Fudong Li

A Decoy‐Receptor‐Armed Biomimetic Nanotherapeutic With Inherent Tropism for Conserved Pathogenic Macrophages for Treating Osteoarthritis and Intervertebral Disc Degeneration

Fudong Li, Bin Zhang, Zhiqiu Zhang, Bing Zheng et autres

ABSTRACT Osteoarthritis (OA) and intervertebral disc degeneration (IVDD) are debilitating musculoskeletal disorders driven by shared inflammatory pathologies, yet lack effective disease‐modifying therapies. Pro‐inflammatory macrophages are central to their pathogenesis, but their selective therapeutic modulation remains a major challenge. Here, we first used …

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Deformation and failure evolution mechanism of inherently anisotropic sedimentary rocks under true-triaxial stress

Fudong Li, Tianyu Chen, Derek Elsworth, Xiaojun Yu et autres

Understanding the mechanical behavior and failure characteristics of anisotropic sedimentary rocks under true-triaxial in-situ stress conditions is critical in understanding and mitigating damaging formation slippage in subsurface reservoirs and containment structures. In particular, threshold conditions where structure dominates over intact failure remain …

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Targeted Inhibition of cGAS/STING signaling induced by aberrant R-Loops in the nucleus pulposus to alleviate cellular senescence and intervertebral disc degeneration

Dan Wu, Yan Chen, Linhui Han, Fudong Li et autres

Intervertebral disc degeneration (IVDD) is a significant contributor to chronic low back pain and disability worldwide, yet effective treatment options remain limited. Through integrative analysis of single-cell RNA-seq data from intervertebral discs (IVDs), we have firstly uncovered that the aberrant accumulation of …

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LGR6 modulates intervertebral disc degeneration through regulation of macrophage efferocytosis

Fudong Li, Yangyang Shi, Jun Chen, Jingchuan Sun et autres

BACKGROUND AND OBJECTIVES: Intervertebral disc degeneration (IVDD) is a leading cause of chronic low back pain, characterized by extracellular matrix (ECM) degradation, excessive inflammation activation, and increased cell apoptosis. LGR6, a receptor known for its role in tissue regeneration, has recently been …

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Experimental investigation on the failure mechanism of water-bearing sedimentary rocks under true-triaxial stress

Fudong Li, Tianyu Chen, Gaojun Shan, Liangliang Ma et autres

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Glycolysis‐Derived Lactate Induces ACSL4 Expression and Lactylation to Activate Ferroptosis during Intervertebral Disc Degeneration

Kaiqiang Sun, Yangyang Shi, Yan Chen, Shunmin Wang et autres

The abnormal activation of the inflammatory microenvironment is frequently accompanied by metabolic changes that affect the development of various diseases. However, the relationship between metabolic reprogramming and intervertebral disc degeneration (IVDD) remains unclear. This study aims to reveal the metabolic changes in …

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Targeting FABP4 to Inhibit AGEs ‐ RAGE / NF ‐ κB Signalling Effectively Ameliorates Nucleus Pulposus Dysfunction and Angiogenesis in Obesity‐Related Intervertebral Disc Degeneration

Lin Han, Fudong Li, Huiqiao Wu, Weiheng Wang et autres

Intervertebral disc degeneration (IVDD) is a primary contributor to low back pain, posing significant social and economic burdens. Increasing evidence shows that obesity contributes to IVDD, yet the underlying mechanisms remain elusive. Here, we firstly revealed a causal correlation between obesity and …

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Integrating Bulk RNA and Single‐Cell RNA Sequencing Identifies and Validates Lactylation‐Related Signatures for Intervertebral Disc Degeneration

Yangyang Shi, Fudong Li, Wenbo Lin, Linhui Han et autres

Glycolysis-related lactylation has gained wide attention for regulating various cellular functions and diseases. Nevertheless, its intricate involvement in intervertebral disc degeneration (IVDD) is not yet fully understood. In this study, we unrevealed the intricate association between elevated lactylation levels and the development …

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De novo protein design with a denoising diffusion network independent of pretrained structure prediction models

Yufeng Liu, Sheng Wang, Janet Dong, Ling-Hui Chen et autres

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Single‐cell RNA sequencing integrated with bulk RNA sequencing analysis reveals the protective effects of lactate‐mediated lactylation of microglia‐related proteins on spinal cord injury

Bin Zhang, Fudong Li, Yangyang Shi, Chenglong Ji et autres

Abstract Background and Objectives Spinal cord injury (SCI) results in significant neurological deficits, and microglia play the critical role in regulating the immune microenvironment and neurological recovery. Protein lactylation has been found to modulate the function of immune cells. Therefore, this study …

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Phase separation of hnRNPA1 and TERRA regulates telomeric stability

Ziyan Zoe Xu, Yongrui Liu, Fudong Li, Yi Yang et autres

Telomeres are the complexes composed of repetitive DNA sequences and associated proteins located at the end of chromatin. As a result of the DNA replication ending issue, telomeric DNA shortens during each cell cycle. The shelterin protein complex caps telomeric ends and …

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Modified Tracheal Traction Exercise Reduces the Incidence of Dysphagia in Patients with Multilevel Anterior Cervical Discectomy and Fusion

Jiasen Wei, Fudong Li, Jingchuan Sun, Zhen-jun Zhu et autres

OBJECTIVES: Dysphagia, an impairment in swallowing, is a frequent and debilitating complication for patients undergoing anterior cervical discectomy and fusion (ACDF), a common surgical treatment for degenerative cervical myelopathy (DCM). This retrospective study aimed to assess the efficacy of modified tracheal traction …

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