State Key Laboratory of Analytical Chemistry for Life Science

Comparative genomic characterization and antimicrobial resistance of bacteremia-causing Enterococcus faecium and Enterococcus faecalis in a Chinese hospital

Ning Sun, Yong Chen, Xin Wu, Deyu Gao et autres

ABSTRACT Enterococci are common commensals of the human gut and important opportunistic pathogens, with Enterococcus faecium and Enterococcus faecalis being the most clinically prevalent species. A significant epidemiological shift has emerged with an increasing clinical burden of E. faecium . To compare …

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An efficient peroxymonosulfate activation by Nb2CTx-MXene mediated with CQDs composite catalyst for carbamazepine degradation: Kinetics and mechanistic insights

Muhammad Adnan, Zhenhua Zhao, Liling Xia, Ghulam Abbas Ashraf et autres

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An antibody-PROTAC conjugate targets BRD4/c-Myc/PD-L1 to enhance immunotherapy efficacy in triple-negative breast cancer

Yunru Gu, Chen Li, Yuhan Zhao, Tianrui Xu et autres

Triple-negative breast cancer (TNBC) remains an aggressive malignancy lacking effective and safe treatments. Proteolysis-targeting chimeras (PROTACs) represent a promising modality for intractable diseases, but their application in TNBC is hindered by inefficient delivery. Here, we develop ASA, a TNBC-targeting antibody-PROTAC conjugate that …

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A ROS-Responsive DNA Nanodevice for Targeted Cytosolic siRNA Delivery in Metabolic Dysfunction-Associated Steatohepatitis

Qi Wang, B Zhang, Yuang Wang, X X Xu et autres

Metabolic dysfunction-associated steatohepatitis (MASH) arises from an intricate interplay of dysregulated metabolic, inflammatory, and fibrogenic pathways, necessitating coordinated therapeutic intervention that remains inadequately achieved by current treatments. Small interfering RNA (siRNA) therapeutics offer a promising solution to this unmet need, but their …

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VDR-Spermidine Axis Protects Against Age-Related Granulosa Cell Dysfunction and Follicular Decline via DNMTs-Mediated p53 Methylation

Haiyun Chen, Qinghe Geng, Qiuyi Wang, Yuanqin Li et autres

). This led to SPD depletion, which in turn inhibited DNA methyltransferase (DNMTs) activity, resulting in hypomethylation of the p53 promoter and activation of the p53/p21 pathway. Crucially, supplementation with either SPD or its upstream methyl donor S-adenosylmethionine (SAM) rescued cVKO and …

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Targeted dermal delivery of phloretin via thermoresponsive nanoparticles potently suppresses STAT3/NF-κB-driven psoriatic inflammation

Renwei Lu, Ruyi Zhao, Panpan Lian, Gang Chen et autres

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Puerarin and DHEA combination therapy alleviates primary dysmenorrhea via inhibition of the Hsp90ab1/p38/JNK pathway

Zhengquan Zhu, JianGuo Ruan, Ruizhe Wang, Yihan Wang et autres

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Renal clearable exceedingly small amorphous iron oxide nanoclusters for high-resolution T1 magnetic resonance

Manman Xie, Yusong Peng, Cong Zhang, Jiahui Xu et autres

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Enzymatic Cascade-Powered Urinary Diagnostics for Visual Cancer Monitoring

Linlin Wang, Ruiyue Chen, Zhiyong Liu, Dongtao Zhou et autres

Accurate, real-time, noninvasive longitudinal diagnostic tools are essential for guiding personalized cancer therapy, and urine-based platforms represent a promising noninvasive avenue for continuous therapeutic monitoring. However, conventional approaches relying on passive detection of tumor-derived biomarkers shed into urine are often limited by …

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Semaglutide alleviates ovarian ferroptosis in polycystic ovary syndrome and is associated with reduced GPX4 promoter hypermethylation

Yi Zhang, Daojuan Wang, Xiaosa Si, Tingyu Wang et autres

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Corrigendum to “Nuclear receptor coactivator 4 linked to follicular dysplasia in polycystic ovary syndrome: A key regulator that aggravates ovarian granulosa cells ferritinophagy and ferroptosis” [Biochim Biophys Acta Mol Basis Dis. 1871 (7) (Oct 2025) 167955 (BBADIS 167955)]

Dejian Chen, Yu Wang, Xiaomin Wang, Xiaosa Si et autres

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Phase-Separation Engineered Nanomotors Enable Spleen-Tumor Dual Targeting to Reverse T-Cell Exhaustion

Zhiyong Liu, Xueting Shen, Qianglan Lu, Shurong Qin et autres

Prolonged antigen stimulation often induces CD8+ T-cell exhaustion, which undermines the efficacy of immunotherapy. To address this challenge, we developed Janus nanomotors (PML@fmPt NMs) constructed through cell membrane phase separation, providing an effective strategy for dynamic immunomodulation. In contrast to conventional nanoparticle …

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