Mingyue Liu

Phenolics in sesame meal protein: Structural characterization, interaction mechanism, and impacts on protein functional properties

Jing-Chan Zhao, Mingyue Liu, Jia-Xuan Bai, Bei-Bei Guo et autres

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Feasibility analysis of pharmacy practice based on the evidence-based pharmacy model in the treatment of patients with severe pneumonia

Mingyue Liu, Jiayun Liu, Ying Chao Ji, Long‐Sheng Lu

Objective: To investigate the application of pharmacy practice based on the evidence‐based pharmacy (EBP) model in the anti‐infective treatment of patients with severe pneumonia. Methodology: This was a retrospective study. A total of 200 patients diagnosed with severe pneumonia caused by multidrug‐resistant …

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Value of elevated 1-hour post-load plasma glucose level in identifying risk of MAFLD in non-diabetic obese children and adolescents

Xiaoxiao Liu, Zesheng Peng, Shifeng Ma, Fei Liu et autres

OBJECTIVE: To evaluate the potential value of 1-h post-load plasma glucose level in patients who are prone to suffer from metabolic associated fatty liver disease (MAFLD) in a group of non-diabetic obese children and adolescents. METHODS: Cardio-metabolic risk factors, oral glucose tolerance …

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The longitudinal bidirectional association between cardiovascular disease and depressive symptoms among middle-aged and elderly adults: evidence from a nationwide cohort study in China

Jie He, Mingyue Liu, Ziying Zhang, Mingzhu Fang et autres

Background Although cardiovascular disease (CVD) and depressive symptoms frequently co-occur, their temporal directional relationship remains poorly understood. This study aimed to investigate the bidirectional association between depression and CVD in middle-aged and elderly Chinese adults through longitudinal analyses. Method This longitudinal cohort …

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The Active Ingredients and Mechanisms of Xuefuzhuyu Pills in Treating Hyperprolactinemia Caused by Antipsychotics based on UHPLCQ-TOF-MS/MS, Network Pharmacology, and Molecular Docking Validation

Linliu Du, Zihuan Zhang, Mingyue Liu, Xiufang Zhu et autres

BACKGROUND: XueFuZhuYu pills (XFZY), a traditional Chinese herbal formula originated from the xuefuzhuyu decoction in Correction on Errors in Medical Classics, has a certain clinical effect on the treatment of hyperprolactinemia (HPRL) caused by antipsychotics. However, the active ingredients and mechanism by …

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High-Accurate Third-Generation Sequencing to Comprehensively Decipher BCR::ABL1 TKIs in-Cis Resistant Mutations

Jiaqi Chen, Qi-Hui Chen, Huanhuan Hu, Fang Wang et autres

Background Drug-resistant mutations in the ABL1 kinase domain (KD) of BCR::ABL1 are primary mechanisms of resistance to tyrosine kinase inhibitor (TKI) therapy in Ph-positive leukemia. These mutations alter the conformation of ABL1 within BCR::ABL1, impairing TKI and thus diminishing their anti-leukemia efficacy. …

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Effects of Different LED Spectra on the Antioxidant Capacity and Nitrogen Metabolism of Chinese Cabbage (Brassica rapa L. ssp. Pekinensis)

Yubing Liu, Junwei Wang, Mingyue Liu, Yanling Li et autres

Light quality optimization is a cost-effective method for increasing leafy vegetable quality in plant factories. Light-emitting diodes (LEDs) that enable the precise modulation of light quality were used in this study to examine the effects of red-blue (RB), red-blue-green (RBG), red-blue-purple (RBP), …

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Targeting m6A mRNA demethylase FTO alleviates manganese-induced cognitive memory deficits in mice

Yi Feng Wen, Zhushan Fu, Jiashuo Li, Mingyue Liu et autres

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Effects of OSA-starch-fatty acid interactions on the structural, digestibility and release characteristics of high amylose corn starch

Mingyue Liu, Xiaoyan Wang, Yihui Li, Danni Jin et autres

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Clinical application of machine learning‐based pathomics signature of gastric atrophy

Yadi Lan, Bing Han, Tianyu Zhai, Qianqian Xu et autres

Background: The diagnosis of gastric atrophy is highly subjective, and we aimed to establish a model of gastric atrophy based on pathological features to improve diagnostic consistency. Methods: We retrospectively collected the HE-stained pathological slides of gastric biopsies and used CellProfiler software …

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Decoding selectivity: computational insights into AKR1B1 and AKR1B10 inhibition

Mingyue Liu, Xiaochun Qin, Jing Li, Yuting Jiang et autres

Understanding selectivity mechanisms of inhibitors towards highly homologous proteins is of paramount importance in the design of selective candidates. Human aldo-keto reductases (AKRs) pertain to a superfamily of monomeric oxidoreductases, which serve as NADPH-dependent cytosolic enzymes to catalyze the reduction of carbonyl …

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Dickkopf-related protein 1 as a biomarker of local immune status and worse prognosis of Oral squamous cell carcinoma

Dongxu Liu, Kehan Wu, Xi-Yan ZANG, Jiayi Lu et autres

BACKGROUND: Oral squamous cell carcinoma (OSCC) is an infiltrative malignancy characterized by a significantly elevated recurrence rate. Dickkopf-related protein 1 (DKK1), which plays an oncogene role in many cancers, acts as an inhibitor of the Wingless protein (Wnt) signaling pathway. Currently, there …