Ranran Wang

Impaired Glycolysis Leads to Defective Efferocytosis and Impaired Plaque Resolution in Tet2 Clonal Hematopoiesis

Mustafa Yalçınkaya, Cheng-Chieh Hsu, Linke Li, Ranran Wang et autres

BACKGROUND: Clonal hematopoiesis (CH) arising from mutations in hematopoietic genes has been identified as an important risk factor for atherosclerotic cardiovascular disease. Despite the established role of some CH mutations in promoting atherosclerosis progression, their role in clinically relevant LDL (low-density lipoprotein) …

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Nonlinear Granger causality and LSTM-Transformer hybrid forecasting reveal meteorological drivers of influenza incidence in Gansu Province

Yalin Jiao, Jingyi Xin, Chengqiao Song, Bangze Fu et autres

Influenza poses a significant public health burden with distinct seasonality. In regions with pronounced climatic features like Gansu Province, China, traditional statistical models often fail to capture the nonlinear and lagged effects of meteorological drivers on influenza transmission. A deeper understanding of …

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Mycobacterium tuberculosis IDH-PPARγ interaction suppresses GPX4 to drive macrophage ferroptosis and sustain persistent infection

Wenyuan Pu, Ximeng Zhang, Man Tian, Zhiyi He et autres

Mycobacterium tuberculosis (M.tb) actively reprograms host lipid metabolism during infection; however, the underlying mechanism remains poorly understood. How M.tb manipulates macrophage lipid metabolism to induce lipid peroxidation and ferroptosis for bacterial persistence remains a fundamental question. Here, using single-cell RNA sequencing and …

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Targeted dermal delivery of phloretin via thermoresponsive nanoparticles potently suppresses STAT3/NF-κB-driven psoriatic inflammation

Renwei Lu, Ruyi Zhao, Panpan Lian, Gang Chen et autres

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Abstract Thu057: Ninjurin-1 Deficiency Drives Atherosclerosis Progression in Clonal Hematopoiesis

Cheng-Chieh Hsu, Wenli Liu, Brian Hardaway, Ranran Wang et autres

Inflammasome activation (IA) has been identified as a potential therapeutic target in atherosclerotic cardiovascular disease (CVD). Clonal hematopoiesis (CH), involving somatic mutations in genes driving hematopoiesis, has emerged as an independent CVD risk factor. JAK2V617F (JAK2VF) is a CH variant that is …

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Glycyrrhiza Uralensis Fisch. Alleviates Paraquat‐Induced Lung Injury by Repairing Mitochondrial Respiratory Chain Dysfunction

Shi Dong, Ranran Wang, Shuhui Zhang, Yuxian Ma et autres

Paraquat (PQ) causes acute lung injury in part via mitochondrial respiratory dysfunction. We evaluated whether Glycyrrhiza uralensis. extract (LE) confers holistic protection and whether liquiritin (LQ) is a key mitochondria-targeting constituent. A PQ lung-injury model was established in KM mice by a …

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Clinical and Economic Burden of Cytomegalovirus (CMV) Infection/Disease Among Hospitalized Adult Allogeneic Hematopoietic Stem Cell Transplant (Allo‐HSCT) Recipients in China

Chen-Hua Yan, Linghui Xia, Xuan Lu, Yu Wang et autres

Cytomegalovirus (CMV) infection is a prevalent complication among allogeneic hematopoietic stem cell transplant (allo-HSCT) recipients, posing significantly impact on clinical outcomes and healthcare costs. This study aims to assess the clinical and economic burden of CMV infection in hospitalized adult allo-HSCT recipients …

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Isorhamnetin attenuates lipopolysaccharide-induced myocardial inflammatory injury by inhibiting PPARγ and preserving mitochondrial homeostasis

Zhongchao Gai, Ranran Wang, Linlin Xiao, Sijia Yan et autres

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Serum proteomics and machine learning identify PSMD11 as a prognostic biomarker in severe fever with thrombocytopenia syndrome

Chenxi Zhao, Ziruo Ge, Ranran Wang, Yanli Xu et autres

Background Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne viral disease associated with high mortality. This study aimed to characterize serum proteomic signatures linked to adverse outcomes and to identify prognostic biomarkers with potential translational value for patient management. Methods …

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Rare TRAF5 coding variants in systemic lupus erythematosus patients aggravate pulmonary hypertension via endothelial dysfunction

Xiaoyue Deng, Tianyi Yuan, Junyan Qian, Qian Wang et autres

loss-of-function exacerbates SLE-PAH by inducing EC dysfunction via the BMP/TGF-β signaling, suggesting potential therapeutic targets.

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Lactate Dehydrogenase-to-Lymphocyte Ratio Predicts Early Mortality in Patients with Severe Fever with Thrombocytopenia Syndrome

Ruize Ma, Jingxia Wang, Ranran Wang, Ruihua Zhang et autres

Abstract Background Severe fever with thrombocytopenia syndrome (SFTS) is caused by SFTS virus (SFTSV) with high mortality. Methods Between January 2022 and October 2024, a total of 208 cases from Yantai Qishan Hospital have been included in this study. The sLLR was …

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Mengding Yellow Bud Polyphenols Protect Against CCl 4 ‐induced Hepatotoxicity in Mice Via Inhibiting Oxidative Stress and Inflammation

Ranran Wang, Fei She, Ruokun Yi, Tiantian Hu et autres

ABSTRACT Mengding yellow bud polyphenols (MYBPs), as a plant active ingredient that may protect the liver, have not yet been elucidated for the potential molecular mechanism in preventing carbon tetrachloride (CCl 4 ) induced acute liver injury (ALI) in mice. The MYBPs …

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