Juan Jin

Baseline characteristics of people living with HIV with different CD4(+) T cell depletion

Dingsheng Kong, Juan Jin, Peipei Luo

HIV-1 infection can easily cause CD4(+) T cell depletion. To investigate the impact of CD4(+) T cell depletion on the health of people living with HIV-1 (PLWH), we collected and analyzed baseline data from 5139 volunteers who had never received any treatment. …

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Role of erythritol in coronary heart disease, ischemic stroke, and venous thromboembolism: A Mendelian randomization analysis

Yao Sun, Jinqiao Wu, Ze Peng, Juan Jin

Erythritol, a widely used nonnutritive sweetener, has been linked to increased cardiovascular risk in observational studies. However, whether erythritol causally contributes to arterial and venous thrombotic diseases remains unclear. We performed a 2-sample Mendelian randomization (MR) study using 60 independent single nucleotide …

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Pharmacokinetics, Bioequivalence, and Safety of Levothyroxine Sodium Tablets in Healthy Chinese Subjects

Juan Jin, Chunrong Huang, Fangliang Gan, Tuo Li et autres

Recently, a local pharmaceutical company produced levothyroxine sodium tablets, an endogenous drug that helps improve water-salt metabolism and reduce myxedema. However, the bioequivalence of these tablets is not well known. The present study aimed to investigate the bioequivalence, pharmacokinetics, and safety of …

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Prevalence, Risk Factors, and Clinical Outcomes with Advanced HIV Disease Among People with Newly Diagnosed HIV During the “Treat-All” Era: A Retrospective Cohort Study From Xi’an City, China

Juan Jin, Jie Chen, Jinling Yin, Huanhuan Ba et autres

Purpose: China launched “treat-all” in 2016 to make all HIV-positive people eligible for ART regardless of disease stage. Widespread treatment may not eliminate advanced HIV. This study investigated the prevalence, characteristics, risk factors, and clinical outcomes of advanced HIV disease (AHD) in …

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A comparative study based on ainuovirine/lamivudine/tenofovir against HIV-1

Peipei Luo, Juan Jin, Jiajia Li, Jinling Yin et autres

BACKGROUND: Ainuovirine, as a third-generation non-nucleoside reverse transcriptase inhibitor against HIV-1, is widely used in China. To evaluate its therapeutic efficacy and disadvantages, a comparative study based on Ainuovirine had been conducted. METHOD: We investigated 199 people living with HIV-1 who received …

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Effectiveness and safety of dolutegravir plus lamivudine in treating HIV in China, including outcomes of patients coinfected with tuberculosis

Haohua Hou, Huanhuan Ba, Xinyan Jin, Peipei Luo et autres

Antiretroviral regimens for human immunodeficiency virus (HIV) infection have continuously evolved; however, antiretrovirals can cause severe adverse reactions. Two-drug regimen therapy can decrease lifetime cumulative drug exposure and long-term toxicities associated with multiple antiretrovirals. The preferred 2-drug regimen constitutes dolutegravir (DTG) and …

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Artificial intelligence applied in cardiovascular disease: a bibliometric and visual analysis

Jirong Zhang, Jimei Zhang, Juan Jin, Xicheng Jiang et autres

Background With the rapid development of technology, artificial intelligence (AI) has been widely used in the diagnosis and prognosis prediction of a variety of diseases, including cardiovascular disease. Facts have proved that AI has broad application prospects in rapid and accurate diagnosis. …

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Pharmacokinetics, Bioequivalence, and Safety of Esomeprazole Magnesium Enteric‐Coated Capsules in Healthy Chinese Subjects

Juan Jin, Changhai Zhu, Wanni Feng, Ang He et autres

This bioequivalence study is critically important for drug production. Recently, a local pharmaceutical company produced esomeprazole magnesium enteric-coated capsules, a major drug to help to eradicate Helicobacter pylori, but the bioequivalence is not well known. The present study aimed to evaluate the …

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Patient-Reported Noninfectious Comorbidities in Chinese HIV-Infected Patients: The Gaps Among Self-Awareness, Diagnosis, and Prevalence

Jun Chen, Hongzhou Lu, Shuiqing Liu, Jun Liang Liu et autres

Abstract Background: This study was performed to investigate the gaps among patient-reported data, physician-reported data, and laboratory test data in human immunodeficiency virus (HIV)-infected patients and to detect potential risk factors for the awareness gap. Methods: We included patients from 38 hospitals …

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Application of Food Simulation Model in Diet Education for Diabetes Patients

Juan Jin

Objective To explore the effect of application of the food simulation model for diet education in diabetes patients.Methods A total of 206 diabetes patients were randomly divided into experimental group given food simulation model as the pattern of diet education and control …

Hepatic and intestinal first-pass effects of rabeprazole in rabbits

Juan Jin

Aim To investigate the pharmacokinetics of rabeprazole after intravenous,intraportal and intraduodenal administration at various doses and to clarify the impact of hepatic and intestinal first-pass effects to bioavailability of rabbits.Methods By developing an in vivo intestinal and vascular access-ported(IVAP) rabbit model,doses of …