Yao Sun

First report of donor-derived active multiple myeloma from one AML patient after allogeneic stem cell transplantation

Na Liu, Yao Sun, Yingjie Liu, Liangding Hu

To the editorWith improvements in hematopoietic stem cell transplantation (HSCT) strategies, the overall survival of patients with hematological malignancies has significantly improved. However, th...

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Exploring the mediating role of potential therapeutic genes in the pathogenesis of hypopituitarism through the metabolites from a genomic perspective

Yao Sun, Ying Zhang, Tengfei Luan, Ruichun Li et autres

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Ceftriaxone attenuates Poly I:C–induced neuroinflammation in vitro by modulating glutamate transport, synaptic integrity, and immunometabolic reprogramming

Xinyuan Shi, Yao Sun, Shirin Hosseini, Fangfang Chen et autres

Introduction: Neuroinflammation triggered by viral infections is increasingly recognized as a driving force in neurodegenerative disease, promoting chronic neuronal injury and cognitive decline. A central mechanism in this process is impaired glutamate clearance due to downregulation of the astrocytic glutamate transporter GLT-1 …

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Role of erythritol in coronary heart disease, ischemic stroke, and venous thromboembolism: A Mendelian randomization analysis

Yao Sun, Jinqiao Wu, Ze Peng, Juan Jin

Erythritol, a widely used nonnutritive sweetener, has been linked to increased cardiovascular risk in observational studies. However, whether erythritol causally contributes to arterial and venous thrombotic diseases remains unclear. We performed a 2-sample Mendelian randomization (MR) study using 60 independent single nucleotide …

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Correction: Targeting and cytotoxicity of chimeric antigen receptor T cells grafted with PD1 extramembrane domain

Ang Zhang, Shenyu Wang, Yao Sun, Yikun Zhang et autres

In this article [1], Fig. 5B appeared incorrectly and have now been corrected in the original publication.Image Duplication in Fig. 5B (Mock-T Group on Day 21): There is a duplication of images between the third and fourth mouse.Upon review, we identified that …

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Deciphering genetic causality between plasma BDNF and 91 circulating inflammatory proteins through bidirectional mendelian randomization

Yao Sun, Xinyuan Shi, Melanie Ohm, Martin Körte et autres

Prior studies reported an association between the levels of brain-derived neurotrophic factor (BDNF) circulating in the bloodstream and those of different inflammatory factors. However, their causal relationship remains unclear. Here, we performed a Mendelian randomization (MR) study to investigate the causal relationships …

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Isolated CNS B lymphoid/myeloid bilineage relapse following allogeneic hematopoietic stem cell transplantation in adult acute myeloid leukemia with KMT2A::MLLT1 rearrangement

Yao Sun, Na Liu, Yingjie Liu, Jing Deng et autres

To the editorThe lysine methyltransferase 2 A (KMT2A) gene, formerly known as the mixed-lineage leukemia (MLL) gene, is notable for its propensity to undergo rearrangement with over 130 distinct pa...

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Chinese expert consensus on clinical management of hepatopathy-related thrombocytopenia (2023 edition)

Hang Yu, Hongli Yu, Yao Sun, Fu‐Sheng Wang et autres

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Ceftriaxone Attenuates Poly I:C–Induced Neuroinflammation in vitro by Modulating Glutamate Transport, Synaptic Integrity, and Immunometabolic Reprogramming

Xinyuan Shi, Yao Sun, Shirin Hosseini, Fangfang Chen et autres

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Enhanced Tumor Control and Hearing Loss Prevention Achieved with Combined Immune Checkpoint Inhibitor and Anti-VEGF Therapy in Vestibular Schwannoma Model

Simeng Lu, Zhenzhen Yin, Limeng Wu, Yao Sun et autres

Abstract Background NF2 -related schwannomatosis ( NF2 -SWN) is a debilitating condition that calls for robust treatment options. The defining feature of NF2 -SWN is the presence of bilateral vestibular schwannomas (VSs), which grow over time and can result in irreversible sensorineural …

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Losartan rewires the tumor-immune microenvironment and suppresses IGF-1 to overcome resistance to chemo-immunotherapy in ovarian cancer

Yao Sun, Zhenzhen Yin, Shuang Li, Limeng Wu et autres

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Targeting and cytotoxicity of chimeric antigen receptor T cells grafted with PD1 extramembrane domain

Ang Zhang, Shenyu Wang, Yao Sun, Yikun Zhang et autres

BACKGROUND: Immunosuppression induced by programmed cell death protein 1 (PD1) presents a significant constraint on the effectiveness of chimeric antigen receptor (CAR)-T therapy. The potential of combining PD1/PDL1 (Programmed cell death 1 ligand 1) axis blockade with CAR-T cell therapy is promising. …

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