Bo Jiao

Palmitoyltransferase ZDHHC19 regulates histone-to-protamine exchange during spermiogenesis in mice

Jiaoyang Li, Zhizhou Xia, Bo Jiao, Zhitong Li et autres

Spermiogenesis, the final phrase of spermatogenesis, involves replacing histones by protamines, a process known as histone-to-protamine exchange, which is crucial for chromatin condensation. While this exchange is essential, the precise mechanisms remain incompletely understood. In this study, we discovered that the palmitoyltransferase …

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Proteomic subtypes enrich current acute myeloid leukemia nomenclature and reflect intrinsic pathogenesis alongside aging

Wenyan Cheng, Xiao Yi, Zhenyi Wang, Jianfeng Li et autres

ABSTRACT: Acute myeloid leukemia (AML) is a highly heterogeneous hematological malignancy that increasingly affects the older population, with its posttranscriptional landscape remaining largely elusive. Establishing a stable proteomics-based classification system and systematically screening age-related proteins and regulatory networks are crucial for understanding …

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Loss of DCAF8 impairs hematopoietic stem cell function with cellular senescence via the DOCK11-CDC42 axis

Pengfei Xu, Xiuli Zhang, Donghe Li, Bo Jiao et autres

ABSTRACT: Hematopoietic stem cells (HSCs) are responsible for sustaining the hematopoietic system throughout life, and their functional decline contributes to hematological disorders and organismal aging. Understanding the molecular mechanisms that govern HSC function is critical for developing interventions for treating and preventing …

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Transposable elements as novel therapeutic targets for PARPi-induced synthetic lethality in PcG-mutated blood cancer

Bernd B. Zeisig, Chiou‐Tsun Tsai, Clémence Virely, Tsz Kan Fung et autres

ABSTRACT: Loss-of-function (LoF) mutations frequently found in human cancers are generally intractable by classical small molecule inhibitor approaches. Among them are mutations affecting Polycomb-group (PcG) epigenetic regulators, enhancer of zeste homolog 2 (EZH2) and Additional sex combs like 1 (ASXL1), frequently found …

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Abstract 4319: Loss of Golga7 suppresses oncogenic Nras-driven leukemogenesis without detectable toxicity in adult mice

Bo Jiao, Lei Yan, Rui Zhang, Wei Hong Huang et autres

Abstract NRAS mutations are prevalent in human hematological malignancies and are also common in certain solid tumors, including melanoma and colon cancer. Despite their crucial role in oncogenesis, no effective therapies targeting NRAS have been developed. Inhibiting NRAS localization to the plasma …

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H2-induced Pt segregation constructs the Pt@PtNi@Pt nanowires for promoted hydrogen evolution

Cuihua An, Chao Wang, Xiaoran Han, Bo Jiao et autres

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Clinical Significance of JAM ‐2 Expression in the Vaginal Wall Tissues of Patients With Pelvic Organ Prolapse

Yuan Liu, Yuelin Wu, Sheng Biao Wan, Shengyi Gu et autres

This study aimed to elucidate the roles of junctional adhesion molecule 2 (JAM-2), collagen I and matrix metalloproteinase 2 (MMP-2) in the pathogenesis of pelvic organ prolapse (POP) and explore their potential as diagnostic markers. We examined 82 POP patients and 64 …

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Loss of Golga7 Suppresses Oncogenic Nras ‐Driven Leukemogenesis without Detectable Toxicity in Adult Mice

Bo Jiao, Lei Yan, Rui Zhang, Wei Hong Huang et autres

Abstract NRAS mutations are prevalent in human hematological malignancies and are also common in certain solid tumors, including melanoma and colon cancer. Despite their crucial role in oncogenesis, no effective therapies targeting NRAS have been developed. Inhibiting NRAS localization to the plasma …

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Metabolomic insights into pathogenesis and therapeutic potential in adult acute lymphoblastic leukemia

Tuantuan Gui, Bo Jiao, Xuan Liu, Xiaolin Ma et autres

Acute lymphoblastic leukemia (ALL) poses challenges in adult patients, considering its heterogeneous nature and often suboptimal treatment outcomes. Here, we performed a study on 201 newly diagnosed adult ALL cases (age ≥ 15 y) to generate intracellular and dynamic serum metabolomic profiles. …

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Protective Effect of Resveratrol Against Peri-Implant Inflammation and Oxidative Stress: An in vivo Study

Chao Zhang, Bo Jiao, Dajun Qian

Background: Implants are commonly used to repair teeth. However, with their widespread use, the incidence of peri-implantitis has also increased. The Mitogen activated protein kinase/Protein kinase B/Nuclear factor kappa-B (MAPK/AKT/NF-κB) signaling pathway is associated with various inflammatory responses. This study aims to …

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Suppression of microtubule acetylation mediates the anti-leukemic effect of CDK9 inhibition

Xi Xie, Baoyuan Zhang, Donghe Li, Jiaming Gao et autres

Cyclin-dependent kinase 9 (CDK9) is a crucial component of transcription and potential target for anti-cancer therapies, particularly for hematological malignancies. However, the precise mechanisms underlying the therapeutic effects of CDK9 inhibitors remain not fully understood. Here, we found that inhibiting CDK9 either …

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The Endocannabinoid N-Arachidonoyl Dopamine Induces Leukemia Cell Pyroptosis to Overcome the Venetoclax Resistance

Min Huan Wu, Lingyun Tang, Bo Jiao, Ping Liu et autres

Bcl-2 inhibitor has largely changed the treatment options in elderly acute myeloid leukemia patients, while drug insensitivity and resistance still hinder the overall survival. In our previous study, a natural product, N-arachidonoyl dopamine (NADA), was discovered to inhibit NRAS membrane translocation and …

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