Wenwei Zhang

Abstract 4369312: NOX2 Knockdown Attenuates Atrial Fibrillation-Induced Senescence Marker Upregulation and Atrial Fibrillation Burden in Canine Atria

Cian O’Donnell, Asish K. Ghosh, Karim Ullah, Aleksei Mikhailov et autres

Background: Atrial fibrillation (AF) is associated with aging and increased expression of senescence-associated secretory phenotype (SASP) markers. It remains unclear whether AF directly exacerbates atrial aging and whether inhibition of oxidative pathways can reverse this effect. Hypothesis: We hypothesized that persistent AF …

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PO-05-015 REGION-SPECIFIC FREQUENCY DEPENDENT UPREGULATION OF SENESCENCE MARKERS IN THE LEFT ATRIUM IN A CHRONIC ATRIAL FIBRILLATION CANINE MODEL

Cian O’Donnell, Aleksei Mikhailov, Shin Yoo, Lauren Benson et autres

Abstract 17206: Targeted Ablation at Regions of High Oxidative Injury in Persistent Atrial Fibrillation in a Canine Model — A New Electrogram Based Therapeutic Strategy in Atrial Fibrillation?

Markus Rottmann, Anna Pfenniger, Shin Yoo, David A. Johnson et autres

Introduction: Oxidative stress (OS) plays an important role in the development of atrial fibrillation (AF). However, it is currently not possible to detect regions of high OS in the atria of individual AF patients. Hypothesis: We hypothesized that in persistent AF, electrograms …

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Results and Discussion on the Synthesis and Analysis of [Ni(Me3en)(acac)]BPh4 Complex: The Results and Discussion of Inorganic and Analytical Chemistry Experiment of the 10th National Undergraduate Chemistry Laboratory Tournament

Zhiqiang Dong, Xin Chen, Fengbin Wang, Qīng Wáng et autres

摘要： 介绍南京大学为第10届全国大学生化学实验邀请赛设计的无机及分析化学实验试题，即“配合物[Ni (Me3en)(acac)]BPh4的合成及其溶剂/热致变色行为研究”实验中有关合成及组成测定部分实验实施过程、结果及其拓展问题的探讨内容。以所展示的详细直观的合成实验流程为载体，围绕着合成两大目标“质”和“量”，即如何才能得到又“好”又“多”的[Ni (Me3en)(acac)]BPh4配合物的问题为导向，以设问、探讨的方式引导学生认识合成过程中实验条件的控制、实验现象的分析以及中间产物及杂质的分离、分析鉴定等对指导合成的意义，培养学生分析、判断、归纳、总结的能力以及批判性思维能力。

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Abstract 12592: Acute Administration of N-Acytylcysteine Leads to Highly Specific Sub-Regional Changes in AF Electrogram Characteristics - A New Way to ‘Uncover’ Regions of High Oxidative Injury in the Fibrillating Atrium?

Markus Rottmann, Anna Pfenniger, Shin Yoo, David A. Johnson et autres

Introduction: It is currently not possible to measure and therapeutically target oxidative injury (OI) in the intact fibrillating atrium. Hypothesis: We postulated that measurement of AF electrogram characteristics after acute administration of a reactive oxygen species (ROS) scavenger can help ‘uncover’ regions …

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Clinical evaluation of preoperative embolization, vertebroplasty, and decompression in the treatment of aggressive vertebral hemangiomas

Meng Kong, Kai Zhu, Xing Han, Wenwei Zhang et autres

Objective: To evaluate the efficacy and safety of preoperative embolization and vertebroplasty in the treatment of aggressive hemangioma. Methods: A retrospective clinical review of patients diagnosed with aggressive vertebral hemangiomas was conducted. All the patients were assigned to three groups according to …

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Cytokines in abdominal exudate and serum predict small bowel obstruction following appendectomy

Hui Ding, Hongbo Li, Hualong Yu, Wenwei Zhang et autres

BACKGROUND: This study aimed to investigate the value of inflammatory markers for the prediction of small bowel obstruction (SBO) following appendectomy. METHODS: We included cases of acute appendicitis that underwent laparoscopic appendectomy (LA) in the Qingdao Municipal Hospital between January 2017 and …

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Attenuation of Oxidative Injury With Targeted Expression of NADPH Oxidase 2 Short Hairpin RNA Prevents Onset and Maintenance of Electrical Remodeling in the Canine Atrium

Shin Yoo, Anna Pfenniger, Jacob A Hoffman, Wenwei Zhang et autres

Background: Atrial fibrillation (AF) is the most common heart rhythm disorder in adults and a major cause of stroke. Unfortunately, current treatments of AF are suboptimal because they are not targeted to the molecular mechanisms underlying AF. Using a highly novel gene …

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BGISEQ-500 （DNBSEQ-G50） Sequencing v1

Jie Huang, Xinming Liang, Yuankai Xuan, Chunyu Geng et autres

BGISEQ-500 is a new desktop sequencer developed by BGI. Using DNA nanoball and combinational probe anchor synthesis developed from Complete Genomics™ sequencing technologies, it generates short reads at a large scale.

The relevant research of thyroid hormones and clinical features in treatment-resistant depression

Yan Yu, Qifeng Du, Jianlong Zhang, Jing Hu et autres

Objective To explore the clinical characteristics of treatment-resistant depression (TRD) and of its relevance with thyroid hormones. Methods 43 patients with TRD and 48 patients with non-TRD were assessed with 17-item Hamilton depression scale (HAMD-17) and Hamilton anxiety scale (HAMA). The serum …

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A Population of Human Mesenchymal Stem Cells Specific to the Fetal Liver Development

Wenwei Zhang

Material and Methods Fetal liver specimensHuman fetal livers at GW 11 or 12 were collected and carefully dissected from fetuses after voluntary pregnancy termination with the mothers consent, abiding by the ethical French guidelines.

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[Cerebral microbleeds detected on T2-weighted gradient echo magnetic resonance and its clinical significance].

Tiemin Wei, Limin Zhou, Jiansong Ji, Wenwei Zhang

OBJECTIVE: To explore the diagnostic value of T2-weighted gradient-echo magnetic resonance imaging (MRI) in cerebral microbleeds (CMBs) and its clinical significance. METHODS: The distribution of CMBs and follow-up observations were performed by routine T1WI, T2WI and T2-weighted gradient echo sequence in 634 …

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