA splicing in its pathogenesis. CDC2-like kinase-2 (CLK2) regulates RNA splicing by phosphorylating serine/arginine-rich splicing factors (SRSFs), but the role of CLK2 in MM remains undefined. This study was to explore the role and …

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Profibrotic COVID-19 subphenotype exhibits enhanced localized ER-dependent HSP47+ expression in cardiac myofibroblasts in situ

Elizabeth Rogers Jacobs, Gracious R. Ross, Nathan Padilla, Amy Pan et autres

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Nuclear damage in LMNA mutant iPSC-derived cardiomyocytes is associated with impaired lamin localization to the nuclear envelope

Melanie Wallace, Hind C. Zahr, Shriya Perati, Chloé D. Morsink et autres

The LMNA gene encodes the nuclear envelope proteins Lamins A and C, which comprise a major part of the nuclear lamina, provide mechanical support to the nucleus, and participate in diverse-intracellular signaling. LMNA mutations give rise to a collection of diseases called …

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Carvedilol Phenocopies PGC-1α Overexpression to Alleviate Oxidative Stress, Mitochondrial Dysfunction and Prevent Doxorubicin-Induced Toxicity in Human iPSC-Derived Cardiomyocytes

Nnamdi Uche, Qiang Dai, Shuping Lai, Kurt D. Kolander et autres

Doxorubicin (DOX), one of the most effective and widely used anticancer drugs, has the major limitation of cancer treatment-related cardiotoxicity (CTRTOX) in the clinic. Reactive oxygen species (ROS) generation and mitochondrial dysfunction are well-known consequences of DOX-induced injury to cardiomyocytes. This study …

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Collagen‐Specific HSP47 + Myofibroblasts and CD163 + Macrophages Identify Profibrotic Phenotypes in Deceased Hearts With SARS‐CoV‐2 Infections

Andrii Puzyrenko, Elizabeth Rogers Jacobs, Nathan Padilla, Adam Devine et autres

Background Cardiac fibrosis complicates SARS‐CoV‐2 infections and has been linked to arrhythmic complications in survivors. Accordingly, we sought evidence of increased HSP47 (heat shock protein 47), a stress‐inducible chaperone protein that regulates biosynthesis and secretion of procollagen in heart tissue, with the …

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Cardiac Profibrotic Phenotype Evokes Er-Stress Dependent Pathways During Ecm Remodeling with Covid-19 in Situ

Elizabeth Rogers Jacobs, Gracious R. Ross, Nathan Padilla, Amy Pan et autres

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Promoting Mitochondrial Biogenesis Protects against Doxorubicin‐Induced Cardiomyocyte Injury

Nnamdi Uche, Shuping Lai, Qiang Dai, Ivor J. Benjamin

Although anthracyclines such as doxorubicin (DOX) are highly effective chemotherapeutic agents and widely used for various malignancies, they are known to cause dose‐related and life‐threatening cardiotoxicity. This well‐recognized and unpredictable complication of anthracycline therapy may be either permanent and/or reversible, leading to …

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Modeling LMNA-associated Muscular Dystrophy in Drosophila and iPS Cell-Derived Cardiomyocytes Revealed Loss of Redox Homeostasis

Jose L. Rios-Monterrosa, Gary S. Coombs, Shuping Lai, Qiang Dai et autres

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Modulation of muscle redox and protein aggregation rescues lethality caused by mutant lamins

Gary S. Coombs, Jose L. Rios-Monterrosa, Shuping Lai, Qiang Dai et autres

Mutations in the human LMNA gene cause a collection of diseases called laminopathies, which includes muscular dystrophy and dilated cardiomyopathy. The LMNA gene encodes lamins, filamentous proteins that form a meshwork on the inner side of the nuclear envelope. How mutant lamins …

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