Ying Zhang

Tumor-suppressive tRNA-derived RNA fragment itRF-GlnCTG targets the RBMX-m6A axis to destabilize RCN1 mRNA in esophageal squamous cell carcinoma

Ying Zhang, Weiqing Lu, Lan Hu, Zikun Huang et autres

Transfer RNA-derived small RNAs (tsRNAs) have been recognized as important regulators in human cancers. However, the role of tumor-suppressive tsRNAs in esophageal squamous cell carcinoma (ESCC) has not been thoroughly characterized. This study sought to elucidate the function of tsRNA-Gln-i-0061 (itRF-GlnCTG) in …

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SNORA11B recruits SWI/SNF to suppress esophageal squamous cell carcinoma malignancy by promoting GPD1-mediated G3P accumulation and mitochondrial damage

Lan Hu, Weiqing Lu, Zikun Huang, Dongchen Liu et autres

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CPSF2-mediated 3’ UTR truncation of MTERF3 drives mitochondrial dysfunction and osteosarcoma progression

Ying Zhang, Weiqing Lu, Zikun Huang, Lan Hu et autres

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Exploring the mediating role of potential therapeutic genes in the pathogenesis of hypopituitarism through the metabolites from a genomic perspective

Yao Sun, Ying Zhang, Tengfei Luan, Ruichun Li et autres

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OA16.03 Sequencing of Radiotherapy and Immunotherapy Stratifies Pneumonitis Risk: A Propensity-Matched Multicenter Study

Wei Wei, Yanyun Ruan, Ying Zhang, Zhonghou Rong et autres

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Enhanced Survival in Stage IV NSCLC Patients: A Comparison of Sequential vs. Concurrent Radiotherapy Combined with Immunotherapy

Y. Wang, J. Wang, Ying Zhang, Jinguo Liu et autres

Alternative cleavage and polyadenylation: key regulatory mechanisms in health and disease

Ying Zhang, Zikun Huang, Weiqing Lu, Zhaoyong Liu

Alternative polyadenylation (APA) is a critical post-transcriptional regulatory mechanism that generates diverse mRNA isoforms by selecting different polyadenylation sites within pre-mRNAs, thereby modulating the length of the 3' untranslated region (3' UTR), thereby fine-tuning gene expression and protein synthesis. APA regulation involves …

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Angiogenesis and immune microenvironment in triple-negative breast cancer: Targeted therapy

Ying Zhang, Hao Yang, Yanhong Jiang, Yijing Jiang et autres

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FOXO1 mediates miR-99a-5p/E2F7 to restrain breast cancer cell proliferation and induce apoptosis

Ying Zhang, Haili Wang, Yiliang Wang, Bo Ma

BACKGROUND: FOXO1 is known to act as a tumor suppressor gene in breast cancer, but its exact mechanism of action remains unclear. OBJECTIVE: This study aimed to clarify how FOXO1 suppresses breast cancer cell proliferation and induces apoptosis. METHODS: Breast cancer cell …

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Alternative polyadenylation in cancer: Molecular mechanisms and clinical application

Ying Zhang, Zikun Huang, Weiqing Lu, Zhaoyong Liu

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EP.13A.04 A Study of Surufatinib Combined with Low Dose Topotecan in Second or Third-Line Multiple Distant Organ Metastatic ES-SCLC

Hesheng Qian, Lin Zhang, S. Wang, Juan Wang et autres

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CPSF3 regulates alternative polyadenylation of CNIH2 to promote esophageal squamous cell carcinoma progression

Ying Zhang, Dongchen Liu, Dan Guo, Wenting Lin et autres

Alternative polyadenylation (APA), an important post-transcriptional regulatory mechanism, is aberrantly activated in cancer，but how APA functions in tumorigenesis remains elusive. We analyzed APA events in RNA-seq data in TCGA and reported 3'UTR alterations associated with esophageal squamous cell carcinoma (ESCC) patient prognosis …

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